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Autor:
Leenah Abugisisa, Erin L. Fee, Fabrizio Salomone, Noah H. Hillman, Gabrielle C. Musk, Emily Royse, Judith Rittenschober-Böhm, Matthew W. Kemp, Alan H. Jobe
Publikováno v:
Pediatric Research
Background Chorioamnionitis is associated with increased rates of bronchopulmonary dysplasia (BPD) in ventilated preterm infants. Budesonide when added to surfactant decreased lung and systemic inflammation from mechanical ventilation in preterm lamb
Autor:
Prem S. Shekhawat, Samuel H. Pepkowitz, Donald W Chandler, Maroun J. Mhanna, Qiang Wu, Viral G. Jain, Tijen Karsli
Publikováno v:
Pediatric Research. 87:767-772
BACKGROUND Most neonatal outcomes in neonates are related to normal adrenal gland function. Assessment of adrenal function in a sick preterm neonate remains a challenge, thus we hypothesized that adrenal steroid precursors to their product ratios hav
Publikováno v:
Pediatric research
Background Bronchopulmonary dysplasia (BPD) is a major morbidity in premature infants, and impaired angiogenesis is considered a major contributor to BPD. Early caffeine treatment decreases the incidence of BPD; the mechanism remains incompletely und
Autor:
Boris W. Kramer, Suhas G. Kallapur, Matthew W. Kemp, Alan H. Jobe, Augusto F. Schmidt, Paranthaman S. Kannan, John P. Newnham
Publikováno v:
Pediatric Research, 81(3), 496-503. Nature Publishing Group
BACKGROUND: Dexamethasone-phosphate (Dex-PO4) and the combination betamethasone-phosphate (Beta-PO4) + betamethasone-acetate (Beta-Ac) are the most used antenatal corticosteroids to promote fetal lung maturation. We compared fetal lung maturation ind
Publikováno v:
Jakobsen, L K, Trelborg, K F, Simonsen, U, Andersson, K-E & Olsen, L H 2018, ' Development of contractile properties in the fetal porcine urinary bladder ', Pediatric Research, vol. 83, pp. 148–155 . https://doi.org/10.1038/pr.2017.181
BackgroundIn early fetal life, the bladder is merely a conduit allowing urine to pass through freely into the amniotic cavity. As the striated external urethral sphincter evolves, the bladder acquires its reservoir and voiding functions. We character
Publikováno v:
Pediatric Research. 69:212-216
Ibuprofen-induced ductus closure improves pulmonary mechanics and increases alveolar surface area in premature baboons compared with baboons with a persistent patent ductus arteriosus (PDA). Ibuprofen-treatment has no effect on the expression of gene
Publikováno v:
Pediatric Research. 68:462-465
We have used aminoterminal pro C-type natriuretic peptide (NTproCNP)--a stable marker of CNP secretion--to study the effect of cortisol on CNP secretion and fetal growth. In ovine pregnancy, maternal plasma NTproCNP (largely sourced from the placenta
Publikováno v:
Pediatric Research. 67:173-176
Furosemide increases prostaglandin production and may be associated with patent ductus arteriosus (PDA). We aimed to clarify the in vivo ductus-dilating effects of furosemide in neonatal rats. Near-term rat pups delivered by a cesarean section were h
Autor:
Megan J. Wallace, Kelly J. Crossley, Beth J. Allison, Graeme R. Polglase, Colin J Morley, Stuart B. Hooper, Valerie A. Zahra, Peter G Davis
Publikováno v:
Pediatric Research. 66:283-288
The lungs of very preterm infants have immature airways and gas exchange structures and are usually surfactant deficient. Antenatal corticosteroids are commonly used to enhance fetal lung maturation in preterm infants, but little is known of their ef
Autor:
Luigi Raio, Myriam Aufdenblatten, Bernhard Dick, Henning Schneider, Daniel Surbek, Berthold Hocher, Marc Baumann, Brigitte M. Frey, Markus G. Mohaupt
Publikováno v:
Pediatric Research. 65:198-202
Fetal growth is compromised in animal models with high cortisol availability. In healthy pregnancies, the fetus is protected from high circulating cortisol levels by the placental 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which is red