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Autor:
Kenji Hashimoto, Yukihiko Shirayama, Tomihisa Niitsu, Nobuhisa Kanahara, Yuki Hirose, Yasunori Oda, Hiroshi Kimura, Masaomi Iyo, Kouhei Yoshino, Makoto Kimura
Publikováno v:
Pharmacology, biochemistry, and behavior. 211
Background The excessive blockade of dopamine D2 receptors (DRD2s) with long-term antipsychotic treatment is known to induce a dopamine supersensitivity state (DSS). The mechanism of DSS is speculated to be a compensatory up-regulation of DRD2s, but
Autor:
Caroline Smith, Leandro F. Vendruscolo, Michael A. Arends, Sophie K. Elvig, M. Adrienne McGinn, George F. Koob
Publikováno v:
Pharmacol Biochem Behav
Alcohol tolerance refers to a lower effect of alcohol with repeated exposure. Although alcohol tolerance has been historically included in diagnostic manuals as one of the key criteria for a diagnosis of alcohol use disorder (AUD), understanding its
Publikováno v:
Pharmacol Biochem Behav
Identifying novel constituents that contribute to tobacco addiction is essential for developing more effective treatments and informing FDA regulation of tobacco products. While preclinical data indicate that monoamine oxidase (MAO) inhibitors can ha
Autor:
Olivia Geary, Abrianna Mihalkovic, Panayotis K. Thanos, Rylee Haffey, Nabeel Rahman, John Hamilton
Publikováno v:
Pharmacology, biochemistry, and behavior. 196
Exercise programs have shown great potential for both the prevention and treatment of substance use disorder (SUD). As exercise has been shown to have potent effects on physical and psychological health, it is reasonable to examine the mechanism of h
Publikováno v:
Pharmacology, biochemistry, and behavior. 181
Anxiety is a common symptom of schizophrenia. Ketamine, which acts as a noncompetitive antagonist of glutamatergic NMDA receptors by binding to the phencyclidine site, may induce schizophrenia-like symptoms and promote anxiogenic-like behaviour. The
Publikováno v:
Pharmacol Biochem Behav
Impairment in glutamate neurotransmission mediates the development of dependence upon nicotine (NIC) and ethanol (EtOH). Previous work indicates that continuous access to EtOH or phasic exposure to NIC reduces expression of the glutamate transporter-
Autor:
Jaesuk Yun, Hyung-Soo Kim, Hye Jin Cha, Young-Hoon Kim, Kwang-Wook Lee, Jang-Hyeon Eom, Kyoungmoon Han, Jisoon Shin
Publikováno v:
Pharmacology, biochemistry, and behavior. 149
Although 5-(2-aminopropyl)benzofuran (5-APB) and 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (phenazepam) are being used as recreational drugs, research on their dependence liability or mechanisms of action is lacking. The prese
Publikováno v:
Pharmacology, biochemistry, and behavior. 138
Nicotine is a parasympathomimetic alkaloid present in tobacco which can induce hyperlipidemia and has a direct effect on neural functions. Statins, competitive inhibitors of 3-hydroxymethyl-3-glutaryl-coenzyme-A reductase, are cholesterol lowering dr
Autor:
Emilio L. Streck, Jéssica Lopes-Borges, Paula T. Tonin, João Quevedo, Roger B. Varela, Júlia S. Vieira, Cinara L. Gonçalves, Samira S. Valvassori
Publikováno v:
Pharmacology, biochemistry, and behavior. 128
Studies have revealed alterations in mitochondrial complexes in the brains of bipolar patients. However, few studies have examined changes in the enzymes of the tricarboxylic acid cycle. Several preclinical studies have suggested that histone deacety
Autor:
Emer S. Ferro, Fabio C. Gozzo, Manoela V. Fogaça, Francisco Silveira Guimarães, Vanessa Rioli, Camila Squarzoni Dale, Andreza Buzolin Sonego
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Hemopressin (PVNFKFLSH; HP) is an orally active peptide derived from rat hemoglobin α-chain that could act as an inverse agonist at cannabinoid type 1 receptors (CB 1 ). Here, we aim to investigate possible behavioral effects of HP in male Wistar ra