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Publikováno v:
Pharmacology Biochemistry and Behavior. 200:173079
Long-lasting pain can induce depression, which seriously affects life quality of the patients, but little is known about the underlying mechanism. Chronic neuropathic pain can modulate DNA methylation in target genes related to neuroplasticity and mo
Autor:
Jennifer E. Murray, Brady M. Thompson, Y. Wendy Huynh, Scott T. Barrett, David A. Kwan, Rick A. Bevins
Publikováno v:
Pharmacol Biochem Behav
Nicotine and varenicline (Chantix®; the leading non-nicotine cessation pharmacotherapy) can come to control appetitive behaviors such as goal-tracking. We tested rats (N = 48) in a drug-discriminated goal-tracking (DGT) task where each rat received
Publikováno v:
Pharmacology Biochemistry and Behavior. 199:173038
Animal models of acquisition have been vital in shaping our understanding of vulnerability factors that influence susceptibility to drugs of abuse. Decades of research substantiates a number of biological, environmental, and behavioral factors that p
Publikováno v:
Pharmacology Biochemistry and Behavior. 199:173064
Risperidone use in children and adolescents is associated with the development of metabolic disorders including increased accumulation of body fat, dyslipidemia, and glucose and insulin metabolism dysregulation. As pharmacological interventions are o
Publikováno v:
Pharmacology Biochemistry and Behavior. 199:173040
Female sexual dysfunction is both a symptom of depression and exacerbated by treatments for depression. Ketamine, a novel treatment for depression, has been shown to enhance, whereas fluoxetine has been shown to impair sexual motivation. Sexual exper
Publikováno v:
Pharmacol Biochem Behav
Over the last two decades the United States has experienced a significant increase in the medical and non-medical use of opioid drugs, resulting in record numbers of opioid-related overdoses and deaths. There was an initial increase in non-medical us
Publikováno v:
Pharmacology Biochemistry and Behavior. 198:173035
Considerable evidence indicates that adenosine and dopamine systems interact in the regulation of basal ganglia function. Nonselective adenosine antagonists such as the methylxanthine caffeine as well as selective adenosine A2A antagonists have been
Publikováno v:
Pharmacology Biochemistry and Behavior. 198:173033
Instrumental actions are initially goal-directed and driven by their associated outcome. However, with repeated experience habitual actions develop which are automated and efficient, as they are instead driven by antecedent stimuli. Dopamine is thoug
Autor:
Mary Jeanne Kreek, Kyle A. Windisch
Publikováno v:
Pharmacology Biochemistry and Behavior. 198:173022
Adolescence is a critical period of development with robust behavioral, morphological, hormonal, and neurochemical changes including changes in brain regions implicated in the reinforcing effects of drugs such as opioids. Here we examine the preclini
Publikováno v:
Pharmacology Biochemistry and Behavior. 197:173012
The role of pallidal serotonergic terminals in the development of L-Dopa-induced dyskinesias (LIDs) in Parkinson's disease (PD) has been recently highlighted correlating pallidal serotonin transporter (SERT) expression levels with dyskinesias severit