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Publikováno v:
Pharmacology, biochemistry, and behavior. 211
Alcohol abuse is a widespread cause of aggressive and impulsive behaviors that impact the users as well as their entourage. However, only a few medications are effective. Recently, cannabidiol has been reported to improve mood disorders and recovery
Publikováno v:
Pharmacol Biochem Behav
Advances in drug vapor exposure systems have enabled evaluation of Δ-9-tetrahydrocannabinol (THC) vapor effects in laboratory animals. The purpose of this study was to 1) establish a range of parameters of THC vapor exposure in rats sufficient to pr
Publikováno v:
Pharmacology, biochemistry, and behavior. 203
Background Disorders characterized by dysfunction of glucose metabolism are often comorbid with depression. The current study investigated whether a hypoglycemic state caused by 2-deoxy- d -glucose (2-DG) can result in anhedonic behaviors responsive
Publikováno v:
Pharmacol Biochem Behav
Cue-induced drug craving and seeking progressively increases during abstinence. This "incubation of drug craving" phenomenon has been observed in both laboratory animals and humans. Preclinical studies identified several neural mechanisms underlying
Autor:
Fay A. Guarraci, Elizabeth L. Henneman, Larry W. Clemons, Lourdes K. Davis, Maryam Ali, Shannon E. Odell, Devon Lucero, Chantal M.F. Gonzalez, Sarah H. Meerts
Publikováno v:
Pharmacology, biochemistry, and behavior. 199
The present study characterized the effects of weekly ketamine injections on sexual behavior and anxiety in female and male rats, using a dosing protocol that mimics human therapeutic treatment for depression. In Experiment 1A, ketamine (10 mg/kg, i.
Publikováno v:
Pharmacology, biochemistry, and behavior. 199
Ketamine, a multimodal dissociative anesthetic drug, is widely used to treat various conditions including acute pain and treatment-resistant depression. We previously reported that subanesthetic doses of intravenous (i.v.) ketamine produced transient
Autor:
Samira S. Valvassori, Gustavo C. Dal-Pont, Wilson R. Resende, Susannah J. Tye, Fernanda F. Gava, Roger B. Varela, João Quevedo
Publikováno v:
Pharmacology, biochemistry, and behavior. 193
Background The etiology of bipolar disorder (BD) is multifactorial, involving both environmental and genetic factors. Current pharmacological treatment is associated with several side effects, which are the main reason patients discontinue treatment.
Autor:
Jorge Juárez, Rocio Heyer-Osorno
Publikováno v:
Pharmacology, biochemistry, and behavior. 194
Rats exposed prenatally to alcohol show a reduction in the spontaneous activity of dopaminergic neurons of the ventral tegmental area (VTA), as well as greater impulsive behavior and motor activity, behavioral alterations that have been related to do
Publikováno v:
Pharmacology, biochemistry, and behavior. 187
Gender- and age-dependent effects on the severity of morphine dependence are still controversial. The aim of this study was to investigate the effects of age and sex on the severity of physical and psychological dependence in morphine-dependent rats.
Autor:
Manuel Ramírez-Sánchez, Ana Belén Segarra, Isabel Prieto, Juan de Dios Luna, Marc de Gasparo, Raquel Duran, Francisco Vives, Inmaculada Banegas
Publikováno v:
Pharmacology, biochemistry, and behavior. 182
Aminopeptidase A is responsible for the hydrolysis of angiotensin II and cholecystokinin. By measuring its activity we obtain a reflection of the functional status of its endogenous substrates. Dopamine coexists with these neuropeptides in striatum a