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Autor:
Theodosios Saranteas, Christina Tesseromatis, Iordanis Mourouzis, Georgia Kostopanagiotou, Dennis V. Cokkinos, Constantinos Mourouzis, Constantinos Pantos, Chariclia Karageorgiou, Dennis Varonos
Publikováno v:
Pharmacologytoxicology. 93(6)
The present study investigated the effects of mepivacaine on the response of rat aorta to vasoconstrictors in normal and aortic-banded animals. Cardiac hypertrophy was induced in Wistar rats by aortic banding, while sham-operated animals served as co
Publikováno v:
Pharmacologytoxicology. 93(5)
Microdialysis was used to sample extracellular unbound concentrations of alovudine in order to study the influence of well-known transport inhibitors (probenecid and quinidine) on the transport of alovudine between the blood and the brain extracellul
Autor:
Domingo Navarro, Agustin Dominguez-Diez, Juan Ramón Hernández Hernández, José María Díaz, Rosa Palomar, Guillermo García‐Plaza, Manuel Zumbado, Luis D. Boada
Publikováno v:
Pharmacologytoxicology. 93(5)
The protective effect of the 21-aminosteroid U-74389G was studied in an experimental model of partial ischaemia reperfusion liver injury. Previous studies have proven the remarkable potency of 21-aminosteroids to prevent oxidant-induced cell injury i
Publikováno v:
Pharmacologytoxicology. 89(3)
The effects of a neuroprotective agent 4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy) pyrimidine hydrochloride (NS-7) on the Ca(2+) currents in rat dorsal root ganglion neurones and on the depolarization-evoked nitric oxide synthesis, which wa
Autor:
Masafumi Yabuuchi, Isamu Nose, Tsugutaka Ito, Yasuyuki Mizuki, Katsuyoshi Nakatsuji, Yoshihide Kii
Publikováno v:
Pharmacologytoxicology. 89(2)
The purpose of this study was to examine the arrhythmogenic potential of 5-HT4 receptor agonists, cisapride and mosapride citrate (mosapride) in vivo. In anaesthetized rats, cisapride at intravenous infusion of 10 and 30 mg/kg/hr for 1 hr prolonged t
Publikováno v:
Pharmacologytoxicology. 89(1)
Administration of many antiepileptic drugs to patients with porphyria can precipitate an acute porphyric crisis. Information on the porphyrogenic activity of new antiepileptic drugs is still limited. In the presented study, the effects of tiagabine a
Autor:
Tina Kunz, Ernst H. Oliw
Publikováno v:
Pharmacologytoxicology. 88(5)
Treatment of rats with kainic acid (10 mg/kg, intraperitoneally) triggers limbic seizures. Cyclooxygenase-2 mRNA is expressed in the hippocampus and cortex after 8 hr and marked cell loss occurs after 72 hr in the CA1-CA3 areas of the hippocampus. We
Publikováno v:
Scopus-Elsevier
Cardiotoxicity is the major side-effect and limits the clinical use of the anthracyclines, doxorubicin and daunorubicin. A special problem is raised by the metabolites of these drugs, the amount of which may vary according to drug combinations and fo
Publikováno v:
Pharmacologytoxicology. 88(4)
The mechanisms responsible for amphotericin B nephrotoxicity remain incompletely understood, but clearly involve reduction in renal blood flow and glomerular filtration rate. Both direct effects of amphotericin B on contractile vascular cells, and in
Publikováno v:
Pharmacologytoxicology. 88(4)
The bioactivation and cytotoxicity of 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123), a replacement for some ozone-depleting chlorofluorocarbons, were investigated using freshly isolated hepatocytes from non-induced male rats. A time- and concentratio