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Publikováno v:
Pathology, research and practice. 214(4)
Epithelial-mesenchymal transition (EMT) is a process which epithelial cells gain mesenchymal phenotype such as motility and invasiveness. We investigated the role of EMT in upper urinary tract urothelial carcinoma (UTUC). The patient cohort included
Autor:
Priscilla Brebi, Juan Carlos Roa, Kurt Buchegger, Jaime Lopez, Pamela Leal, Juan Carlos Araya, Ramón Silva, Ismael Riquelme, Carmen Ili
Publikováno v:
Pathology, research and practice. 213(5)
Gallbladder cancer (GBC) is a highly fatal disease with poor prognosis and few therapeutic alternatives. Molecular profiling has revealed that the deregulation in the ERK/MAPK signaling pathway plays a crucial role in many disease and malignancies, i
Publikováno v:
Pathology, research and practice. 211(12)
Background Wnt5a, a non-canonical Wnt ligand, has been shown to play tumor-promoting or tumor-suppressive roles in different neoplasms. Increased Wnt5a expression and Wnt5a-dependent invasive activity that is mediated by one of its receptors, Ryk, ha
Autor:
Mi Kyung Kim, Tae Jin Lee, Kyung Ho Kang, Hee Sung Kim, Yoon Yang Jung, Eon Sub Park, Yun Jae Chung, Hwa Young Ahn, Jae Hyung Yoo, Bo Youn Cho
Publikováno v:
Pathology, research and practice. 211(2)
The BRAF(V600E) mutation is the most common genetic alteration in papillary thyroid carcinoma (PTC). The aim of this study is to analyze the clinicopathologic correlations of the BRAF(V600E) mutation, BRAF V600E immunohistochemistry (IHC) and BRAF RN
Autor:
Eun Hee Lee, Sang Bong Jung, Hyoun Wook Lee, Kyungeun Kim, Moon-il Park, Mee-Seon Kim, Mee Sook Roh, Seok-Hyun Kim
Publikováno v:
Pathology, research and practice. 211(4)
Multiple intracellular transforming signals regulate eukaryotic translation initiation factor 4E (eIF4E)-binding protein (4E-BP1). The signals result in hierarchical phosphorylation of 4E-BP1, resulting in release of eIF4E, relieving translational re
Publikováno v:
Pathology, research and practice. 209(10)
SIRT1 and p300/CBP, which are considered to be essential histone deacetylases and acetyltransferases, are also considered to be relative to tumorigenesis because they modulate the expression of several tumor suppressor genes. Therefore, this study in
Autor:
Luis M. Barrazueta, Daniel Araki Ribeiro, Nora Manoukian Forones, Thiago Simão Gomes, Helena Regina Comodo Segreto, Flávio de Oliveira Lima, Celina Tizuko Fujiyama Oshima, Henrique de Oliveira Costa
Publikováno v:
Pathology, research and practice. 207(10)
The purpose of this investigation was to analyze the immunoexpression of FasL, Fas, FADD, cleaved caspase 8, and cleaved caspase 3 in gastric cancer. Formalin-fixed and paraffin-embedded gastric adenocarcinoma tissues from 87 patients, including adja
Autor:
Ulrich R. M. Bohr, Hans Lippert, Andrew Silver, Peter Malfertheiner, Brigitte Peters, Frank Meyer, Arndt Hartmann, Regine Schneider-Stock, Thomas Guenther, Frauke Bataille, Susanne Biesold, Doerthe Kuester, Petra Ruemmele, Albert Roessner, D. Schubert
Publikováno v:
Pathology, research and practice. 206(9)
Death-associated protein kinase (DAPK) has pro-apoptotic functions and participates in various apoptotic systems. DAPK acts as a tumor suppressor, and its inactivation by promoter hypermethylation has been frequently observed in various human cancers