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Autor:
Amrit P. Singh, Frank Schmitz, Adam Z. Rosenthal, Madhav V. Dhodapkar, Antje Hoering, Daisy Alapat, Yan Ren, Maurizio Zangari, Kelsie Smith, Samuel A. Danziger, Jake Gockley, Andrew Dervan, Alexander V. Ratushny, Mark McConnell, Robert M. Hershberg, Suzana Couto, Brian A Walker, Faith E. Davies, Alison Fitch, Wilbert B. Copeland, Gareth J. Morgan, Bart Barlogie, Phil Farmer, David J. Reiss, Brian Fox, Mary H. Young, Frits van Rhee, Cody Ashby, Katie Newhall, Nathan Petty, Michael A Bauer, Robert Z. Orlowski, Matthew Trotter
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 17, Iss 11, p e1003323 (2020)
PLoS Medicine, Vol 17, Iss 11, p e1003323 (2020)
Background The tumor microenvironment (TME) is increasingly appreciated as an important determinant of cancer outcome, including in multiple myeloma (MM). However, most myeloma microenvironment studies have been based on bone marrow (BM) aspirates, w
Autor:
Elie Antoun, Negusse T Kitaba, Philip Titcombe, Kathryn V Dalrymple, Emma S Garratt, Sheila J Barton, Robert Murray, Paul T Seed, Joanna D Holbrook, Michael S Kobor, David Ts Lin, Julia L MacIsaac, Graham C Burdge, Sara L White, Lucilla Poston, Keith M Godfrey, Karen A Lillycrop, UPBEAT Consortium
Publikováno v:
PLoS Medicine
Antoun, E, Kitaba, N T, Titcombe, P, Dalrymple, K V, Garratt, E S, Barton, S J, Murray, R, Seed, P T, Holbrook, J D, Kobor, M S, Lin, D T S, MacIsaac, J L, Burdge, G C, White, S L, Poston, L & Godfrey, K M & Lillycrop, K A 2020, ' Maternal dysglycaemia, changes in the infant’s epigenome modified with a diet and physical activity intervention in pregnancy : Secondary analysis of a randomised control trial ', PLoS Medicine, vol. 17, no. 11, e1003229 . https://doi.org/10.1371/journal.pmed.1003229
PLoS Medicine, Vol 17, Iss 11, p e1003229 (2020)
Antoun, E, Kitaba, N T, Titcombe, P, Dalrymple, K V, Garratt, E S, Barton, S J, Murray, R, Seed, P T, Holbrook, J D, Kobor, M S, Lin, D T S, MacIsaac, J L, Burdge, G C, White, S L, Poston, L & Godfrey, K M & Lillycrop, K A 2020, ' Maternal dysglycaemia, changes in the infant’s epigenome modified with a diet and physical activity intervention in pregnancy : Secondary analysis of a randomised control trial ', PLoS Medicine, vol. 17, no. 11, e1003229 . https://doi.org/10.1371/journal.pmed.1003229
PLoS Medicine, Vol 17, Iss 11, p e1003229 (2020)
Background Higher maternal plasma glucose (PG) concentrations, even below gestational diabetes mellitus (GDM) thresholds, are associated with adverse offspring outcomes, with DNA methylation proposed as a mediating mechanism. Here, we examined the re
Autor:
Kathryn Therese. Mngadi, Vijay L. Mehra, Kristen W. Cohen, Glenda Gray, Shannon Grant, Zoe Moodie, Brodie Daniels, Marguerite Koutsoukos, Sanjay Phogat, Peter B. Gilbert, M. Juliana McElrath, Nonhlanhla N. Mkhize, Chenchen Yu, Georgia D. Tomaras, Olivier Van Der Meeren, Linda-Gail Bekker, James G. Kublin, Nicole Frahm, Carlos A. DiazGranados, Mary Allen, Lawrence Corey, Fatima Laher, Carter Bentley, Mookho Malahleha, Michael Pensiero, Lynn Morris, Kevin O. Saunders, Nicole L. Yates, Nicole Grunenberg, David C. Montefiori, Craig Innes
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 17, Iss 2, p e1003038 (2020)
PLoS Medicine, Vol 17, Iss 2, p e1003038 (2020)
Background HVTN 100 evaluated the safety and immunogenicity of an HIV subtype C pox-protein vaccine regimen, investigating a 12-month booster to extend vaccine-induced immune responses. Methods and findings A phase 1–2 randomized double-blind place
Autor:
Bruno H. Stricker, Dimitris Rizopoulos, Peter J. Koudstaal, Rikje Ruiter, Daniel Bos, Lana Fani, Kimberly D. van der Willik, M. Arfan Ikram, Maryam Kavousi, Maarten J.G. Leening, M. Kamran Ikram
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 17, Iss 5, p e1003115 (2020)
PLOS Medicine
PLoS Medicine, 17(5). Public Library of Science
PLoS Medicine, Vol 17, Iss 5, p e1003115 (2020)
PLOS Medicine
PLoS Medicine, 17(5). Public Library of Science
Background Atherosclerotic cardiovascular disease (ASCVD) is driven by multifaceted contributions of the immune system. However, the dysregulation of immune cells that leads to ASCVD is poorly understood. We determined the association of components o
Autor:
Yates, Tom A., Tomlinson, Laurie A., Bhaskaran, Krishnan, Langan, Sinead, Thomas, Sara, Smeeth, Liam, Douglas, Ian J.
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 14, Iss 11, p e1002457 (2017)
PLoS Medicine, Vol 14, Iss 11, p e1002457 (2017)
Background Recent in vitro and animal studies have found the proton pump inhibitor (PPI) lansoprazole to be highly active against Mycobacterium tuberculosis. Omeprazole and pantoprazole have no activity. There is no evidence that, in clinical practic
Autor:
Emma Toman, Robert J. Dinsdale, Janet M. Lord, Nicholas Crombie, Peter Hampson, David N Naumann, Antonio Belli, Paul Harrison, Jonathan R B Bishop, Zhangjie Su, Jon Hazeldine, David Davies, Niharika A. Duggal
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 14, Iss 7, p e1002338 (2017)
PLoS Medicine, Vol 14, Iss 7, p e1002338 (2017)
Background Almost all studies that have investigated the immune response to trauma have analysed blood samples acquired post-hospital admission. Thus, we know little of the immune status of patients in the immediate postinjury phase and how this migh
Autor:
Cabrera, CP, Manson, J, Shepherd, JM, Torrance, HD, Watson, D, Longhi, MP, Hoti, M, Patel, MB, O'Dwyer, M, Nourshargh, S, Pennington, DJ, Barnes, MR, Brohi, K
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 14, Iss 7, p e1002352 (2017)
PLoS Medicine, Vol 14, Iss 7, p e1002352 (2017)
Background Severe trauma induces a widespread response of the immune system. This “genomic storm” can lead to poor outcomes, including Multiple Organ Dysfunction Syndrome (MODS). MODS carries a high mortality and morbidity rate and adversely affe
Autor:
Gassen, N., Hartmann, J., Zschocke, J., Stepan, J., Hafner, K., Zellner, A., Kirmeier, T., Kollmannsberger, L., Wagner, K., Dedic, N., Balsevich, G., Deussing, J., Kloiber, S., Lucae, S., Holsboer, F., Eder, M., Uhr, M., Ising, M., Schmidt, M., Rein, T.
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 11, Iss 11, p e1001755 (2014)
PLOS MEDICINE
PLoS Medicine, Vol 11, Iss 11, p e1001755 (2014)
PLOS MEDICINE
Theo Rein and colleagues examine the role of FKBP51 in the actions of antidepressants, with a particular focus on pathways of autophagy. Please see later in the article for the Editors' Summary
Background FK506 binding protein 51 (FKBP51) is an
Background FK506 binding protein 51 (FKBP51) is an
Autor:
Joseph F. Sanchez, Kevin G. Becker, Jia Chen, William J. Freed, James Shen, Herbert M. Geller, Teruo Hayashi, Stacie L. Errico, Shang-Yi Tsai, Marilyn A Huestis, Tsung-Ping Su, Ross H. Lowe, Chun-Ting Lee, Rose Amable
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 5, Iss 6, p e117 (2008)
PLoS Medicine, Vol 5, Iss 6, p e117 (2008)
Background Prenatal exposure of the developing brain to cocaine causes morphological and behavioral abnormalities. Recent studies indicate that cocaine-induced proliferation inhibition and/or apoptosis in neural progenitor cells may play a pivotal ro
Autor:
Parikh, Samir M, Mammoto, Tadanori, Schultz, Aylit, Yuan, Hai-Tao, Christiani, David, Karumanchi, S. Ananth, Sukhatme, Vikas P
Publikováno v:
PLoS Medicine
Background Acute respiratory distress syndrome (ARDS) is a devastating complication of numerous underlying conditions, most notably sepsis. Although pathologic vascular leak has been implicated in the pathogenesis of ARDS and sepsis-associated lung i