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Publikováno v:
Pathology, research and practice. 229
Endometrioid carcinoma (EC) is classified into 3 histological subtypes; Grade 1 (G1), Grade 2 (G2), and Grade 3 (G3). Although the prognosis is relatively good in G1, some G1 cases are more aggressive, which are called G1 with MELF (microcystic, elon
Autor:
Viviana Sanza, Giorgia Acquaviva, Andrea Vacirca, Gianandrea Pasquinelli, Dario de Biase, Mauro Gargiulo, Francesco Vasuri
Publikováno v:
Pathology, research and practice. 229
Introduction: Different models have been proposed for the prediction of the risk/benefit ratio of surgery in patients with carotid atheromasic disease, mainly based on clinical patients’ characteristics and risk factors, but no definite biological
Publikováno v:
Pathology, research and practice. 229
The dynamic balance between ubiquitination and deubiquitination is a key mechanism that regulates protein degradation and maintains cell protein homeostasis. Ubiquitin-specific peptidase 13 (USP13), a deubiquitinase (DUB), regulates various physiolog
Publikováno v:
Pathology, research and practice. 227
Signal transducer and activator of transcription-3 (STAT3) is an important member of the STAT family. Studies have found that it can participate in cell signal transduction and transcriptional activation. STAT3 plays an important role in tumor angiog
Publikováno v:
Pathology, research and practice. 227
Aims HER2 and osteopontin (OPN) are both important biomarkers in gastric cancer (GC). The relationships between them remain to be revealed. The purpose of this study is to explore the role of OPN in epithelial-mesenchymal transition (EMT) in HER2 pos
Autor:
Fernando Ortiz-Martínez, Marta García-Escolano, Araceli García-Martínez, Elena Castellon-Molla, Eloy Pomares-Navarro, Gloria Peiró, Elena Sanmartín, Yoel G. Montoyo-Pujol, Ariadna Perez-Balaguer
Publikováno v:
Pathology, research and practice. 223
Purpose Hedgehog (Hh) signaling is a crucial developmental regulatory pathway recognized as a primary oncogenesis driver in various human cancers. However, its role in breast carcinoma (BC) has been underexplored. Methods We analyzed the expression o
Publikováno v:
Pathology, research and practice. 225
Background O-linked β-N-acetylglucosamine transferase (O-GlcNAc transferase, OGT) is a key enzyme that regulates O-GlcNAc modification, which is significantly up-regulated and participates in the regulation of tumorigenesis. Although previous resear
Publikováno v:
Pathology, research and practice. 224
B7-H3 is a type I membrane protein that has contradictory co-stimulatory and co-inhibitory effects in adaptive and anti-tumour immunity. B7-H3 is up-regulated in many malignant tumours, including breast cancer. Therefore, we hypothesise that B7-H3, w
Publikováno v:
Pathology, research and practice. 222
Epstein-Barr virus (EBV) infection is closely related to gastric carcinoma (GC). In this study, we identified a set of DEGs (different expression genes) between EBVaGC (EBV-associated gastric carcinoma) and EBVnGC (EBV-negative gastric carcinoma) thr
Autor:
Qian Sun, Jian Yang, Gang Deng, Shenqi Zhang, Yang Xu, Yuan Fan'en, Huikai Zhang, Baohui Liu, Junhui Liu, Qianxue Chen
Publikováno v:
Pathology, research and practice. 222
Increasing literature reported that circRNAs play vital roles in the occurrence and progression of GBM and regulate GBM cell proliferation, metastases, and chemosensitivity. However, the expression pattern and function of circRNAs in GBM still need f