Zobrazeno 1 - 10
of 18
pro vyhledávání: ''
Autor:
Connor G. G. Bamford, Milagros Rodriguez Collados, Alfredo Castello, Srikeerthana Kuchi, David Robertson, Nardus Mollentze, Sam J. Wilson, Joseph Busby, Arthur Wickenhagen, Douglas G. Stewart, Richard J. Orton, Siddharth Bakshi, Quan Gu, Elena Sugrue, Matthew L. Turnbull, Daniel G. Streicker, Massimo Palmarini, Suzannah J. Rihn, Andrew Shaw, Ana Filipe da Silva, Paul C. D. Johnson, Katherine Smollett
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
Antiviral defenses can sense viral RNAs and mediate their destruction. This presents a challenge for host cells since they must destroy viral RNAs while sparing the host mRNAs that encode antiviral effectors. Here, we show that highly upregulated int
Autor:
Shuqin Li, Meiting Wang, Yingdong Song, Wei Zhang, Fanghong Shao, Xiaolin Liang, Ge Shan, Xiangting Wang, Junxia Lu, Bowen Zhang, Meng Gong, Wei Wang, Yan Jin, Zhi Zhang
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 6, p e3001297 (2021)
PLoS Biology, Vol 19, Iss 6, p e3001297 (2021)
Recent studies have shown that long noncoding RNAs (lncRNAs) are critical regulators in the central nervous system (CNS). However, their roles in the cerebellum are currently unclear. In this work, we identified the isoform 204 of lncRNA Gm2694 (desi
Autor:
Laura E. Niklason, Bao Wang, Akiko Iwasaki, Richard W. Pierce, Nicholas C. Huston, Han Wan, Stephanie C. Eisenbarth, Tamas L. Horvath, Jennifer S. Chen, Victoria Habet, Renata B. Filler, Anna Marie Pyle, Victor Gasque, Neal G. Ravindra, Ryan D. Chow, Craig B. Wilen, Guilin Wang, Yuki Yasumoto, Mia Madel Alfajaro, Adam Williams, Allison M. Greaney, Ruth R. Montgomery, Ellen F. Foxman, Klara Szigeti-Buck, Jin Wei, David van Dijk, Sidi Chen
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 3, p e3001143 (2021)
PLoS Biology, Vol 19, Iss 3, p e3001143 (2021)
There are currently limited Food and Drug Administration (FDA)-approved drugs and vaccines for the treatment or prevention of Coronavirus Disease 2019 (COVID-19). Enhanced understanding of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Autor:
Ó’Maoiléidigh, Diarmuid S., van Driel, Annabel D., Singh, Anamika, Sang, Qing, Le Bec, Nolwenn, Vincent, Coral, de Olalla, Enric Bertran Garcia, Vayssières, Alice, Romera Branchat, Maida, Severing, Edouard, Martinez Gallegos, Rafael, Coupland, George
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 2, p e3001044 (2021)
PLoS Biology, Vol 19, Iss 2, p e3001044 (2021)
MicroRNAs (miRNAs) play important roles in regulating flowering and reproduction of angiosperms. Mature miRNAs are encoded by multiple MIRNA genes that can differ in their spatiotemporal activities and their contributions to gene regulatory networks,
Autor:
Christian R. Landry, Johan Hallin
Publikováno v:
PLoS Biology
PLoS Biology, Vol 17, Iss 11, p e3000519 (2019)
PLoS Biology, Vol 17, Iss 11, p e3000519 (2019)
A gene duplication can lead to all sorts of problems in a cell. However, it can also lead to all sorts of benefits. Beneficial or not, the gene duplicates might be kept in the genome because of several different reasons. For instance, if natural sele
Publikováno v:
PLoS Biology
PLoS Biology, Vol 17, Iss 11, p e3000289 (2019)
PLoS Biology, Vol 17, Iss 11, p e3000289 (2019)
Gene duplication promotes adaptive evolution in two main ways: allowing one duplicate to evolve a new function and splitting ancestral functions between the duplicates. The second scenario may resolve adaptive conflicts that can rise when one gene pe
Publikováno v:
PLoS Biology
PLoS Biology, Vol 17, Iss 11, p e3000481 (2019)
PLoS Biology, Vol 17, Iss 11, p e3000481 (2019)
Data normalization is a critical step in RNA sequencing (RNA-seq) analysis, aiming to remove systematic effects from the data to ensure that technical biases have minimal impact on the results. Analyzing numerous RNA-seq datasets, we detected a preva
Autor:
Madhavi D. Senagolage, Grant D. Barish, Amanda L. Allred, Christopher R. Futtner, Krithika Ramachandran, Meredith A. Sommars, Yasuhiro Omura
Publikováno v:
PLoS Biology
PLoS Biology, Vol 17, Iss 10, p e3000467 (2019)
PLoS Biology, Vol 17, Iss 10, p e3000467 (2019)
Skeletal muscles consist of fibers of differing metabolic activities and contractility, which become remodeled in response to chronic exercise, but the epigenomic basis for muscle identity and adaptation remains poorly understood. Here, we used chrom
Autor:
Rhonda Bacher, Doina Ciobanu, Igor V. Grigoriev, Leah E. Escalante, Feiqiao Brian Yu, Megan N. McClean, James Hose, Christina Kendziorski, Michael Place, Laura Sandor, Stephen R. Quake, Jad Kanbar, Audrey P. Gasch
Publikováno v:
PLoS Biology
PLoS Biology, Vol 15, Iss 12, p e2004050 (2017)
PLoS biology, vol 15, iss 12
Gasch, AP; Yu, FB; Hose, J; Escalante, LE; Place, M; Bacher, R; et al.(2017). Single-cell RNA sequencing reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress. PLoS Biology, 15(12). doi: 10.1371/journal.pbio.2004050. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/9hd480k9
PLoS Biology, Vol 15, Iss 12, p e2004050 (2017)
PLoS biology, vol 15, iss 12
Gasch, AP; Yu, FB; Hose, J; Escalante, LE; Place, M; Bacher, R; et al.(2017). Single-cell RNA sequencing reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress. PLoS Biology, 15(12). doi: 10.1371/journal.pbio.2004050. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/9hd480k9
From bacteria to humans, individual cells within isogenic populations can show significant variation in stress tolerance, but the nature of this heterogeneity is not clear. To investigate this, we used single-cell RNA sequencing to quantify transcrip
Autor:
Aravind Subramanian, David L. Lahr, Rajiv Narayan, John G. Doench, Ted Natoli, Peyton Greenside, Todd R. Golub, David E. Root, David Wadden, Itay Tirosh, Ian Smith
Publikováno v:
PLoS Biology
PLoS Biology, Vol 15, Iss 11, p e2003213 (2017)
PLoS Biology, Vol 15, Iss 11, p e2003213 (2017)
The application of RNA interference (RNAi) to mammalian cells has provided the means to perform phenotypic screens to determine the functions of genes. Although RNAi has revolutionized loss-of-function genetic experiments, it has been difficult to sy