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Publikováno v:
Pathology, research and practice. 223
Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity with poor prognosis. The dysregulation of Notch signaling pathway has been implicated in the OSCC tumorigenesis. However, the clinical implication of NOTCH1 mutation
Publikováno v:
Pathology, research and practice. 216(11)
Liver is a major metabolic organ containing many metabolic enzymes. Disorders of liver-specific enzymes can cause liver dysfunction and tumorigenesis. Previous studies indicated that 4-Hydroxyphenylpyruvate dioxygenase (HPD) plays an essential role i
Publikováno v:
Pathology, research and practice. 215(11)
Background Glutathione peroxidase 3 (GPX3) provides critical protection against reactive oxygen species (ROS) in cells. Downregulation of GPX3 may contribute to carcinogenesis of esophageal squamous cell carcinoma (ESCC), but the mechanisms are not c
Autor:
Kunxiang Luo, Chuanhua Zheng, Guanglong Huang, Yiliang Meng, Tianshi Que, Qianli Tang, Peng Yan, Xiaoping Chen, Haineng Huang, Juxin Gong, Hongcheng Luo, Jia Liu, Huangde Fu, Rentong Hu, Qisheng Luo
Publikováno v:
Pathology, research and practice. 216(3)
Recent researches indicated Ddx5 and Ddx17 play crucial roles in tumorigenesis. However, the study of Ddx5 and Ddx17 in glioma remains a little. Our study investigated their expression in glioma and evaluated its association with clinical factors and
Publikováno v:
Pathology, research and practice. 215(10)
The genetic alterations (GAs) in two specific histological subtypes of colorectal cancer (CRC), signet ring cell colorectal carcinoma (SRC) and mucinous colorectal carcinoma (MC), are not well known. In the present study, we employed next-generation
Publikováno v:
Pathology, research and practice. 215(1)
Liver cancer is one of the few tumors with a steadily increasing morbidity and mortality; hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. We combined the expression profiles of Chaperonin Containing T-complex 1 Subunit
Publikováno v:
Pathology, research and practice. 214(10)
Ubiquinol-cytochrome c reductase complex core protein 2 (UQCRC2) is an important subunit of mitochondrial respiratory complex III. However, its role in tumorigenesis and tumor progression remains unknown, especially with regards to colorectal cancer
Autor:
Priscilla Brebi, Juan Carlos Roa, Kurt Buchegger, Jaime Lopez, Pamela Leal, Juan Carlos Araya, Ramón Silva, Ismael Riquelme, Carmen Ili
Publikováno v:
Pathology, research and practice. 213(5)
Gallbladder cancer (GBC) is a highly fatal disease with poor prognosis and few therapeutic alternatives. Molecular profiling has revealed that the deregulation in the ERK/MAPK signaling pathway plays a crucial role in many disease and malignancies, i
Publikováno v:
Pathology, research and practice. 210(8)
Background and Aim To explore the expression and role of activating transcription factor 3 in human hepatocellular carcinoma. Methods Immunohistochemistry, Western blot assay and Real-time PCR were used to evaluate activating transcription factor 3 p
Publikováno v:
Pathology, research and practice. 209(10)
SIRT1 and p300/CBP, which are considered to be essential histone deacetylases and acetyltransferases, are also considered to be relative to tumorigenesis because they modulate the expression of several tumor suppressor genes. Therefore, this study in