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Publikováno v:
Pharmacol Biochem Behav
Over the past two decades, opioid abuse has risen especially among women. In both sexes hippocampal neural circuits involved in associative memory formation and encoding of motivational incentives are critically important in the transition from initi
Autor:
Kenji Hashimoto, Yukihiko Shirayama, Tomihisa Niitsu, Nobuhisa Kanahara, Yuki Hirose, Yasunori Oda, Hiroshi Kimura, Masaomi Iyo, Kouhei Yoshino, Makoto Kimura
Publikováno v:
Pharmacology, biochemistry, and behavior. 211
Background The excessive blockade of dopamine D2 receptors (DRD2s) with long-term antipsychotic treatment is known to induce a dopamine supersensitivity state (DSS). The mechanism of DSS is speculated to be a compensatory up-regulation of DRD2s, but
Publikováno v:
Pharmacology, biochemistry, and behavior. 209
Neuronal adaptations involving dopaminergic, glutamatergic, and serotonergic neurotransmitter systems are responsible for behavioral sensitization. Because of common underlying mechanisms, cross-sensitization between compounds of different drug class
Publikováno v:
Pharmacology, biochemistry, and behavior. 211
Alcohol abuse is a widespread cause of aggressive and impulsive behaviors that impact the users as well as their entourage. However, only a few medications are effective. Recently, cannabidiol has been reported to improve mood disorders and recovery
Autor:
Andrew C. Harris
Publikováno v:
Pharmacology, biochemistry, and behavior. 205
Relief from increases in anxiety during nicotine withdrawal contributes to tobacco addiction. While a variety of anxiogenic stimuli elicit avoidance of the center of an open field (thigmotaxis) in rodents, effects of nicotine withdrawal on thigmotaxi
Publikováno v:
Pharmacology, biochemistry, and behavior. 205
Depression is a psychiatric disorder with several comorbidities that has a complicated pathophysiology. Multiple mechanisms such as abnormal hypothalamic-pituitary adrenal (HPA) axis activity, neurotransmission (namely serotonin), and immune-inflamma
Publikováno v:
Pharmacol Biochem Behav
Advances in drug vapor exposure systems have enabled evaluation of Δ-9-tetrahydrocannabinol (THC) vapor effects in laboratory animals. The purpose of this study was to 1) establish a range of parameters of THC vapor exposure in rats sufficient to pr
Publikováno v:
Pharmacology, biochemistry, and behavior. 203
Background Disorders characterized by dysfunction of glucose metabolism are often comorbid with depression. The current study investigated whether a hypoglycemic state caused by 2-deoxy- d -glucose (2-DG) can result in anhedonic behaviors responsive
Sex differences in the discriminative stimulus characteristics of a morphine occasion setter in rats
Publikováno v:
Pharmacology, biochemistry, and behavior. 205
The current study investigated whether the stimulus effects of morphine can function as a positive and negative feature in a Pavlovian occasion setting drug discrimination preparation in male and female rats. Sprague-Dawley rats were assigned to a fe
Autor:
Jeffrey M. Witkin, Rok Cerne, Jodi L. Smith, Amy Hauck Newman, Frank C. Tortella, Sari Izenwasser
Publikováno v:
Pharmacol Biochem Behav
Interest in developing minimal side-effect NMDA receptor antagonists for neurological and psychiatric disorders has been energized by the recent introduction of esketamine into clinical practice for treatment-resistant depression. Structural analogs