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Autor:
J. P. Jones, William Parker, Caroline J. Smith, Zacharoula Konsoula, John Poulton, Jasmine Cendejas Hernandez, Navneet Suda
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0253543 (2021)
PLoS ONE, Vol 16, Iss 6, p e0253543 (2021)
Based on several lines of evidence, numerous investigators have suggested that acetaminophen exposure during early development can induce neurological disorders. We had previously postulated that acetaminophen exposure early in life, if combined with
Autor:
Cassandra M. Wilkinson, Tiffany F. C. Kung, Frederick Colbourne, Christine A. Dirks, Glen C. Jickling
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0252584 (2021)
PLoS ONE, Vol 16, Iss 6, p e0252584 (2021)
Intracerebral hemorrhage (ICH) is a devastating insult with few effective treatments. Edema and raised intracranial pressure contribute to poor outcome after ICH. Glibenclamide blocks the sulfonylurea 1 transient receptor potential melastatin 4 (Sur1
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 2, p e0246213 (2021)
PLoS ONE, Vol 16, Iss 2, p e0246213 (2021)
Despite the need for safe and effective postoperative analgesia in neonates, research regarding pain management in neonatal rodents is relatively limited. Here, we investigate whether sustained release buprenorphine (Bup SR) effectively attenuates th
Autor:
Ric M. Procyshyn, William G. Honer, Jessica W. Y. Yuen, Lurdes Tse, Alasdair M. Barr, Heidi N. Boyda
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0246211 (2021)
PLoS ONE
PLoS ONE
Background The second generation antipsychotic drugs represent the most common form of pharmacotherapy for schizophrenia disorders. It is now well established that most of the second generation drugs cause metabolic side-effects. Risperidone and its
Autor:
Ningyong Xu, Viktoriya Pastukh, Mikhail Alexeyev, Troy Stevens, Dhananjay T. Tambe, Linn Ayers
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250095 (2021)
PLoS ONE
PLoS ONE
Collective migration of endothelial cells is important for wound healing and angiogenesis. During such migration, each constituent endothelial cell coordinates its magnitude and direction of migration with its neighbors while retaining intercellular
Autor:
Swaha Satpathy, Arjun Patra, Bharti Ahirwar, Muhammad Delwar Hussain, Mohsin Kazi, Mohammed S. Aldughaim
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0240068 (2021)
PLoS ONE
PLoS ONE
Pueraria tuberosa (Roxb. ex Willd.) DC., known as Indian Kudzu belongs to family Fabaceae and it is solicited as “Rasayana” drugs in Ayurveda. In the present study, we analyzed the efficacy of an ethyl acetate fraction from the tuber extract of P
Autor:
Nicola Beltraminelli, Paul R. Pentel, Amy Saykao, Thomas Thisted, Zuzanna Biesova, Stéphanie Fallot, Stephen Horrigan, Steve Fuller, Darryl Sampey, Bin Zhou, Michael D. Raleigh, Matthew W. Kalnik, Mark G. LeSage
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254247 (2021)
PLoS ONE
PLoS ONE
Use of nicotine-specific monoclonal antibodies (mAbs) to sequester and reduce nicotine distribution to brain has been proposed as a therapeutic approach to treat nicotine addiction (the basis of tobacco use disorder). A series of monoclonal antibodie
Publikováno v:
PLoS ONE, Vol 16, Iss 10 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258939 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258939 (2021)
Urethane, an acute laboratory anesthetic, produces distinct neurophysiological and physiological effects creating an effective model of the dynamics of natural sleep. As a model of both sleep-like neurophysiological activity and the downstream periph
Autor:
Paolo S. D'Aquila, Adriana Galistu
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245559 (2021)
PLoS ONE
PLoS ONE
We previously reported that treatment with the prototypical antidepressant imipramine induced a dose-dependent reduction of the ingestion of a 10% sucrose solution, due to reduction of the licking burst number, thus suggesting reduced motivation and/
Autor:
Maria do Socorro de Sousa Cartágenes, José Osvaldo Barbosa Neto, João Batista Santos Garcia, Lyvia Maria Rodrigues de Sousa Gomes, Rayanne Luiza Tajra Mualem Araújo, Nicolau Gregori Czeczko
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245194 (2021)
PLoS ONE
PLoS ONE
Pharmacological treatment of osteoarthritis is still inadequate due to the low efficacy of the drugs used. Dexmedetomidine via the intra-articular (i.a.) route might be an option for the treatment of osteoarthritis-associated pain. The present study