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Autor:
Wendy E. Ward, Ana V Piekarz
Publikováno v:
Pediatric Research. 61:48-53
Infants fed soy-based infant formulas are exposed to high levels of genistein, an isoflavone, with potential estrogen-like activity. This study determined whether neonatal exposure of mice to genistein resulted in higher bone mineral density (BMD) an
Autor:
Victor M Pulgar, Jorge P. Figueroa
Publikováno v:
Pediatric Research. 60:705-710
The effect of antenatal steroids on blood pressure in humans remains an unresolved question. Here we report the effects of prenatal exposure to clinically relevant doses of betamethasone on endothelial and/or vascular smooth muscle function. Pregnant
Publikováno v:
Pediatric Research. 59:56-60
Previous studies suggest that the endotoxin lipopolysaccharide (LPS) may have dual effects on brain damage induced by hypoxia-ischemia (HI) in 7-d-old rats, depending on the exposure paradigm. Although a 4-h interval between LPS administration and HI
Publikováno v:
Pediatric Research. 58:1180-1184
The purpose of this study was to investigate the effect of blue light phototherapy on the expression of circadian genes in peripheral blood mononuclear cells (PBMC) and plasma melatonin levels in neonates. Real-time reverse-transcriptase polymerase c
Autor:
Scott Fields, Ronald I. Clyman, Roberta L. Keller, Jacob V. Aranda, Theresa A. Tacy, John P. Ofenstein
Publikováno v:
Pediatric Research. 58:1216-1221
Studies in premature animals suggest that 1) prolonged tight constriction of the ductus arteriosus is necessary for permanent anatomic closure and 2) endogenous nitric oxide (NO) and prostaglandins both play a role in ductus patency. We hypothesized
Publikováno v:
Pediatric Research. 58:594-599
Exposure to intermittent hypoxia (IH), such as occurs in sleep-disordered breathing, is associated with increased apoptosis in vulnerable brain regions as well as with spatial reference memory deficits in adult and developing rats. The latter are mor
Publikováno v:
Pediatric Research. 58:297-301
Brain injury as a result of hypoxia-ischemia remains a common cause of morbidity and mortality in neonates. No effective therapy is currently available. The hematopoietic cytokine erythropoietin (Epo) provides neuroprotection in many adult models of
Publikováno v:
Pediatric Research. 58:58-65
Mean arterial pressure (MAP) increases after birth, however, the mechanisms remain unclear. Systemic angiotensin II (ANG II) infusions increase MAP in newborn sheep, but the direct effects of ANG II on peripheral vascular resistance (PVR) are minimal
Autor:
Arnold W. Strauss, Chonan Tokunaga, Ertan Mayatepek, Naomi van Vlies, Lodewijk IJlst, Frédéric M. Vaz, Ute Spiekerkoetter, Frits A. Wijburg, H. Overmars, Ronald J.A. Wanders, Udo Wendel, Marinus Duran
Publikováno v:
Pediatric research, 57(6), 760-764. Lippincott Williams and Wilkins
Deficiency of very-long-chain acyl-CoA dehydrogenase (VLCAD) is the most common long-chain fatty acid oxidation defect and presents with heterogeneous clinical manifestations. Accumulation of long-chain acylcarnitines and deficiency of free carnitine
Autor:
Michael K. Hoffmann, Thorsten W. Orlikowsky, Martin Eichner, Bärbel Spring, Christian F. Poets, Günther E. Dannecker
Publikováno v:
Pediatric Research. 57:656-661
The safety of dexamethasone for neonates has been questioned, partly because of its multiple unspecific effects on the immune system. Specific effects of dexamethasone on co-stimulatory and immune suppressive functions of neonatal compared with adult