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Prenatal Dexamethasone Treatment Improves Survival of Newborn Rats during Prolonged High O2 Exposure
Autor:
Lee Frank
Publikováno v:
Pediatric Research. 32:215-221
Prenatal dexamethasone (DEX) treatment is known to accelerate the maturation of both the surfactant system and the fetal lung antioxidant enzyme (AOE) system (Frank L, Lewis P, Sosenko IRS: Pediatrics 75:569–574, 1985). Because of this stimulatory
Publikováno v:
Pediatric Research. 30:522-527
Whereas glucocorticoid administration to pregnant rats produces parallel acceleration of lung surfactant and antioxidant enzyme system maturation in late gestation, prenatal thyroid hormone treatment results in acceleration of surfactant maturation,
Publikováno v:
Pediatric Research. 30:450-456
Renal clearance studies and morphologic observations were performed in rats aged 14, 21, and 28 d and 3, 6, 9, and 12 mo born with a 20% reduction in nephron number after administration of 75 mg/kg/d of gentamicin to their mothers during the second h
Autor:
Masafumi Matsuo, Tamaki Ohashi, Hajime Nakamura, Kimihiko Sano, Toshiyuki Motoike, Syuichi Tsuneishi, Satoshi Takada
Publikováno v:
Pediatric Research. 29:173-177
We have examined the effect of dexamethasone on the metabolism of pulmonary surfactant in normal and hyperoxia-treated rats. The relative abundance of the surfactant-specific apoprotein A (SP-A) mRNA in lung tissues and the contents of disaturated ph
Autor:
T. Tomomasa, Masahiko Tabata, Takayuki Tanaka, Paul E. Hyman, Mitsue Miyashita, Takayoshi Kuroume, Ken Itoh
Publikováno v:
Pediatric research. 31(2)
The gastric mucosa of newborn rats is sensitive to the damaging effects of acid and ethanol. We measured gastric mucus gel thickness in newborn, suckling, and weaned rats by inversion microscopic observation. The thickness in newborn rats was 52.2 +/
Autor:
Venkataraman Balaraman, Bruce E. Pichoff, Wayne M Ichimura, Kenneth T Nakamura, Linda K Kullama, John R. Claybaugh
Publikováno v:
Pediatric research. 29(3)
We examined the ontogeny of relaxation responses to three categories of calcium channel antagonists, represented by verapamil, diltiazem, and nifedipine, for both potential-operated (KCl-mediated) and receptor-operated channels [norepinephrine (NE)-m
Publikováno v:
Pediatric research. 28(1)
We studied the effect of early weaning from maternal breast milk to artificial diets on rat jejunal absorption of an exogenous 40-kD glycoprotein, horseradish peroxidase (HRP). Rat pups, fed maternal milk (MM) from birth, received one of three diets
Publikováno v:
Pediatric Research. 23:93-98
Previous studies have shown that salicylates and protein-calorie malnutrition compromise immunological responses in humans and experimental animals. The present study compared the effects of prenatal normal and low protein diets, with and without asp
Autor:
Dee A Hazlett, Patsy M. Brannon
Publikováno v:
Pediatric Research. 23:176-180
Chronic reserpine treatment (500 micrograms/kg) of the rat results in generalized exocrinopathy, impaired pancreatic secretion, and decreased pancreatic amylase. These characteristics are similar to those in cystic fibrosis and are the basis for use
Autor:
Philip G Holtzapple, Alan D. Bedrick
Publikováno v:
Pediatric Research. 20:598-601
Little is known about the role of oral prostaglandins and maintenance of intestinal epithelial cell membrane integrity in suckling animals. The presence of prostaglandins in milk suggests that they may have potential cytoprotective effects. Thus, exp