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Autor:
Mohammed EL-dosoky, Hussein M. Ismail, Mohamed K. El-Kherbetawy, Sally Abed, Khalid Mohamad Morsy Ibraheem, Ahmed M. Abdelrady, Eman A. Toraih, Walid Kamal Abdelbasset, Manal S. Fawzy, Rehab M. Lashine, Noha E. Farag, Sawsan A. Zaitone
Publikováno v:
Pharmaceuticals, Vol 14, Iss 597, p 597 (2021)
Pharmaceuticals
Volume 14
Issue 7
Pharmaceuticals
Volume 14
Issue 7
Macrolides were reported to have cardiotoxic effects presented mainly by electrocardiogram (ECG) changes with increased risk in cardiac patients. We aimed to determine the impact of three macrolides, azithromycin, clarithromycin and erythromycin, on
Publikováno v:
Pharmaceuticals, Vol 13, Iss 347, p 347 (2020)
Pharmaceuticals
Pharmaceuticals
The kallikrein–kinin system (KKS) is proposed to act as a counter regulatory system against the vasopressor hormonal systems such as the renin-angiotensin system (RAS), aldosterone, and catecholamines. Evidence exists that supports the idea that th
Autor:
Kacper Maksymilian Mil, Mateusz Maciejczyk, Małgorzata Ewa Gryciuk, Cezary Pawlukianiec, Małgorzata Żendzian-Piotrowska, Anna Zalewska
Publikováno v:
Pharmaceuticals, Vol 13, Iss 240, p 240 (2020)
Pharmaceuticals
Volume 13
Issue 9
Pharmaceuticals
Volume 13
Issue 9
Meloxicam is a non-steroidal anti-inflammatory drug, which has a preferential inhibitory effect to cyclooxyganase-2 (COX-2). Although the drug inhibits prostaglandin synthesis, the exact mechanism of meloxicam is still unknown. This is the first stud
Autor:
Maria Claudia dos Santos Luciano, Claudio Silva Teixeira, Joabe Lima Araújo, João Antônio Leal de Miranda, Ícaro Gusmão Pinto Vieira, Conceição da Silva Martins, João Erivan Façanha Barreto, Francisco Orlando Rafael Freitas, Gerly Anne de Castro Brito, Ariel Gustavo Scafuri, Maria Elenir Nobre Pinho Ribeiro, Gilberto Santos Cerqueira, Helder Bindá Pimenta, Paulo Vitor de Souza Pimentel, Matheus da Silva Campelo, Nágila M.P.S. Ricardo, Maria Lucianny Lima Barbosa, Jefferson Almeida Rocha, Lázaro de Sousa Fideles
Publikováno v:
Pharmaceuticals, Vol 13, Iss 1, p 10 (2020)
Pharmaceuticals
Volume 13
Issue 1
Pharmaceuticals
Volume 13
Issue 1
Intestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), a chemotherapeutic agent used for cancer treatment. Troxerutin (TRX), a semi-synthetic flavonoid extracted from Dimorphandra gardneriana, has been reported as a pote
Publikováno v:
Pharmaceuticals, Vol 14, Iss 380, p 380 (2021)
Pharmaceuticals; Volume 14; Issue 4; Pages: 380
Pharmaceuticals
Pharmaceuticals; Volume 14; Issue 4; Pages: 380
Pharmaceuticals
The risk of developing epilepsy is strongly linked to peripheral inflammatory disorders in humans. High-mobility group box protein 1 (HMGB1) has the most focus for being a suspect in this scenario. The current study aimed to detect the celecoxib effe
Autor:
Joanna Sikora, Kristiina M. Huttunen, Marlena Broncel, Magdalena Markowicz-Piasecka, Adrianna Sadkowska
Publikováno v:
Pharmaceuticals, Vol 13, Iss 323, p 323 (2020)
Pharmaceuticals
Volume 13
Issue 10
Pharmaceuticals
Volume 13
Issue 10
Metformin, one of the most frequently prescribed oral anti-diabetic drugs, is characterized by multidirectional activity, including lipid lowering, cardio-protective and anti-inflammatory properties. This study presents synthesis and stability studie
Autor:
Shu T. Kung, Sreedhar Chamala, Ramesh B. Batchu, Scott A. Gruber, Christopher S. Bryant, Udaya S. Puttagunta, Oksana V. Gruzdyn, Ramana S. Sanka, Aamer Qazi, Sanjeev Kumar, Donald W. Weaver
Publikováno v:
Pharmaceuticals; Volume 7; Issue 1; Pages: 46-57
Pharmaceuticals, Vol 7, Iss 1, Pp 46-57 (2014)
Pharmaceuticals
Pharmaceuticals, Vol 7, Iss 1, Pp 46-57 (2014)
Pharmaceuticals
Recent observations suggest a lower incidence of malignancies in patients infected with HIV during treatment with Highly Active Anti-Retroviral Therapy (HAART) utilizing protease inhibitors. We investigated the effects of ritonavir, a FDA approved HI
Autor:
Jan Jakubík, Esam E. El-Fakahany
Publikováno v:
Pharmaceuticals
Pharmaceuticals, Vol 3, Iss 9, Pp 2838-2860 (2010)
Pharmaceuticals, Vol 3, Iss 9, Pp 2838-2860 (2010)
An allosteric modulator is a ligand that binds to an allosteric site on the receptor and changes receptor conformation to produce increase (positive cooperativity) or decrease (negative cooperativity) in the binding or action of an orthosteric agonis
Publikováno v:
Pharmaceuticals
Pharmaceuticals, Vol 3, Iss 7, Pp 2238-2247 (2010)
Pharmaceuticals, Vol 3, Iss 7, Pp 2238-2247 (2010)
The incidence of prostate cancer increases with age and because of its high prevalence this disease has become a major public health concern. Despite advances in our understanding of the biological mechanisms responsible for the development of this c
Publikováno v:
Pharmaceuticals, Vol 3, Iss 5, Pp 1594-1613 (2010)
Pharmaceuticals
Pharmaceuticals
Aspirin (acetylsalicylic acid) is a well-known nonsteroidal anti-inflammatory drug (NSAID) that has long been used as an anti-pyretic and analgesic drug. Recently, much attention has been paid to the chemopreventive and apoptosis-inducing effects of