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Publikováno v:
Pharmacology Biochemistry and Behavior. 152:90-96
Preclinical psychopharmacology research needs novel behavioral indices and improved animal models for both sexes. The forced swim test (FST) is the most popular test for screening antidepressant potential. Sex differences in FST behaviors, such as im
Autor:
Mark W. Kimpel, Howard J. Edenberg, Jeanette N. McClintick, Lucinda G. Carr, Wendy N. Strother, Tiebing Liang, Zachary A. Rodd, William J. McBride, Richard L. Bell
Publikováno v:
Pharmacology Biochemistry and Behavior. 89:481-498
The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression in the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant parad
Autor:
C.J. Peter Eriksson, Tiina Koivisto
Publikováno v:
Pharmacology Biochemistry and Behavior. 56:441-446
Alcohol-preferring AA and alcohol-avoiding ANA rat lines differ in their acetaldehyde metabolism and this has been suggested to be one reason for their different ethanol drinking behavior. To study whether acetaldehyde accumulation is indeed associat
Publikováno v:
Pharmacology Biochemistry and Behavior. 53:839-842
We studied the effect of the K+ channel opener cromakalim, which exhibits antihypertensive properties, on food intake in rats. Intraperitoneally injected cromakalim induced a dose-dependent (0.1, 0.5, and 1.0 mg/kg body wt.) reduction in food intake,
Publikováno v:
Pharmacology Biochemistry and Behavior. 53:33-40
Both the 5-HT2 antagonist, FG5606 (amperozide), and the mixed 5-HT1 agonist/5-HT2 antagonist, FG5893, attenuate significantly the volitional intake of alcohol in the cyanamide treated rat. The purpose of the present study was to investigate the effec
Publikováno v:
Pharmacology Biochemistry and Behavior. 52:29-34
The role of central monoamines in the genetically determined influences on voluntary ethanol consumption were examined by studying the extracellular levels of monoamines in the nucleus accumbens of the alcohol-preferring AA (Alko Alcohol) and alcohol
Publikováno v:
Pharmacology Biochemistry and Behavior. 49:759-762
In the present study, we investigated whether functional adaptational changes in the serotonergic neurotransmitter mechanisms regulating food intake following long-term lithium treatment in Fawn-Hooded rats (a rat strain suggested to represent a gene
Autor:
Danny R. Grady, Amir H. Rezvani
Publikováno v:
Pharmacology Biochemistry and Behavior. 48:105-110
The high preference for alcohol intake observed in Fawn-Hooded rats has been attributed to the central serotonin (5-HT) dysfunction in this strain. To further characterize the involvement of 5-HT in alcohol-seeking behavior in Fawn-Hooded rats, the e
Publikováno v:
Pharmacology Biochemistry and Behavior. 47:795-802
Initial self-administration of high doses of EtOH is shown to be associated in some inbred rat strains with the eventual development of a low preference for EtOH, presumably as a consequence of taste aversion learning occuring during initial intake.
Autor:
A.B. Keith, A. Sahgal
Publikováno v:
Pharmacology Biochemistry and Behavior. 45:995-1001
Rats were trained on a delayed nonmatching to position task, divided into four groups and given the following lesions: (a) SHAM (vehicle injection into nucleus basilis magnocellularis (NBM) and raphe nuclei (RN), (b) RN (5,7-dihydroxytryptamine lesio