Zobrazeno 1 - 10
of 22
pro vyhledávání: ''
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 6, p e1009145 (2021)
PLoS computational biology, vol 17, iss 6
PLoS Computational Biology, Vol 17, Iss 6, p e1009145 (2021)
PLoS computational biology, vol 17, iss 6
State-dependent sodium channel blockers are often prescribed to treat cardiac arrhythmias, but many sodium channel blockers are known to have pro-arrhythmic side effects. While the anti and proarrhythmic potential of a sodium channel blocker is thoug
Autor:
Jan B. Koenderink, Frans G. M. Russel, Ron H.J. Mathijssen, Marcel M. Verbeek, Laurens F. M. Verscheijden, Saskia N. de Wildt, Carlijn H. C. Litjens
Publikováno v:
Plos Computational Biology, 17
Plos Computational Biology, 17, 3
PLoS Computational Biology, 17(3):e1008786. Public Library of Science
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 3, p e1008786 (2021)
Plos Computational Biology, 17, 3
PLoS Computational Biology, 17(3):e1008786. Public Library of Science
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 3, p e1008786 (2021)
Morphine is a widely used opioid analgesic, which shows large differences in clinical response in children, even when aiming for equivalent plasma drug concentrations. Age-dependent brain disposition of morphine could contribute to this variability,
Autor:
Erli You, Parker W. de Waal, Karsten Melcher, H. Eric Xu, Jingjing Shi, Xiaoxi Wang, Bradley M. Dickson, Yi Jiang
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 16, Iss 4, p e1007394 (2020)
PLoS Computational Biology, Vol 16, Iss 4, p e1007394 (2020)
The development of novel analgesics with improved safety profiles to combat the opioid epidemic represents a central question to G protein coupled receptor structural biology and pharmacology: What chemical features dictate G protein or β-arrestin s
Computational design of improved standardized chemotherapy protocols for grade II oligodendrogliomas
Autor:
Luis E. Ayala-Hernández, Juan Belmonte-Beitia, Víctor M. Pérez-García, Andreas Raabe, Michael Murek, Philippe Schucht, Juan Manuel Sepúlveda
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 15, Iss 7, p e1006778 (2019)
PLoS Computational Biology, Vol 15, Iss 7, p e1006778 (2019)
Here we put forward a mathematical model describing the response of low-grade (WHO grade II) oligodendrogliomas (LGO) to temozolomide (TMZ). The model describes the longitudinal volumetric dynamics of tumor response to TMZ of a cohort of 11 LGO patie
Publikováno v:
Plos Computational Biology, 15, e1007117
PLoS Computational Biology, 15(6):e1007117. Public Library of Science
Plos Computational Biology, 15, 6, pp. e1007117
PLoS Computational Biology
PLoS Computational Biology, Vol 15, Iss 6, p e1007117 (2019)
PLoS Computational Biology, 15(6):e1007117. Public Library of Science
Plos Computational Biology, 15, 6, pp. e1007117
PLoS Computational Biology
PLoS Computational Biology, Vol 15, Iss 6, p e1007117 (2019)
Different pediatric physiologically-based pharmacokinetic (PBPK) models have been described incorporating developmental changes that influence plasma drug concentrations. Drug disposition into cerebrospinal fluid (CSF) is also subject to age-related
Autor:
Martin Tristani-Firouzi, Gunnar Seemann, Ricardo A. Navarro-Polanco, Frank B. Sachse, Robin Moss, Eloy G. Moreno-Galindo
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 14, Iss 10, p e1006438 (2018)
PLoS Computational Biology, Vol 14, Iss 10, p e1006438 (2018)
The cardiac muscarinic receptor (M2R) regulates heart rate, in part, by modulating the acetylcholine (ACh) activated K+ current IK,ACh through dissociation of G-proteins, that in turn activate KACh channels. Recently, M2Rs were noted to exhibit intri
Autor:
Simon Fontanel, Suzanne Peyrottes, Lars Peter Jordheim, Laurent Chaloin, Rahila Rahimova, Corinne Lionne
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, 2018, 14 (1), pp.e1005943. ⟨10.1371/journal.pcbi.1005943⟩
PLoS Computational Biology, Public Library of Science, 2018, 14 (1), pp.e1005943. ⟨10.1371/journal.pcbi.1005943⟩
PLoS Computational Biology, Vol 14, Iss 1, p e1005943 (2018)
PLoS Computational Biology, 2018, 14 (1), pp.e1005943. ⟨10.1371/journal.pcbi.1005943⟩
PLoS Computational Biology, Public Library of Science, 2018, 14 (1), pp.e1005943. ⟨10.1371/journal.pcbi.1005943⟩
PLoS Computational Biology, Vol 14, Iss 1, p e1005943 (2018)
The ecto-5’-nucleotidase CD73 plays an important role in the production of immune-suppressive adenosine in tumor micro-environment, and has become a validated drug target in oncology. Indeed, the anticancer immune response involves extracellular AT
Autor:
Marija Krstic-Demonacos, Kun Tian, Emyr Bakker, Jean-Marc Schwartz, Constantinos Demonacos, Luciano Mutti
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 13, Iss 11, p e1005825 (2017)
PLoS Computational Biology, Vol 13, Iss 11, p e1005825 (2017)
Glucocorticoid hormones (GCs) are used to treat a variety of diseases because of their potent anti-inflammatory effect and their ability to induce apoptosis in lymphoid malignancies through the glucocorticoid receptor (GR). Despite ongoing research,
Autor:
Sam A. Deadwyler, Vasilis Z. Marmarelis, Robert E. Hampson, Dustin Fetterhoff, Roman A. Sandler
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 13, Iss 7, p e1005624 (2017)
PLoS Computational Biology, Vol 13, Iss 7, p e1005624 (2017)
Much of the research on cannabinoids (CBs) has focused on their effects at the molecular and synaptic level. However, the effects of CBs on the dynamics of neural circuits remains poorly understood. This study aims to disentangle the effects of CBs o
Autor:
Murad Ookhtens, Andrew K. Smith, Brenden K. Petersen, Neil Kaplowitz, Ryan C. Kennedy, C. Anthony Hunt, Glen E. P. Ropella
Publikováno v:
PLoS Computational Biology
PLoS computational biology, vol 12, iss 12
PLoS Computational Biology, Vol 12, Iss 12, p e1005253 (2016)
PLoS computational biology, vol 12, iss 12
PLoS Computational Biology, Vol 12, Iss 12, p e1005253 (2016)
Acetaminophen-induced liver injury in mice is a model for drug-induced liver injury in humans. A precondition for improved strategies to disrupt and/or reverse the damage is a credible explanatory mechanism for how toxicity phenomena emerge and conve