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pro vyhledávání: ''
Autor:
Mahdi Fallah, Xing Xu, Yu Tian, Trasias Mukama, Hermann Brenner, Elham Kharazmi, Kristina Sundquist, Jan Sundquist
Publikováno v:
PLoS Medicine, Vol 18, Iss 6, p e1003616 (2021)
PLoS Medicine
PLoS Medicine
Background Evidence-based guidance for starting ages of screening for first-degree relatives (FDRs) of patients with prostate cancer (PCa) to prevent stage III/IV or fatal PCa is lacking in current PCa screening guidelines. We aimed to provide eviden
Autor:
Johanna Wiik, Staffan Nilsson, Verena Sengpiel, Bo Jacobsson, Björn Strander, Cecilia Kärrberg
Publikováno v:
PLoS Medicine, Vol 18, Iss 5, p e1003641 (2021)
PLoS Medicine
PLoS Medicine
Background Treatment of cervical intraepithelial neoplasia (CIN) is associated with an increased risk of preterm delivery (PTD) although the exact pathomechanism is not yet understood. Women with untreated CIN also seem to have an increased risk of P
Autor:
Barbara Rusch, Linda Garcia Abrego, Mgcineni Ndlangamandla, Tombo Marie Luce, Nelly Staderini, Lorraine Pasipamire, Ramin Asgary, Simangele Mthethwa-Hleta, Elena Beideck, Bernhard Kerschberger, Paola Andrea Lopez Saavedra
Publikováno v:
PLoS Medicine, Vol 17, Iss 11, p e1003378 (2020)
PLoS Medicine
PLoS Medicine
Background Cervical cancer is among the most common preventable cancers with the highest morbidity and mortality. The World Health Organization (WHO) recommends visual inspection of the cervix with acetic acid (VIA) as cervical cancer screening strat
Autor:
Ilwoo Park, Seung Seog Han, Sung Eun Chang, Seong Hwan Kim, Gyeong Hun Park, Myoung Shin Kim, Jung Im Na, Ju Hee Lee, Woohyung Lim, Ik Jun Moon, Keewon Kim
Publikováno v:
PLoS Medicine, Vol 17, Iss 11, p e1003381 (2020)
PLoS Medicine
PLoS Medicine
Background The diagnostic performance of convolutional neural networks (CNNs) for diagnosing several types of skin neoplasms has been demonstrated as comparable with that of dermatologists using clinical photography. However, the generalizability sho
Autor:
Cristina Renzi, Meena Rafiq, Willie Hamilton, Gary A. Abel, Georgios Lyratzopoulos, Tra My Pham, Annie Herbert, Irene Petersen, Sarah Price
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 18, Iss 8, p e1003708 (2021)
Herbert, A, Rafiq, M, Pham, T M, Renzi, C, Abel, G A, Price, S, Hamilton, W, Petersen, I & Lyratzopoulos, G 2021, ' Predictive values for different cancers and inflammatory bowel disease of 6 common abdominal symptoms among more than 1.9 million primary care patients in the UK : A cohort study ', PLoS Medicine, vol. 18, no. 8, e1003708 . https://doi.org/10.1371/journal.pmed.1003708
Herbert, A, Rafiq, M, Pham, T M, Renzi, C, Abel, G A, Price, S, Hamilton, W, Petersen, I & Lyratzopoulos, G 2021, ' Predictive values for different cancers and inflammatory bowel disease of 6 common abdominal symptoms among more than 1.9 million primary care patients in the UK : A cohort study ', PLOS Medicine, vol. 18, no. 8, e1003708 . https://doi.org/10.1371/journal.pmed.1003708
PLoS Medicine, Vol 18, Iss 8, p e1003708 (2021)
Herbert, A, Rafiq, M, Pham, T M, Renzi, C, Abel, G A, Price, S, Hamilton, W, Petersen, I & Lyratzopoulos, G 2021, ' Predictive values for different cancers and inflammatory bowel disease of 6 common abdominal symptoms among more than 1.9 million primary care patients in the UK : A cohort study ', PLoS Medicine, vol. 18, no. 8, e1003708 . https://doi.org/10.1371/journal.pmed.1003708
Herbert, A, Rafiq, M, Pham, T M, Renzi, C, Abel, G A, Price, S, Hamilton, W, Petersen, I & Lyratzopoulos, G 2021, ' Predictive values for different cancers and inflammatory bowel disease of 6 common abdominal symptoms among more than 1.9 million primary care patients in the UK : A cohort study ', PLOS Medicine, vol. 18, no. 8, e1003708 . https://doi.org/10.1371/journal.pmed.1003708
Background The diagnostic assessment of abdominal symptoms in primary care presents a challenge. Evidence is needed about the positive predictive values (PPVs) of abdominal symptoms for different cancers and inflammatory bowel disease (IBD). Methods
Autor:
Andrew Y. Ng, Nicholas Bien, Safwan Halabi, Allison Park, David B. Larson, Matthew P. Lungren, Evan J. Zucker, Erik Jones, Jeremy Irvin, Geoffrey M. Riley, Robyn L. Ball, Michael Bereket, Curtis P. Langlotz, Pranav Rajpurkar, Gary S. Fanton, Kristen W. Yeom, Christopher F. Beaulieu, Russell Stewart, Bhavik N. Patel, Francis G. Blankenberg, Ricky Jones, Derek F. Amanatullah, Katie Shpanskaya
Publikováno v:
PLoS Medicine, Vol 15, Iss 11, p e1002699 (2018)
PLoS Medicine
PLoS Medicine
Background Magnetic resonance imaging (MRI) of the knee is the preferred method for diagnosing knee injuries. However, interpretation of knee MRI is time-intensive and subject to diagnostic error and variability. An automated system for interpreting
Autor:
Koichiro Yasaka, Osamu Abe
Publikováno v:
PLoS Medicine, Vol 15, Iss 11, p e1002707 (2018)
PLoS Medicine
PLoS Medicine
Autor:
Megan S. Rice, A. Heather Eliassen, Walter C. Willett, Shelley S. Tworoger, Graham A. Colditz, Amit Joshi, Bernard Rosner, Xuehong Zhang, Rulla M. Tamimi, Susan E. Hankinson, Sara Lindström, Peter Kraft, Jing Qian
Publikováno v:
PLoS Medicine, Vol 15, Iss 9, p e1002644 (2018)
BackgroundNo prior study to our knowledge has examined the joint contribution of a polygenic risk score (PRS), mammographic density (MD), and postmenopausal endogenous hormone levels-all well-confirmed risk factors for invasive breast cancer-to exist
Autor:
Matthew W Jenner, Mark T. Drayson, Alberto Rocci, John A. Snowden, Jindriska Lindsay, Gordon Cook, Mamta Garg, Martin Kaiser, Roger G. Owen, Ruth M. de Tute, Bhuvan Kishore, Gareth J. Morgan, Kamaraj Karunanithi, Faith E. Davies, Graham Jackson, Nigel H. Russell, Corinne Collett, John R Jones, David A Cairns, Charlotte Pawlyn, Anna Hockaday, Walter M Gregory, Cathy D. Williams
Publikováno v:
PLoS Medicine, Vol 18, Iss 1, p e1003454 (2021)
PLoS Medicine
PLoS Medicine
Background Carfilzomib is a second-generation irreversible proteasome inhibitor that is efficacious in the treatment of myeloma and carries less risk of peripheral neuropathy than first-generation proteasome inhibitors, making it more amenable to com
Autor:
Marija Pljesa-Ercegovac, Eithne Costello, Stephen W. Duffy, Hemant M. Kocher, William Greenhalf, Rhiannon Roberts, Asma S. Algahmdi, Oleg Blyuss, Núria Malats, Amina Saad, Alexander Ney, Harrison O’Brien, Grant D. Stewart, Silvana Debernardi, Stephen P. Pereira, Tatjana Crnogorac-Jurcevic
Publikováno v:
PLoS Medicine, Vol 17, Iss 12, p e1003489 (2020)
PLOS MEDICINE
PLoS Medicine
PLOS MEDICINE
PLoS Medicine
Background Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with around 9% of patients surviving >5 years. Asymptomatic in its initial stages, PDAC is mostly diagnosed late, when already a locally advanced or metastatic diseas