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Autor:
Fangning Pang, Wei He, Xuantong Liu, Zheng Zou, Weidong Wu, Yu Wang, Peng Yang, Bin Wen, Jinquan Jiang, Yunpeng Teng, Xinyu Yang, Ligang Chen, Qingge Jia, Mingyang Li, Jin Xu
Publikováno v:
Pathology - Research and Practice. 240:154236
PRKCH is a member of the PKC family with the potential to regulate cell proliferation and differentiation. Glioma is the most common primary tumor of the central nervous system, with a high recurrence rate and poor prognosis. Recent studies have demo
Publikováno v:
Pathology - Research and Practice. 215:525-531
Osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) is quite important for the bone formation. Bone morphogenetic proteins (BMPs) are important to the skeleton formation. As a member of BMPs, BMP1 can induce bone a
Publikováno v:
Pathology - Research and Practice. 233:153822
Currently, recurrence and metastasis are still the main causes leading to the failure of various therapies for malignant tumors. In view of this, research on cancer stem cells (CSCs) has received increasing attention. CSCs are a subgroup of cancer ce
Autor:
Alberto Paniz-Mondolfi, Parnian Ahmadi Moghaddam, Gustavo Benaim, Meenakshi Mehrotra, Mandana Mahmoodi, Rajyalakshmi Luthra, Rajesh R. Singh
Publikováno v:
Pathology - Research and Practice. 214:1898-1903
Autor:
Naoki Wada, Keisuke Kawasaki, Kenji Ohshima, Satoshi Nojima, Eiichi Morii, Shinya Kusumoto, Masako Kurashige, Shinichiro Tahara, Mitsuyo Tone, Jun-ichiro Ikeda
Publikováno v:
Pathology - Research and Practice. 214:1667-1674
Glutamine (Gln) is important not only for cell proliferation but also for differentiation. Although Gln is essential for plasmacytic differentiation of lymphocytes, no study has been done on the effect of Gln on differentiation of tumor cells, such a
Autor:
Takahiro Watanabe, Shohei Matsuo, Seiichi Hirota, Hiroyuki Futani, Takako Kihara, Shinichi Yoshiya, Yoshitane Tsukamoto
Publikováno v:
Pathology - Research and Practice. 213:1315-1321
We experienced a 38-year-old Japanese male with t(10;19) CIC-DUX4 -positive undifferentiated small round cell sarcoma in the deep abdominal wall. Three months before his first visit to our hospital, he noticed a mass in his right abdominal wall. Comp
Publikováno v:
Pathology - Research and Practice. 222:153416
Synovial sarcoma (SS) is an aggressive malignancy of an unknown tissue origin that is characterized by biphasic differentiation. A possible basis of the pathogenesis of SS is pathognomonic t(X;18) (p11.2; q11.2) translocation, leading to the formatio
Publikováno v:
Pathology - Research and Practice. 220:153378
Cancer comprises epithelial tumor cells and associated stroma, often times referred to as the "tumoral microenvironment". Cancer-associated fibroblasts (CAFs) are the most notable components of the tumor mesenchyme. CAFs promote the initiation of can
Autor:
Francisco Giner, Isidro Machado, José Antonio López-Guerrero, Samuel Navarro, Laura Verdini, Antonio Llombart-Bosch, Piero Picci
Publikováno v:
Pathology - Research and Practice. 219:153362
Given the potential for neuroendocrine differentiation in Ewing's sarcoma family of tumors (ESFT), we aimed to determine neuroendocrine expression in a large series of genetically-confirmed ESFT and its prognostic significance in clinically-localised
Autor:
Nae Yu Kim, Jung-Soo Pyo
Publikováno v:
Pathology - Research and Practice. 213:778-782
Objective The aim of this study was to investigate the clinicopathological characteristics and prognostic role of enhancer of zeste homologue 2 (EZH2) expression in non-small cell lung cancer (NSCLC). Methods The correlation between EZH2 expression a