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pro vyhledávání: ''
Autor:
Henriette Kirchner, Matthias H. Tschöp, Jenna Holland, Dhiraj G. Kabra, Paul T. Pfluger, Kristy M. Heppner
Publikováno v:
PLoS ONE; Vol 8
PLoS ONE 8:e61822 (2013)
PLoS ONE
PLoS ONE, Vol 8, Iss 4, p e61822 (2013)
PLoS ONE 8:e61822 (2013)
PLoS ONE
PLoS ONE, Vol 8, Iss 4, p e61822 (2013)
Type 2 Diabetes is a global health burden and based on current estimates will become an even larger problem in the future. Developing new strategies to prevent and treat diabetes is a scientific challenge of high priority. The stomach hormone ghrelin
Autor:
Johann Steiner, Jordan M. Ramsey, Nico J.M. van Beveren, F. Markus Leweke, Matthias Rothermundt, Paul C. Guest, Bernhard Bogerts, Emanuel Schwarz, Sabine Bahn
Publikováno v:
PLoS ONE; Vol 8
PLoS ONE
PLoS One (print), 8(11):e78729. Public Library of Science
PLoS ONE, Vol 8, Iss 11, p e78729 (2013)
PLoS ONE
PLoS One (print), 8(11):e78729. Public Library of Science
PLoS ONE, Vol 8, Iss 11, p e78729 (2013)
BACKGROUND: In schizophrenia, sex specific dimorphisms related to age of onset, course of illness and response to antipsychotic treatment may be mirrored by sex-related differences in the underlying molecular pathways. METHODOLOGY/PRINCIPAL FINDINGS:
Autor:
Catherine Fagard, Yazdan Yazdanpanah, Benoit Visseaux, Christine Katlama, Céline Colin, Jean-Michel Molina, Charlotte Charpentier, Anne-Marie Taburet, Diane Descamps, Christine Jacomet, Françoise Brun-Vézinet, Geneviève Chêne
Publikováno v:
PLoS ONE; Vol 8
PLoS ONE, Vol 8, Iss 1, p e53621 (2013)
PLoS ONE
PLoS ONE, Vol 8, Iss 1, p e53621 (2013)
PLoS ONE
OBJECTIVE: In the ANRS 139 TRIO trial, the use of 3 new active drugs (raltegravir, etravirine, and darunavir/ritonavir), resulted in a potent and sustained inhibition of viral replication in multidrug-resistant treatment-experienced patients. The aim
Autor:
Xuelian Yi, Claus Bachert, Juan Meng, Feng Liu, Shixi Liu, Yafeng Liu, Nan Zhang, Gabriele Holtappels, Peng Zhou
Publikováno v:
PLoS ONE; Vol 8
PLOS ONE
PLoS ONE
PLoS ONE, Vol 8, Iss 12, p e82373 (2013)
PLOS ONE
PLoS ONE
PLoS ONE, Vol 8, Iss 12, p e82373 (2013)
Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by both a chronic inflammation and tissue remodelling; as indicated by extracellular matrix protein deposition, basement membrane thickening, goblet cell hyperplasia and subepithelial
Autor:
Marco A. Martins, Marcelo Henrique dos Santos, Vinicius F. Carvalho, Patricia Mr. Silva, Daniella B. R. Insuela, Aline Bomfim Vieira, Luciana P. Coelho
Publikováno v:
PLoS ONE; Vol 8
PLoS ONE
PLoS ONE, Vol 8, Iss 8, p e71759 (2013)
PLoS ONE
PLoS ONE, Vol 8, Iss 8, p e71759 (2013)
Previous studies have described the antispasmodic effect of mangiferin, a natural glucoside xanthone (2-C-β-Dgluco-pyranosyl-1,3,6,7-tetrahydroxyxanthone) that is present in mango trees and other plants, but its mechanism of action remains unknown.
Autor:
András Székely, Emma Birkás, Sándor Rózsa, Ulrich Hegerl, György Purebl, Roland Mergl, Barna Konkolÿ Thege
Publikováno v:
PLoS ONE; Vol 8
PLoS ONE, Vol 8, Iss 9, p e75081 (2013)
PLoS ONE
PLoS ONE, Vol 8, Iss 9, p e75081 (2013)
PLoS ONE
BACKGROUND: The suicide rate in Hungary is high in international comparison. The two-year community-based four-level intervention programme of the European Alliance Against Depression (EAAD) is designed to improve the care of depression and to preven
Autor:
Antonio Vicino, Gennaro Prota, Fabio Fiorino, Donata Medaglini, Annalisa Ciabattini, Elena Pettini, Alessandro Boianelli, Gianni Pozzi
Publikováno v:
PLoS ONE; Vol 8
PLoS ONE
PLoS ONE, Vol 8, Iss 12, p e80545 (2013)
PLoS ONE
PLoS ONE, Vol 8, Iss 12, p e80545 (2013)
Primary T-cell activation at mucosal sites is of utmost importance for the development of vaccination strategies. T-cell priming after vaginal immunization, with ovalbumin and CpG oligodeoxynucleotide adjuvant as model vaccine formulation, was studie
Autor:
Thomas Bodmer, Jacques Schrenzel, Sebastien Gagneux, Jean-Paul Janssens, Matthias Hoffmann, Enos Bernasconi, Erik C. Böttger, Lukas Fenner, Matthias Cavassini, Jan Fehr, Peter Helbling, Matthias Egger
Publikováno v:
PLoS ONE; Vol 7
PLoS ONE
PLoS ONE, Vol 7, Iss 3, p e34186 (2012)
PLOS ONE, Vol. 7, No 3 (2012) P. e34186
PloS one
Fenner, Lukas; Gagneux, Sebastien; Janssens, Jean-Paul; Fehr, Jan; Cavassini, Matthias; Hoffmann, Matthias; Bernasconi, Enos; Schrenzel, Jacques; Bodmer, Thomas; Böttger, Erik C; Helbling, Peter; Egger, Matthias; for the Swiss HIV Cohort and Molecular Epidemiology of Tuberculo, (2012). Tuberculosis in HIV-Negative and HIV-Infected Patients in a Low-Incidence Country: Clinical Characteristics and Treatment Outcomes. PLoS ONE, 7(3), e34186. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0034186
Plos One, vol. 7, no. 3, pp. e34186
PLoS ONE
PLoS ONE, Vol 7, Iss 3, p e34186 (2012)
PLOS ONE, Vol. 7, No 3 (2012) P. e34186
PloS one
Fenner, Lukas; Gagneux, Sebastien; Janssens, Jean-Paul; Fehr, Jan; Cavassini, Matthias; Hoffmann, Matthias; Bernasconi, Enos; Schrenzel, Jacques; Bodmer, Thomas; Böttger, Erik C; Helbling, Peter; Egger, Matthias; for the Swiss HIV Cohort and Molecular Epidemiology of Tuberculo, (2012). Tuberculosis in HIV-Negative and HIV-Infected Patients in a Low-Incidence Country: Clinical Characteristics and Treatment Outcomes. PLoS ONE, 7(3), e34186. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0034186
Plos One, vol. 7, no. 3, pp. e34186
BACKGROUND: In Switzerland and other developed countries, the number of tuberculosis (TB) cases has been decreasing for decades, but HIV-infected patients and migrants remain risk groups. The aim of this study was to compare characteristics of TB in
Autor:
Magnus Gisslén, Anders Sönnerborg, Göran Bratt, Per Björkman, Håkan Ekvall, Mattias Mild, Annika C. Karlsson, Jan Albert
Publikováno v:
PLoS ONE; Vol 7
PLoS ONE
PLoS ONE; 7(3) (2012)
PLoS ONE, Vol 7, Iss 3, p e33484 (2012)
PLoS ONE
PLoS ONE; 7(3) (2012)
PLoS ONE, Vol 7, Iss 3, p e33484 (2012)
Transmitted drug resistance (TDR) is a clinical and epidemiological problem because it may contribute to failure of antiretroviral treatment. The prevalence of TDR varies geographically, and its prevalence in Sweden during the last decade has not bee
Autor:
Macklyn Kihembo, Lawrence Muhangi, Hellen Akurut, Moses Kizza, Barbara Apule, Robert Kizindo, Harriet Mpairwe, Juliet Ndibazza, Diana Rutebarika, Swaib A. Lule, Margaret Nampijja, Florence Akello, Katherine J. Alcock, Emily L. Webb, Patrice A. Mawa, Peter Naniima, Moses Muwanga, Dennison Kizito, Gloria Oduru, Alison M. Elliott, Robert Tweyongere
Publikováno v:
PLoS ONE; Vol 7
PLoS ONE, Vol 7, Iss 12, p e50325 (2012)
PLoS ONE
PLoS ONE, Vol 7, Iss 12, p e50325 (2012)
PLoS ONE
BACKGROUND: Helminth infections may modulate immune responses to unrelated pathogens and allergens; these effects may commence prenatally. We addressed the hypothesis that anthelminthic treatment in pregnancy and early childhood would improve respons