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Autor:
Ismail Koyuncu, Esra Cakir, Cüneyt Tayman, Mehmet Büyüktiryaki, Buse Ozer Bekmez, Ufuk Cakir, Tugba Taskin Turkmenoglu
Publikováno v:
Pediatric Research. 92:436-444
Background We aimed to compare the effect of dexamethasone (Dex), hydrocortisone (Hc), and methylprednisolone (Mpz) at equivalent doses on somatic growth, lung healing, and neurotoxicity in a hyperoxic rat model. We hypothesized that Mpz and Hc would
Publikováno v:
Pediatric Research. 68:462-465
We have used aminoterminal pro C-type natriuretic peptide (NTproCNP)--a stable marker of CNP secretion--to study the effect of cortisol on CNP secretion and fetal growth. In ovine pregnancy, maternal plasma NTproCNP (largely sourced from the placenta
Autor:
Luigi Raio, Myriam Aufdenblatten, Bernhard Dick, Henning Schneider, Daniel Surbek, Berthold Hocher, Marc Baumann, Brigitte M. Frey, Markus G. Mohaupt
Publikováno v:
Pediatric Research. 65:198-202
Fetal growth is compromised in animal models with high cortisol availability. In healthy pregnancies, the fetus is protected from high circulating cortisol levels by the placental 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which is red
Autor:
Laura Bennet, Mhoyra Fraser, Andrew S. Naylor, Joanne O. Davidson, Vincent Roelfsema, Alistair J. Gunn
Publikováno v:
Pediatric Research. 63:51-55
The hypothalamic-pituitary-adrenal (HPA) axis is essential for adaptation to stress. In the present study, we examined the hypothesis that head cooling with mild systemic hypothermia would adversely affect fetal adrenocorticotropic hormone (ACTH) and
Publikováno v:
Pediatric Research. 52:706-712
Antenatal glucocorticoids are routinely given to women at risk for preterm delivery. The fetus is protected from excessive glucocorticoids by the placental enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD-2), which catalyzes the conversi
Autor:
H N Lafeber, Fred G J Sweep, Corrie Popp-Snijders, Henriette A. Delemarre-van de Waal, R. J. Bolt, Mirjam M. van Weissenbruch
Publikováno v:
Pediatric Research. 52:405-410
To study the maturity of the adrenal cortex in preterms born before 33 wk of gestation, basal levels of cortisol and cortisone and the cortisol and 17-hydroxyprogesterone (17-OHP) response to 1 microg/kg adrenocorticotropic hormone stimulation were m
Publikováno v:
Scopus-Elsevier
Intrauterine growth retardation (IUGR) is one of the major causes of short stature in childhood. Although postnatal catch-up growth occurs in the majority of IUGR children, approximately 20% of them remain permanently short. The mechanisms that allow
Publikováno v:
Pediatric Research. 46:189-193
We evaluated the involvement of a possible dysfunction of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) in the fetal growth retardation and poor growth rates of children born with intrauterine growth retardation (IUGR). Children with IUGR
Publikováno v:
Pediatric Research. 44:887-893
The fetal zone of the adrenal gland is known to persist after preterm birth, but there is uncertainty as to how long adrenal fetal zone steroid production continues and how it is regulated. The purpose of this study was to test two hypotheses. First,
Publikováno v:
Pediatric Research. 40:330-336
We investigated the effect of a beta 3-adrenergic agonist, Zeneca D7114, on thermoregulation in near-term lambs delivered by cesarean section. Lambs were delivered into a cool ambient temperature of 15 degrees C, and between 60 and 80 min of life wer