Zobrazeno 1 - 10
of 137
pro vyhledávání: ''
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009490 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009490 (2021)
Treatment and control of schistosomiasis depends on a single drug, praziquantel, but this is not ideal for several reasons including lack of potency against the juvenile stage of the parasite, dose size, and risk of resistance. We have optimised the
Autor:
Tyler Warkentein, Jeevitha Mariapun, Syed M. Tupur Husain, Nevein Philip Botross Henien, Nor’azim Mohd Yunos, Wan Fadhilah Wan Ismail, Sharifah Syed Hassan, Amreeta Dhanoa, Lian Yih Pong, Hesham Elshahawi, Chin Fang Ngim, Robert D. Hontz, Nowrozy Kamar Jahan, Siti Aisyah Abdul Ahmad
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 5, p e0009445 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Background Dengue fever is the most common mosquito-borne infection worldwide where an expanding surveillance and characterization of this infection are needed to better inform the healthcare system. In this surveillance-based study, we explored the
Autor:
Euzenir Nunes Sarno, José Augusto da Costa Nery, Flávio Alves Lara, Mayara Abud Mendes, Pedro Henrique Lopes da Silva, Júlia Monteiro Pereira Leal, Mariana A. Hacker, Milton Ozório Moraes, Roberto Alves Lourenço, Danuza Esquenazi, Katherine Kelda Gomes de Castro, Thyago Leal Calvo
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009214 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009214 (2021)
Background Leprosy continues to be a public health problem in Brazil. Furthermore, detection rates in elderly people have increased, particularly those of multibacillary (L-Lep) patients, who are responsible for transmitting M. leprae. Part of the de
Autor:
María Belén Caputo, Graciela Bertocchi, Melisa D. Castro Eiro, Bruno Lococo, María Ailén Natale, María Cecilia Albareda, Susana A. Laucella, Todd Minning, María Gabriela Alvarez, Rick L. Tarleton, Gonzalo Cesar, María Josefina Elias
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0009473 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e0009473 (2021)
In chronic Chagas disease, Trypanosoma cruzi-specific T-cell function decreases over time, and alterations in the homeostatic IL-7/IL-7R axis are evident, consistent with a process of immune exhaustion. IL-27 is an important immunoregulatory cytokine
Autor:
Luisa Ruiz-Morales, Gabriela González-Prieto, Yoshihisa Hashiguchi, Alberto Paniz-Mondolfi, César G. Lemir, Federico Ramos, Sonia Moreno, Cecilia Parodi, María Celia Mora, Daniela Jaime, Sibila Monroig, Lourdes A. Delgado-Noguera, Josefina Beckar, Alejandra Barrio, María Fernanda García-Bustos
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0009003 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Background. To date, there is no specific literature available on the determinants for therapeutic failure (TF) with meglumine antimoniate (MA) in Northwestern-Argentina. This study aimed to identify epidemiological, clinical, and treatment-related f
Autor:
Georgia C. Atella, Patrícia Fampa, Monica F. Moreira, Willy Jablonka, A. Gaviraghi, Daniele S. Oliveira, Mário A.C. Silva-Neto, Cynara de Melo Rodovalho, Maria Beatriz S. Mota, Marcus F. Oliveira, Ana C.A. Melo, Stephanie Serafim de Carvalho, Rafael D. Mesquita, Thayane da Encarnação Sá-Guimarães, Rodrigo Dutra Nunes, Carlucio Rocha-Santos
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0008915 (2021)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
The adult females of Aedes aegypti mosquitoes are facultative hematophagous insects but they are unable to feed on blood right after pupae emergence. The maturation process that takes place during the first post-emergence days, hereafter named hemato
Autor:
Xiaozhao Li, Juntao Feng, Xinyue Hu, Yuanyuan Jiang, Wei Tang, Shuanglinzi Deng, Feifei Yin, Lisha Luo, Chengping Hu
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009508 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009508 (2021)
The complement system is activated in tuberculous pleural effusion (TPE), with increased levels of the anaphylatoxins stimulating pleural mesothelial cells (PMCs) to secrete chemokines, which recruit nonclassical monocytes to the pleural cavity. The
Autor:
Sarah O’Leary, Zach N. Adelman
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008971 (2020)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Aedes aegypti is a vector of dengue, chikungunya, and Zika viruses. Current vector control strategies such as community engagement, source reduction, and insecticides have not been sufficient to prevent viral outbreaks. Thus, interest in novel strate
Autor:
Felix Odhiambo Hayara, Joan Tonui, Jeremiah Khayumbi, Salim Allana, Daniel Matete, Benson G. Muchiri, Joshua Ongalo, Cheryl L. Day, Taryn A. McLaughlin, Neel R. Gandhi, Samuel Gurrion Ouma, Angela Campbell, Loren E. Sasser
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008764 (2020)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Schistosoma mansoni (SM) is a parasitic helminth that infects over 200 million people and causes severe morbidity. It undergoes a multi-stage life cycle in human hosts and as such stimulates a stage-specific immune response. The human T cell response
Autor:
Jipeng Wang, Wei Hu, Fang Luo, Yi Shen, Xumin Zhang, Jian Li, Bingkuan Zhu, Bin Xu, Wenbin Yang, Chengsong Sun, Yongdong Li, Xiaojin Mo
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008810 (2020)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Cercariae invasion of the human skin is the first step in schistosome infection. Proteases play key roles in this process. However, little is known about the related hydrolytic enzymes in Schistosoma japonicum. Here, we investigated the biochemical f