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Autor:
Elif Karaaslan, Aykut Ozdarendeli, Mehmet Ziya Doymaz, Ali Osman Kiliç, Faruk Karakeçili, Merve Kalkan-Yazıcı, Nesibe Selma Çetin, Sevde Hasanoğlu, Ahmet Kalkan
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0009973 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0009973 (2021)
In 2019, the World Health Organization declared 3 billion to be at risk of developing Crimean Congo Hemorrhagic Fever (CCHF). The causative agent of this deadly infection is CCHFV. The data related to the biology and immunology of CCHFV are rather sc
Autor:
Kathryn Crouch, Fiona Achcar, Federica Giordani, Annette MacLeod, Isabel M. Vincent, Pieter C. Steketee, Michael P. Barrett, Liam J. Morrison, Nicholas J. Dickens
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009939 (2021)
Steketee, P, Giordani, F, Vincent, I M, Crouch, K, Achcar, F, Dickens, N J, Morrison, L, MacLeod, A & Barrett, M P 2021, ' 'Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole ', PLoS Neglected Tropical Diseases, vol. 15, no. 11, e0009939 . https://doi.org/10.1371/journal.pntd.0009939
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009939 (2021)
Steketee, P, Giordani, F, Vincent, I M, Crouch, K, Achcar, F, Dickens, N J, Morrison, L, MacLeod, A & Barrett, M P 2021, ' 'Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole ', PLoS Neglected Tropical Diseases, vol. 15, no. 11, e0009939 . https://doi.org/10.1371/journal.pntd.0009939
Subspecies of the protozoan parasite Trypanosoma brucei are the causative agents of Human African Trypanosomiasis (HAT), a debilitating neglected tropical disease prevalent across sub-Saharan Africa. HAT case numbers have steadily decreased since the
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009949 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009949 (2021)
Cryptosporidium is a life-threating protozoan parasite belonging to the phylum Apicomplexa, which mainly causes gastroenteritis in a variety of vertebrate hosts. Currently, there is a re-emergence of Cryptosporidium infection; however, no fully effec
Autor:
Grisial H Roberts, Thomas A Gasan, Karl F. Hoffmann, Gilda Padalino, Shona Wilson, Iain W. Chalmers, Edridah M. Tukahebwa, Jakub Wawrzyniak, Josephine Forde-Thomas, Marije E Kuipers
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009981 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009981 (2021)
Funder: IBERS, Aberystwyth University PhD studentship
Funder: Higher Education Funding Council for Wales (HEFCW) - Global Challenges Research Fund (GCRF)
Extracellular Vesicles (EVs) are an integral component of cellular/organismal communic
Funder: Higher Education Funding Council for Wales (HEFCW) - Global Challenges Research Fund (GCRF)
Extracellular Vesicles (EVs) are an integral component of cellular/organismal communic
Autor:
Amany Abdel Bary, Iman F. Abou-El-Naga, Eman Attia El-Morsy, Shereen F. Mossallam, Radwa G. Diab
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009866 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009866 (2021)
Extracellular vesicles (EVs) are protein-loaded nano-scaled particles that are extracellularly released by eukaryotes and prokaryotes. Parasite’s EVs manipulate the immune system, making them probable next-generation vaccines. Schistosomal EVs carr
Autor:
Utpal Tatu, Vinithra Iyer, Sudeshna Majumdar, Sheetal Tushir, Rakesh Mishra, Srimonta Gayen, Shreekant Verma
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009810 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009810 (2021)
Hsp90 gene of G. lamblia has a split nature comprising two ORFs separated by 777 kb on chromosome 5. The ORFs of the split gene on chromosome 5 undergo transcription to generate independent pre-mRNAs that join by a unique trans-splicing reaction that
Autor:
Rajendranath Ramasawmy, José do Espírito Santo Junior, Thais Carneiro de Lacerda, Krys Layane Guimarães Duarte Queiroz, Tirza Gabrielle Ramos de Mesquita, Cláudio Marcello da Silveira Júnior, Mara Lúcia Gomes de Souza, Marcus Vinitius de Farias Guerra, Lissianne Augusta Matos Gomes, José Pereira de Moura Neto
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009795 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 9, p e0009795 (2021)
Leishmania are intracellular protozoan parasites that cause a wide spectrum of clinical manifestations in genetically susceptible individuals with an insufficient or balanced Th1 immune response to eliminate the parasite. MiRNAs play important regula
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009490 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009490 (2021)
Treatment and control of schistosomiasis depends on a single drug, praziquantel, but this is not ideal for several reasons including lack of potency against the juvenile stage of the parasite, dose size, and risk of resistance. We have optimised the
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 4, p e0009339 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 4, p e0009339 (2021)
Background Scrub typhus is a neglected tropical disease that threatens more than one billion people. If antibiotic therapy is delayed, often due to mis- or late diagnosis, the case fatality rate can increase considerably. Scrub typhus is caused by th
Autor:
Euzenir Nunes Sarno, José Augusto da Costa Nery, Flávio Alves Lara, Mayara Abud Mendes, Pedro Henrique Lopes da Silva, Júlia Monteiro Pereira Leal, Mariana A. Hacker, Milton Ozório Moraes, Roberto Alves Lourenço, Danuza Esquenazi, Katherine Kelda Gomes de Castro, Thyago Leal Calvo
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009214 (2021)
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009214 (2021)
Background Leprosy continues to be a public health problem in Brazil. Furthermore, detection rates in elderly people have increased, particularly those of multibacillary (L-Lep) patients, who are responsible for transmitting M. leprae. Part of the de