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Publikováno v:
Pathology & Oncology Research. 26:2733-2745
Tumor immune microenvironment (TIME) is a significant prognostic parameter for triple negative breast carcinomas (TNBC) due to being a target for immunotherapeutic agents and its essential role during the cancer immunoediting process. In this study,
Autor:
Snezana Susnjar, Gordana Supic, Bojana Uzelac, Zorka Milovanovic, Ana Krivokuca, Mirjana Branković-Magić, Zvonko Magic
Publikováno v:
Pathology & Oncology Research. 26:2723-2731
Triple-negative breast cancer (TNBC) is characterized by aggressive phenotype and a poorer prognosis compared to the estrogen and progesterone receptor positive, Her2 negative (ER + PR + Her2-) breast cancer. Increasing evidence suggests that sirtuin
Autor:
Faruk Tas, Kayhan Erturk
Publikováno v:
Pathology & Oncology Research. 26:2483-2487
The clinical significances of de novo and nevus-associated melanomas are controversial. In this study, we investigated the correlations of these forms of melanomas in respect to their pathological and clinical features and patient outcomes. The data
Autor:
Damiana Antonia Faè, Riccardo Dolcetti, Debora Martorelli, Luigi Barzan, Carlo Gobitti, E. Comaro, F. Navarria, C. Furlan, Giuseppe Fanetti, Sandro Sulfaro, Elena Muraro, Agostino Steffan, Giovanni Franchin, Chiara Pratesi, Stefania Zanussi, Emanuela Vaccher, Valentina Lupato, Jerry Polesel, Michela Cangemi, Vittorio Giacomarra, Vincenzo Canzonieri, C. Scaini, Giuseppe Grando, Elisabetta Fratta
Publikováno v:
Pathology & Oncology Research. 26:2459-2467
Undifferentiated Nasopharyngeal Carcinoma (UNPC) is associated with Epstein-Barr Virus (EBV) and characterized by an abundant immune infiltrate potentially influencing the prognosis. Thus, we retrospectively assessed the significance of immunosuppres
Publikováno v:
Pathology & Oncology Research. 26:2363-2370
High-grade neuroendocrine tumors (HGNET) have distinctive tumor biology/behaviour. Newer modalities of treatment (immunotherapy) for them have been included in recent NCCN guidelines. Detection of programmed death receptor-ligand 1 (PD-L1) expression
Autor:
Emine Kilic Bagir, Ahmet Güzel, Semra Paydas, Ümran Küçükgöz Güleç, Mehmet Ali Vardar, Ghanim Khatib
Publikováno v:
Pathology & Oncology Research. 26:2351-2356
Although the prognostic significance of grade in endometrial cancer is well known, grade 2 cases have not been evaluated separately in most of the previous studies. In this study, we aim to investigate whether the oncologic outcomes of grade 2 endome
Autor:
Miklós Máthé, Tibor Füle, Lászlóné Oláh, Renáta Vigh, Zoltán Papp, Katalin Karaszi, Ilona Kovalszky, Alexandra Fullár
Publikováno v:
Pathology Oncology Research
Syndecan-1, is a transmembrane heparan/chondroitin sulfate proteoglycan necessary for cell-cell and cell-matrix interactions. Its decreased level on the cell surface correlates with poor prognosis in several tumor types. Aberrant stromal localization
Autor:
Tomasz Rutkowski, Ewa Chmielik, Ewa Małusecka, Monika Giglok, Rafał Suwiński, Dariusz Lange, Agnieszka M. Mazurek
Publikováno v:
Pathology Oncology Research
Human papilloma virus (HPV) is highly frequent among patients with anal squamous cell carcinoma, but the viral load (VL) differs between patients. This study aimed to compare the rate of HPV positivity, HPV16VL, p16INK4A and p53 expression between tr
Autor:
Yahang Liang, Jianhong Ye, Xiaolong Tang, Jingbo Shi, Hui Qu, Qingsi He, Guorui Sun, Jia Liu, Lei Gao
Publikováno v:
Pathology & Oncology Research. 26:2169-2175
Synchronous multiple gastric cancer (SMGC) was a special type of gastric cancer with relatively low incidence. This article was designed to demonstrate that the total tumor volume (TTV) should be treated as an important prognostic factor in SMGC pati
Autor:
Tímea Szekerczés, Katalin Borka, Gábor Lendvai, Zsuzsa Schaff, Gógl A, András Kiss, Ildikó Illyés, Klára Werling, József Mandl
Publikováno v:
Pathology Oncology Research
Although the role of autophagy has been implicated in several forms of chronic hepatitis, it is still not fully understood. Active autophagy eliminates damaged molecules and organelles (such as mitochondria) by lysosomal degradation. In the present s