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Publikováno v:
Pharmacology Biochemistry and Behavior. 179:89-97
The Gateway Hypothesis is based on epidemiological data and states there is a progression of drug use from use of a softer drug (e.g., nicotine) to use of a harder drug (e.g., morphine). It has been suggested that this sequence is causal and is relev
Autor:
David E. Komatsu, Connor Martin, Panayotis K. Thanos, Daniel Popoola, Abisha Vijayashanthar, Michael Hadjiargyrou, Courtney Lowinger, Dennis Fricke, Dimitris Koutsomitis
Publikováno v:
Pharmacology Biochemistry and Behavior. 172:22-32
Chronic oral methylphenidate (MP) exposure in rats is associated with numerous developmental and behavioral consequences. The present study investigated the persistence of the effects of chronic oral MP exposure after abstinence from MP use. Male and
Publikováno v:
Pharmacology Biochemistry and Behavior. 157:24-34
Adolescence is a phase of development during which many physiological and behavioral changes occur, including increased novelty seeking and risk taking. In humans, this is reflected in experimentation with drugs. Research demonstrates that drug use t
Publikováno v:
Pharmacology Biochemistry and Behavior. :68-75
Drugs of abuse, as cocaine or amphetamine, induce locomotor sensitization during infancy and adulthood of the rat. This effect during the preweanling period is observed only after a short interval of time between training and testing. We recently rep
Publikováno v:
Pharmacology Biochemistry and Behavior. 199:173038
Animal models of acquisition have been vital in shaping our understanding of vulnerability factors that influence susceptibility to drugs of abuse. Decades of research substantiates a number of biological, environmental, and behavioral factors that p
Publikováno v:
Pharmacology Biochemistry and Behavior. 199:173064
Risperidone use in children and adolescents is associated with the development of metabolic disorders including increased accumulation of body fat, dyslipidemia, and glucose and insulin metabolism dysregulation. As pharmacological interventions are o
Publikováno v:
Pharmacology Biochemistry and Behavior. 199:173040
Female sexual dysfunction is both a symptom of depression and exacerbated by treatments for depression. Ketamine, a novel treatment for depression, has been shown to enhance, whereas fluoxetine has been shown to impair sexual motivation. Sexual exper
Autor:
Mariam Melkumyan, Briana J. Hempel, Madeline E. Crissman, Anthony L. Riley, Jacob Madar, Chloe A. Winston
Publikováno v:
Pharmacology Biochemistry and Behavior. 197:173001
Exposure to environmental stimuli in one generation can produce altered behavioral and neurobiological phenotypes in descendants. Recent work has shown that parental exposure to cannabinoids alters the rewarding properties of other abused drugs in th
Publikováno v:
Pharmacol Biochem Behav
Cigarette smoking and resultant nicotine dependence remain major public health problems. Most smokers begin before the age of 18, yet preclinical models have insufficiently characterized the development of nicotine dependence in adolescence. To categ
Autor:
Alonso Fernández-Guasti, Nallely García-Cárdenas, Blanca Nelly Gómez-Quintanar, Sandra Olvera-Hernández
Publikováno v:
Pharmacology Biochemistry and Behavior. 135:128-135
Homosexual men show a 2-4 higher risk to suffer anxiety in comparison with heterosexuals. It is unknown if biological factors collaborate to increase such incidence. Fluoxetine produces differential brain activation in homosexuals as compared with he