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Autor:
Kathrine Skak Madsen, Camilla Gøbel Madsen, Peter Uldall, William F. C. Baaré, Alfred Peter Born, Olaf B. Paulson, Martin Vestergaard, Hartwig R. Siebner, Sara Krøis Holm
Publikováno v:
Pediatric Research. 91:879-887
Background Evidence suggests that fronto-limbic brain regions and connecting white matter fibre tracts in the left hemisphere are more sensitive to glucocorticoids than in the right hemisphere. It is unknown whether treatment with glucocorticoids in
Autor:
Liina Süvari, Markus Leskinen, P Anniina Palojärvi, M Anneli Kari, A Cecilia Janér, L Ursula Turpeinen, Otto Helve, Sture Andersson
Publikováno v:
Pediatric Research
BACKGROUND Antenatal glucocorticoids (GCs) reduce respiratory distress syndrome (RDS) in preterm infants and are associated with reduced lung liquid content. Our aim was to assess whether airway gene expression of mediators of pulmonary epithelial so
Publikováno v:
Pediatric Research, 86, 28-38
Pediatric Research, 86, 1, pp. 28-38
Pediatric Research, 86, 1, pp. 28-38
The ductus arteriosus (DA) is probably the most intriguing vessel in postnatal hemodynamic transition. DA patency in utero is an active state, in which prostaglandin E2 (PGE2) and nitric monoxide (NO), play an important role. Since the DA gets progra
Autor:
Gideon Koren, Lauren E. Kelly, Stephanie Baello, Jessica Lam, David Chitayat, Stephen G. Matthews, Majid Iqbal, Patrick Shannon
Publikováno v:
Pediatric Research. 78:417-421
Neonates have been shown to have a heightened sensitivity to the central depressive effects of opioids compared to older infants and adults. The limited development of P-glycoprotein (P-gp) may limit the ability of the neonate to efflux morphine from
Publikováno v:
Pediatric Research. 72:262-269
Plasma proteins are known to interfere with pulmonary surfactant. Studies have proven the hypothesis that fibrinogen preserves exogenous surfactant subjected to long-term surface area cycling. The exogenous surfactant Curosurf was subjected to long-t
Publikováno v:
Pediatric Research. 69:285-292
Critically ill preterm infants experience multiple stressors while hospitalized. Morphine is commonly prescribed to ameliorate their pain and stress. We hypothesized that neonatal stress will have a dose-dependent effect on hippocampal gene expressio
Publikováno v:
Pediatric Research. 69:212-216
Ibuprofen-induced ductus closure improves pulmonary mechanics and increases alveolar surface area in premature baboons compared with baboons with a persistent patent ductus arteriosus (PDA). Ibuprofen-treatment has no effect on the expression of gene
Publikováno v:
Pediatric Research. 68:462-465
We have used aminoterminal pro C-type natriuretic peptide (NTproCNP)--a stable marker of CNP secretion--to study the effect of cortisol on CNP secretion and fetal growth. In ovine pregnancy, maternal plasma NTproCNP (largely sourced from the placenta
Interleukin-10 Versus Dexamethasone: Effects on Polymorphonuclear Leukocyte Functions of the Newborn
Publikováno v:
Pediatric Research. 65:425-429
Interleukin-10 (IL-10), an anti-inflammatory cytokine, may have therapeutic potential in the fetal inflammatory response syndrome and its sequelae such as bronchopulmonary dysplasia (BPD). Our aim was to compare the effects of IL-10 versus dexamethas
Autor:
Luigi Raio, Myriam Aufdenblatten, Bernhard Dick, Henning Schneider, Daniel Surbek, Berthold Hocher, Marc Baumann, Brigitte M. Frey, Markus G. Mohaupt
Publikováno v:
Pediatric Research. 65:198-202
Fetal growth is compromised in animal models with high cortisol availability. In healthy pregnancies, the fetus is protected from high circulating cortisol levels by the placental 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which is red