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Ryanodine receptors in peritoneal mast cells: possible role in the modulation of exocytotic activity
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 447:377-386
Previous studies have shown that ryanodine in low concentrations and caffeine increase intracellular [Ca(2+)] in the absence of external Ca(2+), suggesting Ca(2+) release from intracellular stores through ryanodine receptors (RyR). In the present stu
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 444:476-483
In rat distal colon, aldosterone has little effect on Na(+) channel (ENaC) alpha-subunit levels but increases the expression of the beta- and gamma-subunits and stimulates electrogenic Na(+) transport. By contrast, the molecular basis of aldosterone'
Autor:
Frieder Kees, Klaus Höcherl, Michael Bucher, Armin Kurtz, Hayo Castrop, Konrad Wolf, Karl Peter Ittner, Horst Grobecker
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 442:821-827
Based on recent evidence that renin gene and cyclooxygenase-2 (COX-2) expression in the rat kidney cortex increase in parallel under a variety of conditions, this study aimed to characterize the causal linkage between COX-2 and renin expression. Ther
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 442:577-587
In clonal rat somatomammotroph cells (GH3/ B6) Ca2+ influx through voltage-dependent Ca2+ channels is important for regulating the Ca2+ concentration that mediates hormone secretion. To study the Ca2+ channel subtypes in GH3/B6 cells, Ca2+ channel cu
Autor:
F. W. Reifarth, Luca Mastroberardino, Wolfgang Clauss, Wolf-Michael Weber, M. Schnizler, François Verrey
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 439:579-587
The rate of Na+ (re)absorption across tight epithelia such as in distal kidney nephron and colon is to a large extent controlled at the level of the epithelial Na+ channel (ENaC). In kidney, antidiuretic hormone (ADH, vasopressin) stimulates the expr
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 439:547-554
Using 3H-Tyr-d-Ala-Gly-Phe-d-Leu-OH (3H-DADLE) as a radioligand, δ-opioid binding sites on the IRD 98 rat epithelial cell line were identified. These sites were found to be reversible, saturable, specific and displayed high affinity for DADLE. Scatc
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 437:652-660
Glibenclamide is well known to interact with the sulphonylurea receptor (SUR) and has been shown more recently to inhibit the cystic fibrosis transmembrane conductance regulator protein (CFTR), both proteins that are members of the ABC [adenosine 5'-
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 437:596-602
The most abundant basolateral K+ channels in human colonic crypt cells have a low conductance (23 pS), respond to increases in intracellular Ca2+ and cAMP, and have been implicated in intestinal electrogenic Cl- secretion. The effect of nicardipine o
Autor:
Hans Willi Jansen, Schwark Jan-Robert, Hans-Jochen Lang, Wolfgang Krick, Gerhard Burckhardt, Max Dr Hropot
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 436:797-800
Inhibition of Na+/H+ exchange (NHE) subtypes has been investigated in a study of the mouse fibroblast L cell line (LAP1) transfected with human (h) NHE1, rabbit (rb) NHE2, rat (rt) or human (h) NHE3 as well as an opossum kidney cell line (OK) and por
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 436:712-716
We have previously investigated, in studies of rat distal colonic mucosa, the effect of ATP added to the basolateral side on ion transport and [Ca2+]i. It was demonstrated that ATP acts via a P2Y1 receptor to increase [Ca2+]i and NaCl secretion. In t