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Autor:
Kathrine Skak Madsen, Camilla Gøbel Madsen, Peter Uldall, William F. C. Baaré, Alfred Peter Born, Olaf B. Paulson, Martin Vestergaard, Hartwig R. Siebner, Sara Krøis Holm
Publikováno v:
Pediatric Research. 91:879-887
Background Evidence suggests that fronto-limbic brain regions and connecting white matter fibre tracts in the left hemisphere are more sensitive to glucocorticoids than in the right hemisphere. It is unknown whether treatment with glucocorticoids in
Autor:
Liina Süvari, Markus Leskinen, P Anniina Palojärvi, M Anneli Kari, A Cecilia Janér, L Ursula Turpeinen, Otto Helve, Sture Andersson
Publikováno v:
Pediatric Research
BACKGROUND Antenatal glucocorticoids (GCs) reduce respiratory distress syndrome (RDS) in preterm infants and are associated with reduced lung liquid content. Our aim was to assess whether airway gene expression of mediators of pulmonary epithelial so
Publikováno v:
Pediatric Research. 82:822-828
BackgroundMany adolescents are exposed to nicotine via smoking, e-cigarette use, or second-hand smoke. Nicotine-induced renal oxidative stress and its long-term consequences may be higher in adolescents than in adults because of intrinsic factors in
Autor:
Boris W. Kramer, Suhas G. Kallapur, Matthew W. Kemp, Alan H. Jobe, Augusto F. Schmidt, Paranthaman S. Kannan, John P. Newnham
Publikováno v:
Pediatric Research, 81(3), 496-503. Nature Publishing Group
BACKGROUND: Dexamethasone-phosphate (Dex-PO4) and the combination betamethasone-phosphate (Beta-PO4) + betamethasone-acetate (Beta-Ac) are the most used antenatal corticosteroids to promote fetal lung maturation. We compared fetal lung maturation ind
Autor:
Gideon Koren, Lauren E. Kelly, Stephanie Baello, Jessica Lam, David Chitayat, Stephen G. Matthews, Majid Iqbal, Patrick Shannon
Publikováno v:
Pediatric Research. 78:417-421
Neonates have been shown to have a heightened sensitivity to the central depressive effects of opioids compared to older infants and adults. The limited development of P-glycoprotein (P-gp) may limit the ability of the neonate to efflux morphine from
Autor:
Hauhui Wang, Bingming Chen, Kevin K. Noguchi, Moones Heidari, Gabrielle N. Turski, Ian D. Duncan, Cara J. Westmark, Lingjun Li, Chrysanthy Ikonomidou, Christopher A. Turski
Publikováno v:
Pediatric research. 83(6)
BACKGROUND: Pelizaeus Merzbacher disease (PMD) is a dysmyelinating disorder of the central nervous system caused by impaired differentiation of oligodendrocytes. This study was prompted by findings that antimuscarinic compounds enhance oligodendrocyt
Publikováno v:
Jakobsen, L K, Trelborg, K F, Simonsen, U, Andersson, K-E & Olsen, L H 2018, ' Development of contractile properties in the fetal porcine urinary bladder ', Pediatric Research, vol. 83, pp. 148–155 . https://doi.org/10.1038/pr.2017.181
BackgroundIn early fetal life, the bladder is merely a conduit allowing urine to pass through freely into the amniotic cavity. As the striated external urethral sphincter evolves, the bladder acquires its reservoir and voiding functions. We character
Publikováno v:
Pediatric Research. 69:285-292
Critically ill preterm infants experience multiple stressors while hospitalized. Morphine is commonly prescribed to ameliorate their pain and stress. We hypothesized that neonatal stress will have a dose-dependent effect on hippocampal gene expressio
Publikováno v:
Pediatric Research. 64:234-239
Periventricular white matter injury is the leading cause of cerebral palsy in premature infants for which no effective treatments are available. Our previous studies have demonstrated that pharmacological activation of the cAMP response element-bindi
Publikováno v:
Pediatric Research. 63:620-624
Preconditioning with hypoxia and hypoxia-mimetic compounds cobalt chloride (CoCl2) and desferrioxamine (DFX) protects against hypoxic-ischemic (HI) injury in neonatal rat brain. We examined long-term functional and protective actions of preconditioni