Zobrazeno 1 - 10
of 15
pro vyhledávání: ''
Publikováno v:
Pathology, research and practice. 227
Aims HER2 and osteopontin (OPN) are both important biomarkers in gastric cancer (GC). The relationships between them remain to be revealed. The purpose of this study is to explore the role of OPN in epithelial-mesenchymal transition (EMT) in HER2 pos
Publikováno v:
Pathology, research and practice. 216(5)
Background Autophagy, which is stimulated by cellular or environmental stresses, is involved in several distinct biological processes, and the regulation mechanism is complex. Autophagy has been reported to modulate immune system components. In the p
Autor:
Ulrike Stein, Michael Hummel, David Horst, Erika Berg, M. von Winterfeld, Beate Rau, Severin Daum, Alexander Arnold, C Treese
Publikováno v:
Pathology, research and practice. 215(11)
Small molecule inhibitors such as Larotrectinib have been recently approved in the treatment of patients with fusions of the neurotrophic-tropomyosin receptor tyrosine kinase (NTRK) genes 1-3. These genomic rearrangements have been reported across di
Publikováno v:
Pathology, research and practice. 215(6)
We previously demonstrated that the functional inactivation of DAL-1 and TOB1 promotes an aggressive phenotype in gastric cancer cells, but the links between both genes and the survival of patients with gastric cancer are unknown. Here, we investigat
Autor:
Yan Zhou, Wei Zhao, Guipeng Ding, Zhenqing Feng, Bing Wang, Qiuyan Xia, Xiaohua Li, Jin Zhu, Xudong Wang, Hongmei Yong
Publikováno v:
Pathology, research and practice. 215(5)
Epiregulin (EREG) is a novel family member of EGF-like ligands and have elevated expression in a variety of human cancers. EREG expression promotes tumor progression and metastasis and reduces patient survival. However, the expression of EREG and its
Autor:
Won Ki Kang, You Jeong Heo, Hyunsik Bae, Jongmin Sim, Binnari Kim, Kyoung-Mee Kim, Junhun Cho, Hyeong Chan Shin, Seung Tae Kim, Jeeyun Lee
Publikováno v:
Pathology, research and practice. 215(3)
Background MET is a tyrosine kinase receptor for the hepatocyte growth factor, and its overexpression is a poor prognostic factor in gastric carcinomas. Programmed death-ligand 1 (PD-L1) is an important biomarker of immunotherapy and is frequently po
Publikováno v:
Pathology, research and practice. 215(3)
Background GPR110 is a member of the adhesion G protein-coupled receptor family, which has been identified as an oncogene in various cancers, including hepatocellular carcinoma, lung cancer, prostatic cancer and glioma. Whereas the expression and the
Publikováno v:
Pathology, research and practice. 213(8)
To explore the clinicopathological significance of ATM gene in the occurrence and prognosis of gastric cancer (GC) from different nationalities in Xinjiang.The expression of ATM in 385 patients with GC (including 98 Uygurs, 231 Hans and 56 Kazaks) an
Autor:
Eun Hee Lee, Sang Bong Jung, Hyoun Wook Lee, Kyungeun Kim, Moon-il Park, Mee-Seon Kim, Mee Sook Roh, Seok-Hyun Kim
Publikováno v:
Pathology, research and practice. 211(4)
Multiple intracellular transforming signals regulate eukaryotic translation initiation factor 4E (eIF4E)-binding protein (4E-BP1). The signals result in hierarchical phosphorylation of 4E-BP1, resulting in release of eIF4E, relieving translational re
Publikováno v:
Pathology, research and practice. 209(10)
SIRT1 and p300/CBP, which are considered to be essential histone deacetylases and acetyltransferases, are also considered to be relative to tumorigenesis because they modulate the expression of several tumor suppressor genes. Therefore, this study in