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Autor:
J. P. Jones, William Parker, Caroline J. Smith, Zacharoula Konsoula, John Poulton, Jasmine Cendejas Hernandez, Navneet Suda
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0253543 (2021)
PLoS ONE, Vol 16, Iss 6, p e0253543 (2021)
Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders. We had previously postulated that acetaminophen exposure early in life, if combined with
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0246213 (2021)
PLoS ONE, Vol 16, Iss 2, p e0246213 (2021)
Despite the need for safe and effective postoperative analgesia in neonates, research regarding pain management in neonatal rodents is relatively limited. Here, we investigate whether sustained release buprenorphine (Bup SR) effectively attenuates th
Autor:
Hiroshi Yaginuma, Taku Tsunekawa, Keigo Taki, Takeshi Onoue, Runan Sun, Yoshihiro Ito, Shintaro Iwama, Tomoko Kobayashi, Ryoichi Banno, Hiroshi Arima, Daisuke Sakano, Daisuke Hagiwara, Hiroshi Takagi, Akira Mizoguchi, Shoen Kume, Tomonori Hirose, Hidetaka Suga, Mariko Sugiyama
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248065 (2021)
PLoS ONE
PLoS ONE
Excessive sodium salt (NaCl) or fat intake is associated with a variety of increased health risks. However, whether excessive NaCl intake accompanied by a high-fat diet (HFD) affects glucose metabolism has not been elucidated. In this study, C57BL/6J
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0242897 (2021)
PLoS ONE, Vol 16, Iss 2, p e0242897 (2021)
Circadian rhythms are entrained by light and influenced by non-photic stimuli, such as feeding. The activity preceding scheduled mealtimes, food anticipatory activity (FAA), is elicited in rodents fed a limited amount at scheduled times. FAA is thoug
Autor:
Fois, Adrien, Boucher-Lafleur, Anne-Marie, Thompson Legault, Julie, Renaud, Christian, Morin, Charles, Des Rosiers, Christine, Coderre, Lise, Laprise, Catherine, Lesage, Sylvie, LSFC Consortium
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 10, p e0239860 (2020)
PLoS ONE, Vol 15, Iss 10, p e0239860 (2020)
Leigh Syndrome French Canadian (LSFC) is a rare autosomal recessive metabolic disorder characterized by severe lactic acidosis crises and early mortality. LSFC patients carry mutations in the Leucine Rich Pentatricopeptide Repeat Containing (LRPPRC)
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0238208 (2020)
PLoS ONE, Vol 15, Iss 9, p e0238208 (2020)
IntroductionPeripheral nerve injury (PNI) often leads to significant functional loss in patients and poses a challenge to physicians since treatment options for improving functional outcomes are limited. Recent studies suggest that erythropoietin and
Autor:
Hesham S. Al-Sallami, Peter Galettis, Hani Al-Salami, Virginie Lam, Ryusuke Takechi, Emily Brook, John C.L. Mamo, Armin Mooranian, Edward Eden, Maimuna Majimbi
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0243858 (2021)
PLoS ONE, Vol 16, Iss 6, p e0243858 (2021)
Background Cannabidiol (CBD) confers therapeutic effects in some neurological disorders via modulation of inflammatory, oxidative and cell-signalling pathways. However, CBD is lipophilic and highly photooxidative with low oral bioavailability in plas
Autor:
Nashwa W. Yassa, Doaa A. Ghareeb, Sofia Khalil, Samar R. Saleh, Maha A. El Demellawy, Mohamed M. El-Sayed
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 8, p e0237929 (2020)
PLoS ONE, Vol 15, Iss 8, p e0237929 (2020)
BackgroundNeuroinflammation causes neurodegenerative conditions like Alzheimer's disease (AD). Ipriflavone (IP), therapeutic compound to postmenopausal osteoporosis, has limited estrogenic activity and is accounted as AChE inhibitor. The developing o
Autor:
Adriano Wang-Leandro, Katrin Beckmann, Aline R Steiner, Sven Haller, Inés Carrera, Matthias Dennler, Henning Richter, Rima N Bektas
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 4, p e0231955 (2020)
PLOS ONE, Vol. 15, No 4 (2020) P. e0231955
PLoS ONE, Vol 15, Iss 4, p e0231955 (2020)
PLOS ONE, Vol. 15, No 4 (2020) P. e0231955
Resting-state functional Magnetic Resonance Imaging (rs-fMRI) has become an established technique in humans and reliably determines several resting state networks (RSNs) simultaneously. Limited data exist about RSN in dogs. The aim of this study was
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 6, p e0235046 (2020)
PLoS ONE, Vol 15, Iss 6, p e0235046 (2020)
Post-ictal emergence of slow wave EEG (electroencephalogram) activity and burst-suppression has been associated with the therapeutic effects of the electroconvulsive therapy (ECT), indicating that mere “cerebral silence” may elicit antidepressant