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Autor:
Philipp Gabriel, Aida Salameh, Beate Rassler, Christian Bölter, Peter Appelt, Nicole Fiedler, Katrin Schierle
Publikováno v:
Pflugers Archiv
Acute normobaric hypoxia may induce pulmonary injury with edema (PE) and inflammation. Hypoxia is accompanied by sympathetic activation. As both acute hypoxia and high plasma catecholamine levels may elicit PE, we had originally expected that adrener
Publikováno v:
Pflugers Archiv
The purpose of this study was to investigate the effect of lithium on glucose disposal in a high-fat diet-induced type 2 diabetes mellitus (T2DM) and streptozotocin-induced type 1 diabetes mellitus (T1DM) animal model along with low-volume exercise a
Publikováno v:
Pflugers Archiv
Earlier evidence from studies of rat hypertension models undermines the widespread view that the rate of renal medullary blood flow (MBF) is critical in control of arterial pressure (MAP). Here, we examined the role of MBF in rats that were normotens
Autor:
Muneyoshi Okada, Kiko Hori, Shoshiro Okada, Hideyuki Yamawaki, Kengo Matsumoto, Satoshi Kameshima, Atsunori Yamamoto, Naoko Yamaguchi
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 472:673-681
Chemerin is an adipocytokine involved in inflammation and lipid metabolism via G protein-coupled receptor, chemokine-like receptor (CMKLR)1. Since the important nuclei regulating pressure (BP) exist in the brain, we examined the effects of acute intr
Publikováno v:
Pflugers Arch
Connexin43 is an important modulator of many signaling pathways in bone. β-Catenin, a key regulator of the osteoblast differentiation and function, is among the pathways downstream of connexin43-dependent intercellular communication. There are strik
Autor:
Charlotte Mehlin Sorensen, Jens Chr. Brings Jacobsen, Rasmus Bo Sørensen, Preben Graae Sørensen, Bjørn Olav Hald
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 471:271-283
Resistance vessels regulate blood flow by continuously adjusting activity of the wall smooth muscle cells. These cells integrate a variety of stimuli from blood, endothelium, autonomic nerves, and surrounding tissues. Each stimulus elicits an intrace
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 470:1391-1403
Angiotensin II preconditioning (APC) involves an angiotensin II type 1 receptor (AT1-R)-dependent translocation of PKCe and survival kinases to the mitochondria leading to cardioprotection after ischemia-reperfusion (IR). However, the role that mitoc
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 470:883-895
Elevated plasma levels of the hormone vasopressin have been implicated in the pathogenesis of some forms of hypertension. Hypothalamic paraventricular and supraoptic nuclei neurons regulate vasopressin secretion into the circulation. Vasopressin neur
Autor:
Martin Diener, Sandra Bader
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 470:669-679
Acetylcholine is not only a neurotransmitter but is also produced by several non-neuronal cell types with barrier or defence function. One of the non-neuronal tissues with expression of the key enzyme for production of acetylcholine, the choline acet
Autor:
Carolina Demarchi Munhoz, Ana Paula Cremasco Takano, Nathalia Senger, Maria Luiza Morais Barreto-Chaves
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 470:549-558
We have previously demonstrated that calcium-binding protein S100A8 and myeloid differentiation factor-88 (MyD88) are important mediators of nuclear transcription factor kappa-B (NF-κB) activation in cardiomyocytes and that signalling molecules are