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Publikováno v:
Pharmacology Biochemistry and Behavior. 179:27-33
Mecamylamine is a non-competitive nicotinic acetylcholine receptor (nAChR) antagonist that has been prescribed for hypertension and as an off-label smoking cessation aid. Here, we examined pharmacological mechanisms underlying the interoceptive effec
Publikováno v:
Pharmacology Biochemistry and Behavior. 175:1-9
Responsiveness to ethanol (EtOH) differs as a function of age. Adolescent rodents are less sensitive than adults to the sedative effects of EtOH, whereas they show enhanced sensitivity to EtOH-induced social facilitation. Late aging is associated wit
Autor:
Laura López-Cruz, Mercè Correa, Marta Pardo, Noemí SanMiguel, John D. Salamone, Carla Carratalá-Ros
Publikováno v:
Pharmacology Biochemistry and Behavior. 169:27-34
Motivated behavior is characterized by activation and high work output. Nucleus accumbens (Nacb) modulates behavioral activation and effort-based decision-making. Caffeine is widely consumed because of its energizing properties. This methylxanthine i
Autor:
Ana Elisa da Silva Ribeiro, Danielly Gonçalves Sombra Lima, Keicy Parente de Siqueira, Monalisa Ribeiro Silva, Roberta Oliveira da Costa, Daniel Luna Lucetti, Kelly Rose Tavares Neves, Elaine Cristina Pereira Lucetti, Jonathan Almeida Moura, Gabriel Cabral Alencar dos Santos, Lucas Leimig Telles Parente, Alyne Oliveira Correia, Glauce Socorro de Barros Viana
Publikováno v:
Pharmacology Biochemistry and Behavior. 167:17-28
Valproic acid (VA) is an antiepileptic that is also used for the treatment of bipolar disorders. The objective was to evaluate the neuroprotective effects of VA on a brain ischemia model. The groups of male Wistar rats were: SO (sham-operated), ische
Publikováno v:
Pharmacology Biochemistry and Behavior. 165:45-55
The ability of smoking to reduce body weight serves as motivation for continued smoking. It is unclear to what extent non-nicotine constituents in cigarettes are contributing to the weight-reducing effect of smoking. The purpose of the current study
Publikováno v:
Pharmacology Biochemistry and Behavior. 163:66-73
The aim of the present study was to examine cross state-dependent learning between ACPA (a selective cannabinoid CB1 receptor agonist) and muscimol (a selective GABAA receptor agonist) in the step-down inhibitory avoidance learning task. The dorsal h
Publikováno v:
Pharmacology Biochemistry and Behavior. 156:48-55
Background α-Pyrrolidinopentiophenone (α-PVP) has been reported to be rewarding in a variety of pre-clinical models. Given that a number of drugs of abuse have both rewarding and aversive effects, the balance of which influences addiction potential
Autor:
Vanessa Angonesi Zborowski, Gilson Zeni, Carla Elena Sartori Oliveira, Marcel Henrique Marcondes Sari, Cristina W. Nogueira, Paulo Cesar Oliveira Araujo
Publikováno v:
Pharmacology Biochemistry and Behavior. 154:31-38
Major depressive disorder is the most severe and debilitating disease among psychiatric illnesses. The abrupt interruption of antidepressant treatment may lead to a complex physiological and neuropsychiatric syndrome. The organoselenium compound (MeO
Publikováno v:
Pharmacology Biochemistry and Behavior. :39-47
Curcumin, a natural polyphenolic compound extracted from rhizomes of Curcuma longa (turmeric), a plant in the ginger family (Zingiberaceae) has been used worldwide and extensively in Southeast Asia. Curcumin exhibited numerous biological and pharmaco
Publikováno v:
Pharmacology Biochemistry and Behavior. :147-152
The goal of the present work was to characterise the effects of selegiline on the rat sleep pattern. Furthermore, for comparative purposes, the pharmacokinetics of selegiline and its metabolites in brain and plasma were investigated, and microdialysi