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Publikováno v:
PLoS ONE, Vol 15, Iss 9 (2020)
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0238464 (2020)
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0238464 (2020)
BackgroundActigraphs are wrist-worn devices that record tri-axial accelerometry data used clinically and in research studies. The expense of research-grade actigraphs, however, limit their widespread adoption, especially in clinical settings. Tri-axi
Publikováno v:
PLoS ONE, Vol 15, Iss 9 (2020)
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0239327 (2020)
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0239327 (2020)
In older adults with subjective memory complaints (SMCs), featuring a decline in memory but not exhibiting problems during medical examinations and objective memory tests, the weak links between nodes evident in the word retrieval process can be a pr
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242244 (2020)
PLoS ONE
PLoS ONE, Vol 15, Iss 11 (2020)
PLoS ONE
PLoS ONE, Vol 15, Iss 11 (2020)
Background Evidence shows that antiretroviral (ART) exposure is associated with neurodevelopmental delays in human immunodeficiency virus (HIV)-exposed uninfected (HEU) children. However, there are few insights into modifiable maternal and child fact
Autor:
Andrea Ferrigno, Luca Fabris, Stefano Perlini, Mariapia Vairetti, Luciano Adorini, Clarissa Berardo, Giuseppina Palladini, Plinio Richelmi, Laura Giuseppina Di Pasqua, Massimiliano Cadamuro
Publikováno v:
PLoS ONE, Vol 15, Iss 9 (2020)
PLoS ONE, Vol 15, Iss 9, p e0238543 (2020)
PLoS ONE
PLoS ONE, Vol 15, Iss 9, p e0238543 (2020)
PLoS ONE
BackgroundWe have previously shown that obeticholic acid (OCA) upregulates the biliary excretion of asymmetric dimethylarginine (ADMA), an inhibitor of iNOS regulating the activity of matrix metalloproteinases (MMPs). Here, the effects of OCA on MMP-
Autor:
Tineke E. Buffart, Jan Hein T.M. van Waesberghe, Henk M.W. Verheul, Jan Dirk Burggraaf, Gerrit A. Meijer, Daoud Sie, Maarten Neerincx, Nicole C.T. van Grieken, Cornelis Verhoef, Bauke Ylstra, Ram C. Shankaraiah, Paul P. Eijk, Mark A. van de Wiel, Floor S.W. Van Der Wolf-De Lijster, Dennis Poel
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201809 (2018)
PLoS ONE, 13(8). Public Library of Science
PLoS One (online), 13(8):e0201809. Public Library of Science
PLoS ONE
PLoS ONE, 13(8):e0201809, 1-20. Public Library of Science
Neerincx, M, Poel, D, Sie, D L S, van Grieken, N C T, Shankaraiah, R C, Van Der Wolf-De Lijster, F S W, van Waesberghe, J H T M, Burggraaf, J D, Eijk, P P, Verhoef, C, Ylstra, B, Meijer, G A, van de Wiel, M A, Buffart, T E & Verheul, H M W 2018, ' Combination of a six microRNA expression profile with four clinicopathological factors for response prediction of systemic treatment in patients with advanced colorectal cancer ', PLoS ONE, vol. 13, no. 8, e0201809, pp. 1-20 . https://doi.org/10.1371/journal.pone.0201809
Neerincx, M, Poel, D, Sie, D L S, van Grieken, N C T, Shankaraiah, R C, van der Wolf-de Lijster, F S W, van Waesberghe, J-H T M, Burggraaf, J-D, Eijk, P P, Verhoef, C, Ylstra, B, Meijer, G A, van de Wiel, M A, Buffart, T E & Verheul, H M W 2018, ' Combination of a six microRNA expression profile with four clinicopathological factors for response prediction of systemic treatment in patients with advanced colorectal cancer ', PLoS ONE, vol. 13, no. 8, pp. e0201809 . https://doi.org/10.1371/journal.pone.0201809
PLoS ONE, 13(8). Public Library of Science
PLoS One (online), 13(8):e0201809. Public Library of Science
PLoS ONE
PLoS ONE, 13(8):e0201809, 1-20. Public Library of Science
Neerincx, M, Poel, D, Sie, D L S, van Grieken, N C T, Shankaraiah, R C, Van Der Wolf-De Lijster, F S W, van Waesberghe, J H T M, Burggraaf, J D, Eijk, P P, Verhoef, C, Ylstra, B, Meijer, G A, van de Wiel, M A, Buffart, T E & Verheul, H M W 2018, ' Combination of a six microRNA expression profile with four clinicopathological factors for response prediction of systemic treatment in patients with advanced colorectal cancer ', PLoS ONE, vol. 13, no. 8, e0201809, pp. 1-20 . https://doi.org/10.1371/journal.pone.0201809
Neerincx, M, Poel, D, Sie, D L S, van Grieken, N C T, Shankaraiah, R C, van der Wolf-de Lijster, F S W, van Waesberghe, J-H T M, Burggraaf, J-D, Eijk, P P, Verhoef, C, Ylstra, B, Meijer, G A, van de Wiel, M A, Buffart, T E & Verheul, H M W 2018, ' Combination of a six microRNA expression profile with four clinicopathological factors for response prediction of systemic treatment in patients with advanced colorectal cancer ', PLoS ONE, vol. 13, no. 8, pp. e0201809 . https://doi.org/10.1371/journal.pone.0201809
BACKGROUND: First line chemotherapy is effective in 75 to 80% of patients with metastatic colorectal cancer (mCRC). We studied whether microRNA (miR) expression profiles can predict treatment outcome for first line fluoropyrimidine containing systemi
Autor:
Kerttu Majander, Pekka Taipale, Eero Kajantie, Pekka Marttinen, Katri Räikkönen, Anu-Katriina Pesonen, Esa Hämäläinen, Pia M. Villa, Jussi Gillberg, A. Inkeri Lokki, Maija Riitta Ordén, Hannele Laivuori
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174399 (2017)
PLoS ONE
PLoS ONE
Objectives Preeclampsia is divided into early-onset (delivery before 34 weeks of gestation) and late-onset (delivery at or after 34 weeks) subtypes, which may rise from different etiopathogenic backgrounds. Early-onset disease is associated with plac
Autor:
Marc Bazot, Giuseppe D'Ippolito, Wanderley Marques Bernardo, Ricardo Simoes, Ana Paula Carvalhal Moura, P.A. Ribeiro, Ulysses dos Santos Torres, Helizabet Salomao Abdalla Ayroza Ribeiro
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 8, p e0221499 (2019)
PLoS ONE, Vol 14, Iss 8, p e0221499 (2019)
Intestinal endometriosis is considered the most severe form of deep endometriosis, the rectosigmoid being involved in about 90% of cases of bowel infiltration. Transvaginal sonography (TVS) and magnetic resonance imaging (MRI) have been used for noni
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0218363 (2019)
PLoS ONE, Vol 14, Iss 6, p e0218363 (2019)
To investigate the characteristics and temporal changes in visual field defects (VFDs) in eyes with acute central retinal artery occlusion (CRAO).Retrospective, observational case series.A total of 119 patients diagnosed with acute non-arteritic CRAO
Autor:
Dongho Lee, Young Su Park, Gunn Huh, Joo Sung Kim, Hyuk Yoon, Nayoung Kim, Yoon Jin Choi, Cheol Min Shin
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 5, p e0216768 (2019)
PLoS ONE, Vol 14, Iss 5, p e0216768 (2019)
The use of biologics in inflammatory bowel disease (IBD) has increased recently. However, studies on whether the proportion of IBD patient visits to the emergency department (ED) has decreased are scarce. We investigated the trends in IBD-related ED
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 5, p e0218032 (2019)
PLoS ONE, Vol 14, Iss 5, p e0218032 (2019)
As a mismatch repair (MMR) gene, hMLH1 plays an important role in the maintenance of chromosomal integrity. Several studies have investigated the associations of hMLH1 -93GA (rs1800734) and Ile219Val (rs1799977) in diverse tumor types with discordant