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Publikováno v:
Pharmacologytoxicology. 88(4)
The control of myometrial contractility during pregnancy and parturition is not fully understood. Gas signalling molecules, such as nitric oxide and carbon monoxide, have been shown to relax the myometrium and may be involved in the control of contra
Publikováno v:
Pharmacologytoxicology. 85(5)
The Oxygen Diffusion Barrier Hypothesis states that aging in the liver is associated with restricted oxygen uptake that explains the age-related impairment of phase I drug clearance observed in vivo with preservation of in vitro phase I enzyme activi
The effect of toremifene on bone and uterine histology and on bone resorption in ovariectomised rats
Autor:
Eero Mäntylä, Stefan Karlsson, Lauri Kangas, Kirsti Nieminen, Seija Niemi, Lauri Nieminen, Y. Hirsimäki
Publikováno v:
Pharmacologytoxicology. 84(2)
The effect of the selective oestrogen receptor modulator, toremifene, to inhibit ovariectomy-induced bone loss was studied in rats. The oral doses were 0.3, 3.0 or 30 mg/kg/day for 2 months. 17beta-oestradiol (5 microg/kg/day, subcutaneously) was use
Publikováno v:
Pharmacologytoxicology. 79(1)
Earlier clinical and experimental studies have suggested that manganese-induced central nervous system dysfunction involves alterations in levels of dopamine, DA receptors, autoxidation of dopamine and generation of free radicals (Seth & Chandra 1988
Publikováno v:
Pharmacologytoxicology. 78(3)
Effects of Ca(2+)-channel modulators were examined in human, bovine and murine parathyroid tissue. In 0.5 mM external Ca2+, 100 microM verapamil inhibited parathyroid hormone release, stimulated uptake and efflux of 45Ca and raised cytoplasmic Ca2+ c
Publikováno v:
Pharmacologytoxicology. 78(3)
The protective effects of Ca2+ channel blockers against the toxicity of methyl mercury were examined by both in vivo and in vitro experiments. In the in vivo study we first examined the effects of the Ca2+ channel blockers (20 mg/ kg/day), flunarizin
Publikováno v:
Pharmacologytoxicology. 77(1)
Diclofenac (0.5 -2 mM) dose- and time-dependently reduces the viability of isolated hepatocytes. This effect cannot be counteracted by the calcium channel blockers diltiazem (0.05-0.1 mM) and verapamil (0.05-0.5 mM), the calmodulin antagonist calmida
Publikováno v:
Pharmacologytoxicology. 75(5)
Potassium accumulation in rat heart after alpha-1-adrenoceptor stimulation has previously been reported from indirect measurements. Here we present data on intracellular potassium content measured directly in the heart. Isolated rat hearts perfused i
Publikováno v:
Pharmacologytoxicology. 73(1)
Experimental evidence suggests that potassium channel openers play an important role in convulsions. In this study, the anticonvulsant activity of BRL 38227, a new potassium channel opener against digoxin-induced convulsions, is reported. Intraventri
Publikováno v:
Knudsen, T, Bertelsen, H & Johansen, T 1992, ' Ouabain enhancement of compound 48/80 induced histamine secretion from rat peritoneal mast cells: dependence on extracellular sodium ', Pharmacology and Toxicology, vol. 70, no. 6 Pt 1, pp. 412-8 . https://doi.org/10.1111/j.1600-0773.1992.tb00499.x
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Purified populations of rat peritoneal mast cells were used to study the effect of ouabain on compound 48/80-induced histamine secretion and on 86Rb+ uptake. 86Rb+ was used as a tracer for extracellular K+. The calculated value of the ouabain-sensiti