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Autor:
Connor G. G. Bamford, Milagros Rodriguez Collados, Alfredo Castello, Srikeerthana Kuchi, David Robertson, Nardus Mollentze, Sam J. Wilson, Joseph Busby, Arthur Wickenhagen, Douglas G. Stewart, Richard J. Orton, Siddharth Bakshi, Quan Gu, Elena Sugrue, Matthew L. Turnbull, Daniel G. Streicker, Massimo Palmarini, Suzannah J. Rihn, Andrew Shaw, Ana Filipe da Silva, Paul C. D. Johnson, Katherine Smollett
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
Antiviral defenses can sense viral RNAs and mediate their destruction. This presents a challenge for host cells since they must destroy viral RNAs while sparing the host mRNAs that encode antiviral effectors. Here, we show that highly upregulated int
Autor:
George Zacharopoulos, Francesco Sella, Roi Cohen Kadosh, Kathrin Cohen Kadosh, Uzay E. Emir, Charlotte E. Hartwright
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 7, p e3001325 (2021)
PLoS Biology, Vol 19, Iss 7, p e3001325 (2021)
Previous research has highlighted the role of glutamate and gamma-aminobutyric acid (GABA) in learning and plasticity. What is currently unknown is how this knowledge translates to real-life complex cognitive abilities that emerge slowly and how the
Autor:
Natalia Garcia Escude, Hanafy M. Ismail, Mark I. Paine, Mariana Silva dos Santos, Vincent O. Adung'a, Raquel J. Vionette-Amaral, Shannon Quek, James I. MacRae, Clair Rose, Simon C. Wagstaff, Lee R. Haines, Daniel K. Masiga, Aitor Casas-Sanchez, Laith Yakob, Pedro L. Oliveira, Seth M. Barribeau, Alvaro Acosta-Serrano, Marcos Sterkel
Publikováno v:
PLoS Biology
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
PLOS BIOLOGY
PLoS Biology, Vol 19, Iss 1, p e3000796 (2021)
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
PLOS BIOLOGY
PLoS Biology, Vol 19, Iss 1, p e3000796 (2021)
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic insecticides
Autor:
Chenghui Song, Cesare Orlandi, Keqiang Xie, Kirill A. Martemyanov, Brian S. Muntean, Olga Ostrovskaya, Maria Dao, Laurie P. Sutton, Stefano Zucca
Publikováno v:
PLoS Biology
PLoS Biology, Vol 17, Iss 10, p e3000477 (2019)
PLoS Biology, Vol 17, Iss 10, p e3000477 (2019)
The striatum plays a fundamental role in motor learning and reward-related behaviors that are synergistically shaped by populations of D1 dopamine receptor (D1R)- and D2 dopamine receptor (D2R)-expressing medium spiny neurons (MSNs). How various neur
Autor:
Lieselotte Vande Walle, Sayumi Yamazoe, Libor Kostka, Jan Konvalinka, Steven T. Staben, Victoria Pham, Dieter Demon, Craig Stivala, Irma B. Stowe, Amelie Fossoul, Mohamed Lamkanfi, Filip Van Hauwermeiren, Pedro Henrique Viana Saavedra, Vladimir Subrt, Pavel Šácha, Nobuhiko Kayagaki, Bettina L. Lee, Petr Šimon
Publikováno v:
PLoS Biology
PLoS Biology, Vol 17, Iss 9, p e3000354 (2019)
PLOS BIOLOGY
PLOS Biology
PLoS Biology, Vol 17, Iss 9, p e3000354 (2019)
PLOS BIOLOGY
PLOS Biology
The nucleotide-binding-domain (NBD)–and leucine-rich repeat (LRR)–containing (NLR) family, pyrin-domain–containing 3 (NLRP3) inflammasome drives pathological inflammation in a suite of autoimmune, metabolic, malignant, and neurodegenerative dis
Publikováno v:
PLoS Biology
PLoS Biology, Vol 16, Iss 11, p e2006577 (2018)
PLoS Biology, Vol 16, Iss 11, p e2006577 (2018)
The interferon (IFN)-mediated innate immune response is the first line of defense against viruses. However, an IFN-stimulated gene, the adenosine deaminase acting on RNA 1 (ADAR1), favors the replication of several viruses. ADAR1 binds double-strande
Publikováno v:
PLoS Biology
PLoS Biology, Vol 15, Iss 2, p e2000487 (2017)
PLoS Biology, Vol 15, Iss 2, p e2000487 (2017)
Failure in cancer drug development exacts heavy burdens on patients and research systems. To investigate inefficiencies and burdens in targeted drug development in cancer, we conducted a systematic review of all prelicensure trials for the anticancer
Publikováno v:
PLoS Biology
PLoS Biology, Vol 14, Iss 12, p e1002586 (2016)
PLoS Biology, Vol 14, Iss 12, p e1002586 (2016)
Massive activation of dopamine neurons is critical for natural reward and drug abuse. In contrast, the significance of their spontaneous activity remains elusive. In Drosophila melanogaster, depolarization of the protocerebral anterior medial (PAM) c