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Publikováno v:
Pediatric research
Background Bronchopulmonary dysplasia (BPD) is a major morbidity in premature infants, and impaired angiogenesis is considered a major contributor to BPD. Early caffeine treatment decreases the incidence of BPD; the mechanism remains incompletely und
Publikováno v:
Pediatric research. 85(5)
Renin-angiotensin system (RAS) blockade during nephrogenesis causes a broad range of renal mal-development. Here, we hypothesized that disruption of renal lymphangiogenesis may contribute to tubulointerstitial alterations after RAS blockade during ki
Publikováno v:
Pediatric research. 84(5)
When compared with infant formula, human milk enhances gastric emptying in preterm infants. Hydrogen peroxide (H2O2) is present in large quantities in human milk that has an antimicrobial role for the mother and infant. In vitro adult rat studies sug
Autor:
Oleg Palygin, Vladislav Levchenko, Daria V. Ilatovskaya, Alexander Staruschenko, Tengis S. Pavlov
Publikováno v:
Pediatric research
Autosomal recessive polycystic kidney disease is a genetic disorder characterized by the development of renal cysts of tubular epithelial cell origin. Epithelial Na(+) channel (ENaC) is responsible for sodium reabsorption in the aldosterone-sensitive
Autor:
Hauhui Wang, Bingming Chen, Kevin K. Noguchi, Moones Heidari, Gabrielle N. Turski, Ian D. Duncan, Cara J. Westmark, Lingjun Li, Chrysanthy Ikonomidou, Christopher A. Turski
Publikováno v:
Pediatric research. 83(6)
BACKGROUND: Pelizaeus Merzbacher disease (PMD) is a dysmyelinating disorder of the central nervous system caused by impaired differentiation of oligodendrocytes. This study was prompted by findings that antimuscarinic compounds enhance oligodendrocyt
Publikováno v:
Pediatric Research. 69:378-383
Both the renin-angiotensin-aldosterone system (RAAS) and hypoxia are vital physiological factors involved in the control of nephrogenesis and vascularization. We investigated the relationship between RAAS and hypoxia in the developing kidney. The exp
Autor:
Feike R. van der Leij, Yan Liu
Publikováno v:
Pediatric Research. 69:148-153
Because L-carnitine (L-CAR) is a potential substitute for neonatal dexamethasone (DEX) with respect to the prevention of long-term side effects, rats were treated on d 1, 2, and 3 after birth with saline, DEX, L-CAR, half the dose of DEX, and L-CAR +
Publikováno v:
Pediatric Research. 67:173-176
Furosemide increases prostaglandin production and may be associated with patent ductus arteriosus (PDA). We aimed to clarify the in vivo ductus-dilating effects of furosemide in neonatal rats. Near-term rat pups delivered by a cesarean section were h
Autor:
Willem B. de Vries, Roel Goldschmeding, Miriam P Bal, Roel A. de Weger, Frank van Bel, Pleunie van den Borne, Matthijs F.M. van Oosterhout
Publikováno v:
Pediatric Research. 67:72-76
Recently, concern has been raised that corticosteroid treatment of preterm neonates might be associated with adverse effects later in life, including early development of hypertension. Here, we investigate the impact of neonatal dexamethasone (Dex) t
Publikováno v:
Pediatric Research. 64:234-239
Periventricular white matter injury is the leading cause of cerebral palsy in premature infants for which no effective treatments are available. Our previous studies have demonstrated that pharmacological activation of the cAMP response element-bindi