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Publikováno v:
Peptides. 123:170181
Previous studies suggested that endoplasmic reticulum (ER) stress induced-apoptosis promoted vascular calcification (VC). Interestingly, erythropoietin (EPO), an endogenous glycoprotein, exerts multiple tissue protective effects by inhibiting ER stre
Regulatory role of melatonin and BMP-4 in prolactin production by rat pituitary lactotrope GH3 cells
Autor:
Kanako Ogura-Ochi, Motoshi Komatsubara, Jun Wada, Fumio Otsuka, Kenichi Inagaki, Naoko Tsukamoto-Yamauchi, Nahoko Iwata, Yuki Nishiyama, Satoshi Fujisawa
Publikováno v:
Peptides. 94
The effects of melatonin on prolactin production and its regulatory mechanism remain uncertain. We investigated the regulatory role of melatonin in prolactin production using rat pituitary lactotrope GH3 cells by focusing on the bone morphogenetic pr
Publikováno v:
Peptides. 30:2337-2342
Objectives: Natriuretic peptides bind with natriuretic peptide receptor (NPR)-C, which can alter cellular function through its interaction with the G i protein complex. NPR-C has been found to mediate the activation of K + channels and non-selective
Publikováno v:
Peptides. 30:1448-1455
The orexigenic peptide ghrelin (GHREL) and obestatin (OBS) originate from the same peptide precursor, preproghrelin (ppGHREL). Apart from orexigenic effect, GHREL also regulates neuroendocrine function. We investigated GHREL and OBS effects on cortic
Autor:
Sigal Fleisher-Berkovich, Einat Levy
Publikováno v:
Peptides. 28:845-850
The aim of the present study was to investigate the short-term effect of bradykinin on the two cyclooxygenase species in neonatal rat glial cells. In spite of the fact that cyclooxygenase protein levels were not altered, an increase in cyclooxygenase
Publikováno v:
Peptides. 23:135-142
The present study examined whether a sustained increase in cytosolic Ca(2+) concentration ([Ca(2+)](i)) causes glucose-insensitivity in beta-cells and whether it could be modulated by pituitary adenylate cyclase-activating polypeptide (PACAP), a panc
Autor:
Josette Carnahan, Antoine Depaulis, Christian Marescaux, Sophie Reibel, Yves Larmet, Ramla Benmaamar, Suzan Nadi
Publikováno v:
Peptides. 22:529-539
In vitro and in vivo experiments suggest antiepileptic properties for NPY. In this study, the pharmacology of these effects was examined and compared in different rat models of seizures. Agonists for Y 1 , Y 2 and Y 5 receptors reduced seizure-like a
Autor:
Steven Z. Whetzel, Hyacinth C. Akunne, David Juergen Wustrow, Thomas G. Heffner, Lawrence D. Wise, Thomas A. Pugsley, A E Corbin, J.N. Wiley, S. Demattos
Publikováno v:
Peptides. 16:37-44
In in vitro studies, SR 48692, a nonpeptide neurotensin receptor antagonist, inhibited the binding of [3H] or [125I]neurotensin to membrane preparations from 10-day-old mouse brains and from HT-29 cells with Ki values of 3.9 and 8.6 nM, respectively.
Publikováno v:
Peptides. 37(1)
Angiotensin-(1-7) [Ang-(1-7)] plays a beneficial role in cardiovascular physiology by providing a counterbalance to the function of angiotensin II (Ang II). Although Ang II has been shown to be an adipokine secreted by adipocyte and affect lipid meta
Publikováno v:
Peptides. 35(2)
Production of n-octanoyl-modified ghrelin (GHREL), an active form of the peptide requires prohormone processing protease and GHREL O-acyltransferase (GOAT), as well as n-octanoic acid. Recently a selective GOAT antagonist (GO-CoA-Tat) was invented an