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Publikováno v:
Pediatric Research. 68:462-465
We have used aminoterminal pro C-type natriuretic peptide (NTproCNP)--a stable marker of CNP secretion--to study the effect of cortisol on CNP secretion and fetal growth. In ovine pregnancy, maternal plasma NTproCNP (largely sourced from the placenta
Autor:
Luigi Raio, Myriam Aufdenblatten, Bernhard Dick, Henning Schneider, Daniel Surbek, Berthold Hocher, Marc Baumann, Brigitte M. Frey, Markus G. Mohaupt
Publikováno v:
Pediatric Research. 65:198-202
Fetal growth is compromised in animal models with high cortisol availability. In healthy pregnancies, the fetus is protected from high circulating cortisol levels by the placental 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which is red
Autor:
Alva Lee Carter, Ikumi Tamai, Han Soo Yang, Prem S. Shekhawat, Vadivel Ganapathy, Michael J. Bennett, Dietrich Matern
Publikováno v:
Pediatric Research. 56:323-328
Placenta requires energy to support its rapid growth, maturation, and transport function. Fatty acids are used as energy substrates in placenta, but little is known about the role played by carnitine in this process. We have investigated the role of
Publikováno v:
Pediatric Research. 52:706-712
Antenatal glucocorticoids are routinely given to women at risk for preterm delivery. The fetus is protected from excessive glucocorticoids by the placental enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD-2), which catalyzes the conversi
Publikováno v:
Pediatric Research. 44:656-662
The aims of this study were to determine whether placental restriction (PR) alters the pattern of localization of the catecholamine-synthesizing enzymes, dopamine-beta-hydroxylase and phenylethanolamine N-methyltransferase, and enkephalin (ENK)-conta
Autor:
Amanda K Rourke, Julie A. Owens, I. Caroline McMillen, Jeffrey S. Robinson, Giuseppe Simonetta
Publikováno v:
Pediatric Research. 42:805-811
We have investigated the impact of chronic restriction of placental function on circulating catecholamine concentrations and responses to the indirectly acting, sympathomimetic amine, tyramine, in the fetal sheep in late gestation. In 10 ewes, endome
Publikováno v:
Pediatric research. 59(4 Pt 1)
The placental enzyme 11beta-hydroxysteroid dehydrogenase-2 (11beta-HSD2) transforms maternal cortisol to inactive cortisone. Fetal glucocorticoid excess due to reduced 11beta-HSD2 activity could make small preterm infants susceptible to early adrenal
Publikováno v:
Pediatric research. 46(3)
Granulocyte colony-stimulating factor (G-CSF) promotes neutrophil proliferation, differentiation, and survival. It acts by binding to specific cell-surface receptors (G-CSF-R), which are expressed on cells of granulocytic lineage, human endothelial c
Autor:
Kerstin Brismar, Christine Carlsson-Skwirut, Peter Fibiger Bang, Annica Sohlström, Kerstin Uvnäs-Moberg
Publikováno v:
Karolinska Institutet
The effects of oxytocin on fetal and placental growth and on maternal weight gain and accumulation of body fat were studied in ad libitum-fed and food-restricted (receiving 70% of the food intake of the ad libitum-fed group) pregnant rats. Further, a
Publikováno v:
Pediatric research. 41(2)
Fetal hepatic amino acid metabolism has unique features in comparison to postnatal life. Thus, it seemed likely that this metabolism might be changed by the endocrine changes which precede birth. To explore the changes in placental and fetal carbohyd