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Autor:
Elif Karaaslan, Aykut Ozdarendeli, Mehmet Ziya Doymaz, Ali Osman Kiliç, Faruk Karakeçili, Merve Kalkan-Yazıcı, Nesibe Selma Çetin, Sevde Hasanoğlu, Ahmet Kalkan
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0009973 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0009973 (2021)
In 2019, the World Health Organization declared 3 billion to be at risk of developing Crimean Congo Hemorrhagic Fever (CCHF). The causative agent of this deadly infection is CCHFV. The data related to the biology and immunology of CCHFV are rather sc
Autor:
Sylvain Mutanda, Medard Ilunga, Olaf Valverde Mordt, Digas Ngolo Tete, Wilfried Mutombo, Caecilia Schmid, Victor Kande, Séverine Blesson, Andrea Kuemmerle, Ismael Lumpungu, Christian Burri, Mays Kisala, Sonja Bernhard, Pathou Nganzobo
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009903 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 11 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 11 (2021)
PLoS Neglected Tropical Diseases
Background Nifurtimox-eflornithine combination therapy (NECT) for the treatment of second stage gambiense human African trypanosomiasis (HAT) was added to the World Health Organization’s Essential Medicines List in 2009 after demonstration of its n
Autor:
Li Sheng, Yan Zhang, Xiaoying Xu, Zongjie Hou, Jianghua Wang, Chong Chen, Xingming Ma, Yanping Luo, Qingxia Yang, Zhi Li, Qi He
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009927 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
The metacestode stage of Echinococcus granulosus can cause cystic echinococcosis (CE), which still widely occurs around the world. Since the early 1970s, benzimidazoles have been shown to inhibit the growth of cysts and used to treat CE. However, ben
Autor:
Omran Allatif, Noemia Mie Orii, Hélène Dutartre, Nicolas Futsch, Augusto César Penalva de Oliveira, Jorge Casseb, Brenda Rocamonde, Renaud Mahieux
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009940 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
The Human T-cell Leukemia Virus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a devastating neurodegenerative disease with no effective treatment, which affects an increasing number of people in Brazil. Immune cells from
Autor:
João Augusto Gomes de Souza Monteiro de Brito, Carlos Eduardo Pereira Corbett, Carla Andréa Avelar Pires, Claudia Maria de Castro Gomes, Débora Pinheiro Xavier, Marília Brasil Xavier, Gabriela Fernandes Rodrigues
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009887 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 11 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009887 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 11 (2021)
Background Brazil remains endemic for infection by the human immunodeficiency virus (HIV) and leprosy, having a major impact on public health and the life quality of affected patients. Although the relevance of this co-infection is recognized, severa
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009892 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009892 (2021)
Human African trypanosomiasis (HAT), also known as sleeping sickness, is a major cause of mortality and morbidity in sub-Saharan Africa. We hypothesised that recent findings of neurological features and parasite brain infiltration occurring at much e
Autor:
Amany Abdel Bary, Iman F. Abou-El-Naga, Eman Attia El-Morsy, Shereen F. Mossallam, Radwa G. Diab
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009866 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009866 (2021)
Extracellular vesicles (EVs) are protein-loaded nano-scaled particles that are extracellularly released by eukaryotes and prokaryotes. Parasite’s EVs manipulate the immune system, making them probable next-generation vaccines. Schistosomal EVs carr
Autor:
Joseph Verdi, Ana Rodriguez, Juan Rivera-Correa, Julian Sherman, Jeremy M Sternberg, Jayne Raper
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009814 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Anemia caused by trypanosome infection is poorly understood. Autoimmunity during Trypanosoma brucei infection was proposed to have a role during anemia, but the mechanisms involved during this pathology have not been elucidated. In mouse models and h
Autor:
Rajendranath Ramasawmy, José do Espírito Santo Junior, Thais Carneiro de Lacerda, Krys Layane Guimarães Duarte Queiroz, Tirza Gabrielle Ramos de Mesquita, Cláudio Marcello da Silveira Júnior, Mara Lúcia Gomes de Souza, Marcus Vinitius de Farias Guerra, Lissianne Augusta Matos Gomes, José Pereira de Moura Neto
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009795 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009795 (2021)
Leishmania are intracellular protozoan parasites that cause a wide spectrum of clinical manifestations in genetically susceptible individuals with an insufficient or balanced Th1 immune response to eliminate the parasite. MiRNAs play important regula
Autor:
Han Li, Hai Jiang, Mingjun Sun, Qiongqiong Bai, Dehui Yin, Jingpeng Zhang, Xiling Wu, Jihong Shao
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009695 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Background Brucellosis, as a serious zoonotic infectious disease, has been recognized as a re-emerging disease in the developing countries worldwide. In china, the incidence of brucellosis is increasing each year, seriously threatening the health of