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Autor:
Dämgen, MA, Biggin, PC
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 2, p e1007856 (2021)
PLoS Computational Biology, Vol 17, Iss 2, p e1007856 (2021)
Pentameric ligand-gated ion channels (pLGICs) are receptor proteins that are sensitive to their membrane environment, but the mechanism for how lipids modulate function under physiological conditions in a state dependent manner is not known. The glyc
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 3, p e1008825 (2021)
PLoS Computational Biology, Vol 17, Iss 3, p e1008825 (2021)
The activation and differentiation of T-cells are mainly directly by their co-regulatory receptors. T lymphocyte-associated protein-4 (CTLA-4) and programed cell death-1 (PD-1) are two of the most important co-regulatory receptors. Binding of PD-1 an
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 16, Iss 10, p e1007554 (2020)
Dubey, V, Bozorg, B, Wüstner, D & Khandelia, H 2020, ' Cholesterol binding to the sterol-sensing region of Niemann Pick C1 protein confines dynamics of its N-terminal domain ', PloS Computational Biology, vol. 16, no. 10, e1007554 . https://doi.org/10.1371/journal.pcbi.1007554
PLoS Computational Biology, Vol 16, Iss 10, p e1007554 (2020)
Dubey, V, Bozorg, B, Wüstner, D & Khandelia, H 2020, ' Cholesterol binding to the sterol-sensing region of Niemann Pick C1 protein confines dynamics of its N-terminal domain ', PloS Computational Biology, vol. 16, no. 10, e1007554 . https://doi.org/10.1371/journal.pcbi.1007554
Lysosomal accumulation of cholesterol is a hallmark of Niemann Pick type C (NPC) disease caused by mutations primarily in the lysosomal membrane protein NPC1. NPC1 contains a transmembrane sterol-sensing domain (SSD), which is supposed to regulate pr
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 1, p e1008474 (2021)
PLoS Computational Biology, Vol 17, Iss 1, p e1008474 (2021)
Intrinsically disordered regions (IDRs) are prevalent in the eukaryotic proteome. Common functional roles of IDRs include forming flexible linkers or undergoing allosteric folding-upon-binding. Recent studies have suggested an additional functional r
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 5, p e1008593 (2021)
PLoS Computational Biology
PLoS Computational Biology
The dynamic interactions between G protein-coupled receptors (GPCRs) and their cognate protein partners are central to several cell signaling pathways. For example, the association of CXC chemokine receptor 1 (CXCR1) with its cognate chemokine, inter
Autor:
Yong Duan, Alireza Tafazzol
Publikováno v:
PLoS Computational Biology
PLoS computational biology, vol 15, iss 10
PLoS Computational Biology, Vol 15, Iss 10, p e1007228 (2019)
PLoS computational biology, vol 15, iss 10
PLoS Computational Biology, Vol 15, Iss 10, p e1007228 (2019)
Toll-like receptors (TLRs) play a central role in both the innate and adaptive immune systems by recognizing pathogen-associated molecular patterns and inducing the release of the effector molecules of the immune system. The dysregulation of the TLR
Autor:
Westerlund, Annie M., Delemotte, Lucie
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 4, p e1006072 (2018)
PLoS Computational Biology
PLoS Computational Biology
Calmodulin (CaM) is a calcium sensing protein that regulates the function of a large number of proteins, thus playing a crucial part in many cell signaling pathways. CaM has the ability to bind more than 300 different target peptides in a Ca2+-depend
Autor:
Quentin Adams, Nicolas Henry, Vincent Raussens, Rouslan G. Efremov, François Van Liefferinge, Eva-Maria Krammer, Martine Prévost, Ellen Hubin, Florian Stengel, Rudolf Aebersold, Guy Vandenbussche, R. C. Chaves, Stéphanie Deroo
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 14, Iss 6, p e1006165 (2018)
PLoS computational biology, 14 (6
PLoS Computational Biology, 14 (6)
PLoS Computational Biology, 14(6):e1006165. Public Library of Science
PLoS Computational Biology, Vol 14, Iss 6, p e1006165 (2018)
PLoS computational biology, 14 (6
PLoS Computational Biology, 14 (6)
PLoS Computational Biology, 14(6):e1006165. Public Library of Science
Apolipoprotein E (apoE) is a forefront actor in the transport of lipids and the maintenance of cholesterol homeostasis, and is also strongly implicated in Alzheimer’s disease. Upon lipid-binding apoE adopts a conformational state that mediates the
Autor:
Rahul Gupta
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 14, Iss 2, p e1005984 (2018)
PLoS Computational Biology, Vol 14, Iss 2, p e1005984 (2018)
AMPA receptors (AMPARs) and their associations with auxiliary transmembrane proteins are bulky structures with large steric-exclusion volumes. Hence, self-crowding of AMPARs, depending on the local density, may affect their lateral diffusion in the p
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 10, Iss 7, p e1003714 (2014)
PLoS Computational Biology, Vol 10, Iss 7, p e1003714 (2014)
Cytochrome P450 enzymes are found in all life forms. P450s play an important role in drug metabolism, and have potential uses as biocatalysts. Human P450s are membrane-bound proteins. However, the interactions between P450s and their membrane environ