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Publikováno v:
Pathobiology. 89:324-333
Immunohistochemistry techniques have been incorporated into surgical pathology for nearly a half-century and have since become intimately intertwined with its practice. In the realm of breast pathology, immunohistochemistry serves several purposes, i
Autor:
Islam M. Miligy, Michael S. Toss, Kylie L. Gorringe, Ian O. Ellis, Andrew R. Green, Emad A. Rakha
Publikováno v:
Pathobiology. 89:382-392
Introduction: Aurora Kinase A (AURKA/STK15) has a role in centrosome duplication and is a regulator of mitotic cell proliferation. It is over-expressed in breast cancer and other cancers, however; its role in ductal carcinoma in situ (DCIS) remains t
Autor:
Zaibo, Li, David J, Dabbs
Publikováno v:
Pathobiology. 89:309-323
Immunohistochemistry (IHC) plays an important role in the evaluation of breast pathology specimens to provide both diagnostic and prognostic/therapeutic information. Although most IHCs used in breast pathology can be easily interpreted, pitfalls do e
Autor:
Daniel Pinto, Fernando C. Schmitt
Publikováno v:
Pathobiology. 89:343-358
Fine-needle aspiration biopsies (FNABs) of the breast are minimally invasive procedures enabling the diagnosis of suspicious breast lesions. Unfortunately, they are often perceived as inferior to core-needle biopsies, namely because they are supposed
Autor:
Iara Viana Vidigal Santana, Rodrigo de Oliveira Cavagna, Pedro De Marchi, Leticia Ferro Leal, Flavio Augusto Ferreira da Silva, Gustavo Noriz Berardinelli, Vinicius Duval da Silva, Eduardo Caetano Albino da Silva, Rui Manuel Reis, Icaro Alves Pinto
Publikováno v:
Pathobiology. 89:101-106
Background: Microsatellite instability (MSI) in non-small cell lung cancer (NSCLC) is uncommon; however, most studies refer to European and Asian populations. There are currently no data on MSI frequency in highly admixed populations, such as the one
Publikováno v:
Pathobiology. 88:359-373
Introduction: Solid papillary carcinoma (SPC) and encapsulated papillary carcinoma (EPC) of the breast are usually considered in situ lesions due to favorable prognosis, despite the variable presence of myoepithelial cells. We aimed to describe clini
Autor:
Noely Paula Cristina Lorenzi, Lara Termini, Cristina Paula Castanheira, Rafaella Almeida Lima Nunes, Mayara Luciana Sallas
Publikováno v:
Pathobiology. 88:187-197
Persistent infection with some types of mucosal human papillomavirus (HPV) is the etiological factor for the development of cervical cancer and its precursor lesions. Besides, several cofactors are known to play a role in cervical disease onset and p
Autor:
Mieke R. Van Bockstal, Pamela Baldin, Jessica Vanhaebost, Yves Horsmans, Gregory Schmit, Julie Lelotte
Publikováno v:
Pathobiology, Vol. 88, no. 1, p. 88-94 (2021)
Pathobiology
Pathobiology
Introduction: The coronavirus disease 2019 (COVID-19) infection, caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), involves several organs through participation of angiotensin-conversion enzyme 2 (ACE2) receptors. The presence
Autor:
Salome Waldvogel, Elisabeth Bruder, Sven M. Schulzke, Han Chen, Cécile Monod, Sizun Jiang, Thomas Menter, Irene Hösli, Alexandar Tzankov, Kirsten D. Mertz
Publikováno v:
Pathobiology
Since the outbreak of coronavirus disease 2019 (COVID-19), there has been a debate whether pregnant women are at a specific risk for COVID-19 and whether it might be vertically transmittable through the placenta. We present a series of five placentas
Autor:
Kazuaki Tanabe, Naohiro Uraoka, Hideki Ohdan, Naoya Sakamoto, Narutaka Katsuya, Yuji Yamamoto, Ryuichi Asai, Naohide Oue, Wataru Yasui, Kazuhiro Sentani
Publikováno v:
Pathobiology. 87:254-261
Objectives: Esophageal cancer is the sixth most common malignancy worldwide. Signal peptidase complex 18 (SPC18) protein, which is encoded by the SEC11A gene, is one of the subunits of the signal peptidase complex and plays an important role in the s