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Publikováno v:
PLoS ONE, Vol 16, Iss 10 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258939 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258939 (2021)
Urethane, an acute laboratory anesthetic, produces distinct neurophysiological and physiological effects creating an effective model of the dynamics of natural sleep. As a model of both sleep-like neurophysiological activity and the downstream periph
Autor:
Maria do Socorro de Sousa Cartágenes, José Osvaldo Barbosa Neto, João Batista Santos Garcia, Lyvia Maria Rodrigues de Sousa Gomes, Rayanne Luiza Tajra Mualem Araújo, Nicolau Gregori Czeczko
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245194 (2021)
PLoS ONE
PLoS ONE
Pharmacological treatment of osteoarthritis is still inadequate due to the low efficacy of the drugs used. Dexmedetomidine via the intra-articular (i.a.) route might be an option for the treatment of osteoarthritis-associated pain. The present study
Autor:
Byung Kook Lee, Najmiddin Mamadjonov, Chun Song Youn, In Seok Jeong, Yong Il Min, Hyoung Youn Lee, Tag Heo, Yong Hun Jung, Kyung Woon Jeung
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0249794 (2021)
PLoS ONE, Vol 16, Iss 4, p e0249794 (2021)
Several studies have suggested that sympathetic overstimulation causes deleterious effects in septic shock. A previous study suggested that pralidoxime exerted a pressor effect through a mechanism unrelated to the sympathetic nervous system; this eff
Autor:
Paola Marcolongo, Federica Pessina, Fabio Fusi, Maria Frosini, Elena Dreassi, Beatrice Gorelli, Valeria Francardi, Massimo Valoti, Paolo Fiorenzani, Daniela Giustarini, Maurizio Botta, Simona Saponara, Alessandra Gamberucci
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0233788 (2020)
PLoS ONE, Vol 15, Iss 5, p e0233788 (2020)
In pre-hypertension, moderate control of blood pressure (BP) can be obtained by a nutritional approach. The effects of a diet enriched with defatted larvae of the mealworm Tenebrio molitor (Coleoptera: Tenebrionidae) (TM) endowed with ACE inhibitory
Autor:
Jirawan Thongbunchoo, Ketsaraporn Nammultriputtar, Jarinthorn Teerapornpuntakit, Kornkamon Lertsuwan, Narattaphol Charoenphandhu, Natnicha Tannop, Supanan Nanthawuttiphan
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0234009 (2020)
PLoS ONE, Vol 15, Iss 5, p e0234009 (2020)
One of the potential contributing factors for iron overload-induced osteoporosis is the iron toxicity on bone forming cells, osteoblasts. In this study, the comparative effects of Fe3+ and Fe2+ on osteoblast differentiation and mineralization were st
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 3, p e0230238 (2020)
PLoS ONE, Vol 15, Iss 3, p e0230238 (2020)
Social withdrawal in the sub-chronic phencyclidine (PCP) rat model, a behavioral correlate of the negative symptoms of schizophrenia, results from deficits in brain endocannabinoid transmission. As cannabis intake has been shown to affect negatively
Autor:
Kyung-Hyun Kim, Geum-Lan Hong, Da-Young Jung, Shanika Karunasagara, Ju-Young Jung, Kyoungwon Cho
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0236879 (2020)
PLoS ONE
PLoS ONE
Benign prostatic hyperplasia (BPH) is a progressive pathological condition associated with proliferation of prostatic tissues, prostate enlargement, and lower-urinary tract symptoms. However, the mechanism underlying the pathogenesis of BPH is unclea
Autor:
Anjali Vivek, Jared Wahl, Todd W. Vanderah, Thomas P. Davis, Kathryn L. Kellohen, Seph M. Palomino, Vani Verkhovsky, Tally M. Largent-Milnes, Erika Liktor-Busa, Kiera T. Blawn, Beth M Wiese
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 5, p e0227463 (2020)
PLoS ONE, Vol 15, Iss 5, p e0227463 (2020)
Disruption of blood-brain barrier integrity and dramatic failure of brain ion homeostasis including fluctuations of pH occurs during cortical spreading depression (CSD) events associated with several neurological disorders, including migraine with au
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 12, p e0226918 (2019)
PLoS ONE, Vol 14, Iss 12, p e0226918 (2019)
Recently, extensive efforts have been made to understand the importance of the extra-renal uric acid (UA) excretion pathways and their contribution to UA-related diseases. However, the method typically used to measure UA concentrations in the intesti
Autor:
Yves Henrotin, Sonia Escaich, Sébastien Pirson, Carelli Claude, R. Montjean, Raffaello Paolini, Thibaut Neutelings, Vetu Christelle
Publikováno v:
PLoS ONE
PLOS ONE
PLoS ONE, Vol 15, Iss 4, p e0231240 (2020)
PLOS ONE
PLoS ONE, Vol 15, Iss 4, p e0231240 (2020)
Objective REG-O3 is a 24-aminoacid chimeric peptide combining a sequence derived from growth hormone (GH) and an analog of somatostatin (SST), molecules displaying cartilage repair and anti-inflammatory properties, respectively. This study aimed to i