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Autor:
Privita Edwina Rayappan George Edwin, Sumeet Kumar, Srestha Roy, Basudev Roy, Saumendra Kumar Bajpai
Publikováno v:
Physical biology. 20(1)
Tumor-associated collagen signature-3 (TACS-3) is a prognostic indicator for breast cancer survival. It is characterized by highly organized, parallel bundles of collagen fibers oriented perpendicular to the tumor boundary, serving as directional, co
Autor:
Asma Badrah, Salma Al-Tuwairqi
Publikováno v:
Physical biology. 19(5)
This paper aims to mathematically model the dynamics of Parkinson’s disease with therapeutic strategies. The constructed model consists of five state variables: healthy neurons, infected neurons, extracellular α-syn, active microglia, and resting
Publikováno v:
Physical biology. 19(5)
There have been a number of pharmaceutical and non-pharmaceutical interventions associated with COVID-19 over the past two years. Various non-pharmaceutical interventions were proposed and implemented to control the spread of the COVID-19 pandemic. M
Publikováno v:
Carugno, G, Neri, I & Vivo, P 2022, ' Instabilities of complex fluids with partially structured and partially random interactions ', Physical Biology, vol. 19, no. 5, 056001 . https://doi.org/10.1088/1478-3975/ac55f9
We develop a theory for thermodynamic instabilities of complex fluids composed of many interacting chemical species organised in families. This model includes partially structured and partially random interactions and can be solved exactly using tool
Autor:
Daniel Charlebois, Joshua Guthrie
Publikováno v:
Physical Biology. 19:066002
Rising rates of resistance to antimicrobial drugs threaten the effective treatment of infections across the globe. Drug resistance has been established to emerge from non-genetic mechanisms as well as from genetic mechanisms. However, it is still unc
Autor:
Jasmine Foo, David Basanta, Russell C Rockne, Carly Strelez, Curran Shah, Kimya Ghaffarian, Shannon M Mumenthaler, Kelly Mitchell, Justin D Lathia, David Frankhouser, Sergio Branciamore, Ya-Huei Kuo, Guido Marcucci, Robert Vander Velde, Andriy Marusyk, Sui Huang, Kishore Hari, Mohit Kumar Jolly, Haralampos Hatzikirou, Kamrine E Poels, Mary E Spilker, Blerta Shtylla, Mark Robertson-Tessi, Alexander R A Anderson
Publikováno v:
Physical biology. 19(3)
The role of plasticity and epigenetics in shaping cancer evolution and response to therapy has taken center stage with recent technological advances including single cell sequencing. This roadmap article is focused on state-of-the-art mathematical an
Publikováno v:
Physical Biology. 19:056003
It is widely believed that biological tissues evolved to lower the risks of cancer development. One of the specific ways to minimize the chances of tumor formation comes from proper spatial organization of tissues. However, the microscopic mechanisms
Autor:
Mark Leake
Publikováno v:
Physical Biology. 19:050201
Early career researcher (ECR) development is a dynamic challenge that tensions the urge to perform ground-breaking research against an ultimate practical aspiration of establishing an acceptable level of job security. There is no typical career path
Publikováno v:
Physical Biology. 19:043001
The architecture of an organ is built through interactions between its native cells and its connective tissue consisting of stromal cells and the extracellular matrix (ECM). Upon transformation through tumorigenesis, such interactions are disrupted a
Publikováno v:
Physical Biology. 19:041001
Effective treatments that prevent or reduce drug relapse vulnerability should be developed to relieve the high burden of drug addiction on society. This will only be possible by enhancing the understanding of the molecular mechanisms underlying the n