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of 44
pro vyhledávání: ''
Autor:
Christopher J. Fields, Lu Li, Nicholas M. Hiers, Tianqi Li, Peike Sheng, Taha Huda, Jixiu Shan, Lauren Gay, Tongjun Gu, Jiang Bian, Michael S. Kilberg, Rolf Renne, Mingyi Xie
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 12, p e1009934 (2021)
PLoS Genetics, Vol 17, Iss 12, p e1009934 (2021)
MicroRNAs (miRNA) are short non-coding RNAs widely implicated in gene regulation. Most metazoan miRNAs utilize the RNase III enzymes Drosha and Dicer for biogenesis. One notable exception is the RNA polymerase II transcription start sites (TSS) miRNA
Autor:
Wuguo Deng, Han Yang, Dingbo Shi, Marc R. Gartenberg, Miao Chen, Changlin Zhang, Melinda S. Borrie, Qian Long, Haohui Sun
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 11, p e1009899 (2021)
PLoS Genetics, Vol 17, Iss 11, p e1009899 (2021)
The robust proliferation of cancer cells requires vastly elevated levels of protein synthesis, which relies on a steady supply of aminoacylated tRNAs. Delivery of tRNAs to the cytoplasm is a highly regulated process, but the machinery for tRNA nuclea
Autor:
Louise N. Reynard, Alexander D. Clark, Arthur G. Pratt, Richard Howey, Najib Naamane, Heather J. Cordell
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 9, p e1009811 (2021)
PLoS Genetics, Vol 17, Iss 9, p e1009811 (2021)
Bayesian networks can be used to identify possible causal relationships between variables based on their conditional dependencies and independencies, which can be particularly useful in complex biological scenarios with many measured variables. Here
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 7, p e1009675 (2021)
PLoS Genetics, Vol 17, Iss 7, p e1009675 (2021)
Emerging evidence indicates that tRNA-derived small RNAs (tsRNAs) are involved in fine-tuning gene expression and become dysregulated in various cancers. We recently showed that the 22nt LeuCAG3´tsRNA from the 3´ end of tRNALeu is required for effi
Autor:
David G. Huntsman, Yemin Wang, Alan Ying-Hsu Wang, Peter C. Stirling, James P. Wells, Yi Dan Zhu, Emily Yun-Chia Chang, Sean W. Minaker, Shuhe Tsai, Louis-Alexandre Fournier
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 4, p e1009238 (2021)
PLoS Genetics, Vol 17, Iss 4, p e1009238 (2021)
ARID1A is a core DNA-binding subunit of the BAF chromatin remodeling complex, and is lost in up to 7% of all cancers. The frequency of ARID1A loss increases in certain cancer types, such as clear cell ovarian carcinoma where ARID1A protein is lost in
Autor:
Robert V. Skibbens, Michael G. Mfarej
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 16, Iss 12, p e1009219 (2020)
PLoS Genetics, Vol 16, Iss 12, p e1009219 (2020)
Roberts syndrome (RBS) is a rare developmental disorder that can include craniofacial abnormalities, limb malformations, missing digits, intellectual disabilities, stillbirth, and early mortality. The genetic basis for RBS is linked to autosomal rece
Autor:
Flaviano Giorgini, Aisha M. Swaih, Anna Straatman-Iwanowska, Charalambos P. Kyriacou, Daniel C. Maddison, Mónica Alfonso-Núñez, Susanna Campesan, Natalie Allcock, Carlo Breda
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 16, Iss 11, p e1009129 (2020)
PLoS Genetics, Vol 16, Iss 11, p e1009129 (2020)
The enzyme kynurenine 3-monooxygenase (KMO) operates at a critical branch-point in the kynurenine pathway (KP), the major route of tryptophan metabolism. As the KP has been implicated in the pathogenesis of several human diseases, KMO and other enzym
Publikováno v:
PLoS Genetics
Publikováno v:
PLoS Genetics
Genomic imprinting is a parent-of-origin dependent phenomenon that restricts transcription to predominantly one parental allele. Since the discovery of the first long noncoding RNA (lncRNA), which notably was an imprinted lncRNA, a body of knowledge
Autor:
Derrick J. Morton, Sara W. Leung, Thaila Le, Rishi J. Nair, Khuong B. Nguyen, Anita H. Corbett, Binta Jalloh, J. Christopher Rounds, Maya C. Karkare, Kathryn D. McGaughey, Lily H. Kim, Maria C. Sterrett, Milo B. Fasken, Kenneth H. Moberg, Shaoyi Sheng, Isaac Kremsky, Brianna Brown
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 16, Iss 7, p e1008901 (2020)
PLoS Genetics, Vol 16, Iss 7, p e1008901 (2020)
The RNA exosome is an evolutionarily-conserved ribonuclease complex critically important for precise processing and/or complete degradation of a variety of cellular RNAs. The recent discovery that mutations in genes encoding structural RNA exosome su