Zobrazeno 1 - 3
of 3
pro vyhledávání: ''
Computational design of improved standardized chemotherapy protocols for grade II oligodendrogliomas
Autor:
Luis E. Ayala-Hernández, Juan Belmonte-Beitia, Víctor M. Pérez-García, Andreas Raabe, Michael Murek, Philippe Schucht, Juan Manuel Sepúlveda
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 15, Iss 7, p e1006778 (2019)
PLoS Computational Biology, Vol 15, Iss 7, p e1006778 (2019)
Here we put forward a mathematical model describing the response of low-grade (WHO grade II) oligodendrogliomas (LGO) to temozolomide (TMZ). The model describes the longitudinal volumetric dynamics of tumor response to TMZ of a cohort of 11 LGO patie
Autor:
Marija Krstic-Demonacos, Kun Tian, Emyr Bakker, Jean-Marc Schwartz, Constantinos Demonacos, Luciano Mutti
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 13, Iss 11, p e1005825 (2017)
PLoS Computational Biology, Vol 13, Iss 11, p e1005825 (2017)
Glucocorticoid hormones (GCs) are used to treat a variety of diseases because of their potent anti-inflammatory effect and their ability to induce apoptosis in lymphoid malignancies through the glucocorticoid receptor (GR). Despite ongoing research,
Autor:
Murad Ookhtens, Andrew K. Smith, Brenden K. Petersen, Neil Kaplowitz, Ryan C. Kennedy, C. Anthony Hunt, Glen E. P. Ropella
Publikováno v:
PLoS Computational Biology
PLoS computational biology, vol 12, iss 12
PLoS Computational Biology, Vol 12, Iss 12, p e1005253 (2016)
PLoS computational biology, vol 12, iss 12
PLoS Computational Biology, Vol 12, Iss 12, p e1005253 (2016)
Acetaminophen-induced liver injury in mice is a model for drug-induced liver injury in humans. A precondition for improved strategies to disrupt and/or reverse the damage is a credible explanatory mechanism for how toxicity phenomena emerge and conve