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Autor:
Pieter Steenhuis, Thi Dinh La, Zhanna Gurenko, Hsin Ya Yang, Roslyn Rivkah Isseroff, Aaron M. Glucksman
Publikováno v:
PLoS ONE
PloS one, vol 16, iss 7
PLoS ONE, Vol 16, Iss 7, p e0253139 (2021)
PloS one, vol 16, iss 7
PLoS ONE, Vol 16, Iss 7, p e0253139 (2021)
Keratinocyte migration into skin wounds is the step of the healing process that correlates with the wound closure rate. Keratinocyte migration, and wound epithelialization are decreased when beta 2-adrenergic receptors (B2AR) are activated by 1 μM e
Autor:
J. P. Jones, William Parker, Caroline J. Smith, Zacharoula Konsoula, John Poulton, Jasmine Cendejas Hernandez, Navneet Suda
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0253543 (2021)
PLoS ONE, Vol 16, Iss 6, p e0253543 (2021)
Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders. We had previously postulated that acetaminophen exposure early in life, if combined with
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0247714 (2021)
PLoS ONE, Vol 16, Iss 4, p e0247714 (2021)
Optimal vancomycin exposure is important to minimize treatment failure of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. We aimed to analyze the impact of initial vancomycin pharmacokinetic/pharmacodynamic (PK/PD) parameters, includin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0249344 (2021)
PLoS ONE, Vol 16, Iss 4, p e0249344 (2021)
Purpose To examine the effect of prolactin (PRL) on human corneal stromal fibroblasts (CSFs), derived from healthy individuals and from keratoconus (KC) patients, in vitro, specifically assessing physiological and elevated PRL concentrations as appar
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0246375 (2021)
PLoS ONE, Vol 16, Iss 2, p e0246375 (2021)
Prostaglandin E2(PGE2)-induced coughsin vivoand vagal nerve depolarizationin vitroare inhibited by systemic and local administration of prostaglandin EP3 receptor (L-798106) and TRPV1 antagonists (JNJ 17203212). These results indicate a modulating ef
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0246213 (2021)
PLoS ONE, Vol 16, Iss 2, p e0246213 (2021)
Despite the need for safe and effective postoperative analgesia in neonates, research regarding pain management in neonatal rodents is relatively limited. Here, we investigate whether sustained release buprenorphine (Bup SR) effectively attenuates th
Autor:
Yemisi Dorcas Obafemi, Akinniyi Paul Akinduti, Joshua Adekunle Osiyemi, Adewale Gideon Adeyemi, Oluwaseun Ejilude, Temitope Temitayo Banjo, Maged El-Ashker, Patrick Omoregie Isibor
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0247013 (2021)
PLoS ONE, Vol 16, Iss 2, p e0247013 (2021)
Spread of genetically diverse Staphylococcus aureus characterized with multi-antibiotic resistance and regulated by high level agr functionalities in several communities in southwest Nigeria was investigated and evaluated for infection control. Staph
Autor:
Pradnya Dilip Chandanshive, Rashmi Ranjan Mohanty, Shree Ram Singh, Biswa Mohan Padhy, Somen Kumar Pradhan, Prasanta Raghab Mohapatra, Priyamadhaba Behera, Ravikumar S R, Arvind Kumar Singh, Binod Kumar Patro, Gitanjali Batmanabane, Shakti Kumar Bal, Siva Santosh Kumar Pentapati
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0247163 (2021)
PLoS ONE, Vol 16, Iss 2, p e0247163 (2021)
Background Ivermectin is one among several potential drugs explored for its therapeutic and preventive role in SARS-CoV-2 infection. The study was aimed to explore the association between ivermectin prophylaxis and the development of SARS-CoV-2 infec
Autor:
Pravati Pal, Bharathi Balakumar, Girwar Singh Gaur, Gopal Pal, Allampalli Sirisha, Zachariah Bobby
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245395 (2021)
PLoS ONE
PLoS ONE
Diabetic neuropathy is the most common complication affecting more than 50% of patients with longstanding diabetes. Till date, there are no reports to explain the scientific basis of alternative medicine as an adjunct therapy for treating diabetic ne
Autor:
Hans-Henrik Parving, Peter Gæde, Oluf Pedersen, Bernt Johan von Scholten, Stanley L. Hazen, Zeneng Wang, Tarunveer S. Ahluwalia, Signe Abitz Winther, Peter Rossing, Henrik Reinhard, Jens Ollgaard, Tine W. Hansen
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0244402 (2021)
Winther, S A, Øllgaard, J C, Hansen, T W, Von Scholten, B J, Reinhard, H, Ahluwalia, T S, Wang, Z, Gæde, P, Parving, H H, Hazen, S, Pedersen, O & Rossing, P 2021, ' Plasma trimethylamine N-oxide and its metabolic precursors and risk of mortality, cardiovascular and renal disease in individuals with type 2-diabetes and albuminuria ', PLoS ONE, vol. 16, no. 3, e0244402 . https://doi.org/10.1371/journal.pone.0244402
Winther, S A, Øllgaard, J C, Hansen, T W, Von Scholten, B J, Reinhard, H, Ahluwalia, T S, Wang, Z, Gæde, P, Parving, H H, Hazen, S, Pedersen, O & Rossing, P 2021, ' Plasma trimethylamine N-oxide and its metabolic precursors and risk of mortality, cardiovascular and renal disease in individuals with type 2-diabetes and albuminuria ', PLOS ONE, vol. 16, no. 3, e0244402 . https://doi.org/10.1371/journal.pone.0244402
PLoS ONE
Winther, S A, Øllgaard, J C, Hansen, T W, Von Scholten, B J, Reinhard, H, Ahluwalia, T S, Wang, Z, Gæde, P, Parving, H H, Hazen, S, Pedersen, O & Rossing, P 2021, ' Plasma trimethylamine N-oxide and its metabolic precursors and risk of mortality, cardiovascular and renal disease in individuals with type 2-diabetes and albuminuria ', PLoS ONE, vol. 16, no. 3, e0244402 . https://doi.org/10.1371/journal.pone.0244402
Winther, S A, Øllgaard, J C, Hansen, T W, Von Scholten, B J, Reinhard, H, Ahluwalia, T S, Wang, Z, Gæde, P, Parving, H H, Hazen, S, Pedersen, O & Rossing, P 2021, ' Plasma trimethylamine N-oxide and its metabolic precursors and risk of mortality, cardiovascular and renal disease in individuals with type 2-diabetes and albuminuria ', PLOS ONE, vol. 16, no. 3, e0244402 . https://doi.org/10.1371/journal.pone.0244402
PLoS ONE
Aims The trimethylamine N-oxide (TMAO) pathway is related to intestinal microbiota and has been associated to risk of cardiovascular disease (CVD). We investigated associations between four plasma metabolites in the TMAO pathway and risk of all-cause