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Autor:
Ismail Koyuncu, Esra Cakir, Cüneyt Tayman, Mehmet Büyüktiryaki, Buse Ozer Bekmez, Ufuk Cakir, Tugba Taskin Turkmenoglu
Publikováno v:
Pediatric Research. 92:436-444
Background We aimed to compare the effect of dexamethasone (Dex), hydrocortisone (Hc), and methylprednisolone (Mpz) at equivalent doses on somatic growth, lung healing, and neurotoxicity in a hyperoxic rat model. We hypothesized that Mpz and Hc would
Autor:
Kathrine Skak Madsen, Camilla Gøbel Madsen, Peter Uldall, William F. C. Baaré, Alfred Peter Born, Olaf B. Paulson, Martin Vestergaard, Hartwig R. Siebner, Sara Krøis Holm
Publikováno v:
Pediatric Research. 91:879-887
Background Evidence suggests that fronto-limbic brain regions and connecting white matter fibre tracts in the left hemisphere are more sensitive to glucocorticoids than in the right hemisphere. It is unknown whether treatment with glucocorticoids in
Autor:
Leenah Abugisisa, Erin L. Fee, Fabrizio Salomone, Noah H. Hillman, Gabrielle C. Musk, Emily Royse, Judith Rittenschober-Böhm, Matthew W. Kemp, Alan H. Jobe
Publikováno v:
Pediatric Research
Background Chorioamnionitis is associated with increased rates of bronchopulmonary dysplasia (BPD) in ventilated preterm infants. Budesonide when added to surfactant decreased lung and systemic inflammation from mechanical ventilation in preterm lamb
Autor:
Derek de Winter, Karel Allegaert, Nathalie Berghen, Bieke Tack, Jan Deprest, Julio Jimenez, Jaan Toelen, Thomas Salaets, Andre Gie, Flore Lesage
Publikováno v:
Pediatric Research, 87(7), 1193-1200. Lippincott Williams & Wilkins
Bronchopulmonary dysplasia (BPD) remains a frequent complication following preterm birth, affecting respiratory health throughout life. Transcriptome analysis in a preterm rabbit model for BPD revealed dysregulation of key genes for inflammation, vas
Autor:
Prem S. Shekhawat, Samuel H. Pepkowitz, Donald W Chandler, Maroun J. Mhanna, Qiang Wu, Viral G. Jain, Tijen Karsli
Publikováno v:
Pediatric Research. 87:767-772
BACKGROUND Most neonatal outcomes in neonates are related to normal adrenal gland function. Assessment of adrenal function in a sick preterm neonate remains a challenge, thus we hypothesized that adrenal steroid precursors to their product ratios hav
Autor:
Liina Süvari, Markus Leskinen, P Anniina Palojärvi, M Anneli Kari, A Cecilia Janér, L Ursula Turpeinen, Otto Helve, Sture Andersson
Publikováno v:
Pediatric Research
BACKGROUND Antenatal glucocorticoids (GCs) reduce respiratory distress syndrome (RDS) in preterm infants and are associated with reduced lung liquid content. Our aim was to assess whether airway gene expression of mediators of pulmonary epithelial so
Autor:
Richard L. Auten, Chang Won Choi, Mulugu V. Brahmajothi, Beyong Il Kim, Erin N. Potts-Kant, Stanley N. Mason
Publikováno v:
Pediatric Research
Background: We previously showed that intra-amniotic lipopolysaccharide (LPS) amplifies alveolar hypoplasia induced by postnatal hyperoxia. We determined whether the priming effect of intra-amniotic LPS amplifies hyperoxia-induced airway hyperreactiv
Autor:
Dina K Gaynullina, Anastasia A. Shvetsova, Ekaterina K Selivanova, Olga S. Tarasova, Anna P. Sharova, A.A. Martyanov, Svetlana I. Sofronova
Publikováno v:
Pediatric Research. 84:112-117
Maternal thyroid deficiency can increase Rho-kinase procontractile influence in arteries of 2-week-old progeny. Here we hypothesized that augmented role of Rho-kinase persists in arteries from adult progeny of hypothyroid rats. Dams were treated with
Publikováno v:
Pediatric Research. 82:822-828
BackgroundMany adolescents are exposed to nicotine via smoking, e-cigarette use, or second-hand smoke. Nicotine-induced renal oxidative stress and its long-term consequences may be higher in adolescents than in adults because of intrinsic factors in
Publikováno v:
Pediatric research
Background Bronchopulmonary dysplasia (BPD) is a major morbidity in premature infants, and impaired angiogenesis is considered a major contributor to BPD. Early caffeine treatment decreases the incidence of BPD; the mechanism remains incompletely und