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Publikováno v:
Pflugers Archiv : European journal of physiology. 472(3)
We investigated the direct effects of prolonged exposure to advanced glycation end-products (AGEs) on noradrenaline-induced contraction of rat carotid artery smooth muscle. Noradrenaline-induced contraction of endothelium-denuded carotid artery rings
Autor:
Sandra Bader, Stefanie Gerbig, Gerhard Breves, Andreas Schwiertz, Bernhard Spengler, Martin Diener
Publikováno v:
Pflugers Archiv : European journal of physiology. 471(4)
Acetylcholine and atypical esters of choline such as propionyl- and butyrylcholine are produced by the colonic epithelium and are released when epithelial receptors for short-chain fatty acids (SCFA) are stimulated by propionate. It is assumed that t
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
The classic model of fever induction is based on the administration of lipopolysaccharide (LPS) from Gram-negative bacteria in experimental animals. LPS-induced fever results in the synthesis/release of many mediators that assemble an LPS-fever casca
Publikováno v:
Pflugers Archiv : European journal of physiology. 467(11)
Increased vascular smooth muscle cell (VSMC) contraction is an early and critical contributor to the pathogenesis of vascular dysfunction in diabetes; however, knowledge regarding the underlying mechanisms is scarce. Toll-like receptor 2 (TLR2), a we
Publikováno v:
Pflugers Archiv : European journal of physiology. 466(7)
The goal of this study was to determine the molecular identity of a small-conductance (~5-pS) background K(+) channel expressed in trigeminal ganglion (TG) neurons. We tested the hypothesis that the 5-pS channel is a K2P channel by comparing the phar
Publikováno v:
Pflugers Archiv : European journal of physiology. 465(7)
Klotho constitutes the receptor for fibroblast growth factor 23 (FGF23). However, the effects of FGF23 on renal and circulating klotho are not well-known. In vivo experiments were performed to assess the effects of FGF23 (10 μg/kg), parathyroid horm
Autor:
Jorge Gonzalez Casanova, Aida Salameh, Sandy von Salisch, Ingo Daehnert, Friedrich-Wilhelm Mohr, Daniel Apel, Stefan Dhein
Publikováno v:
Pflugers Archiv : European journal of physiology. 464(5)
Cyclic mechanical stretch (CMS) and angiotensin II (ATII) play an important role in cardiac remodelling. Thus, we aimed to examine how ATII affects CMS-induced changes in localisation and expression of the gap junction protein connexin43 (Cx43). Neon
Autor:
Yevgenij Yanovsky, Stephan R. Schubring, Helmut L. Haas, Olga A. Sergeeva, Günter Gisselmann, Hanns Hatt, Wiebke Fleischer, Uwe Rudolph, Hermann Lübbert, Xin-Ran Zhu
Publikováno v:
Pflugers Archiv : European journal of physiology. 463(1)
The histaminergic neurons of the posterior hypothalamus (tuberomamillary nucleus-TMN) control wakefulness, and their silencing through activation of GABA(A) receptors (GABA(A)R) induces sleep and is thought to mediate sedation under propofol anaesthe
Autor:
Kumiko Goto, Miwa Misawa, Ayako Nishimura, Yuko Nishizawa, Motohiko Hanazaki, Hiroyasu Sakai, Yoshihiko Chiba
Publikováno v:
Pflugers Archiv : European journal of physiology. 460(3)
Angiotensin II (Ang II) might be an important mediator in the pathogenesis of bronchial asthma, although the mechanisms of airway hyperresponsiveness caused by Ang II are not yet clear. Whether p42/44 ERK contributes to the Ang II-elicited bronchial
Publikováno v:
Pflugers Archiv : European journal of physiology. 458(3)
Non-adapting superior cervical ganglion (SCG) neurones with a clustering activity and sub-threshold membrane potential oscillations were occasionally recorded, suggesting the presence of a persistent sodium current (I NaP). The perforated-patch techn