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Autor:
Lars Viktrup, David Li, Alan J. Kivitz, Timothy E. McAlindon, Seiji Ohtori, John D. Markman, Manuel Pombo-Suarez, Candace Bramson, Robert Bolash, Frank W. Roemer, Kenneth M. Verburg, Christine R. West
Publikováno v:
Pain
Supplemental Digital Content is Available in the Text. Placebo and tramadol-controlled study assessing long-term safety and efficacy of tanezumab in patients with chronic low back pain and inadequate response to standard analgesics.
This randomi
This randomi
Autor:
Ian E. James, David G. Soergel, Franck Skobieranda, Brian M. Sadler, Jonathan D. Violin, Lynn R. Webster, Nancy Burnham, Ruth Ann Subach, Michael W. Lark
Publikováno v:
Pain. 155:1829-1835
Opioids provide powerful analgesia but also efficacy-limiting adverse effects, including severe nausea, vomiting, and respiratory depression, by activating μ-opioid receptors. Preclinical models suggest that differential activation of signaling path
Autor:
Lynn R. Webster, Eugene R. Viscusi, Seth Zuckerman, James A. Bolognese, David G. Soergel, Emily Cook, Franck Skobieranda, Michael E. Kuss, Ruth Ann Subach, Stephen E. Daniels
Publikováno v:
Pain. 157(1)
Efficacy of conventional opioids can be limited by adverse events (AEs). TRV130 is a structurally novel biased ligand of the μ-opioid receptor that activates G protein signaling with little β-arrestin recruitment. In this phase 2, randomized, place
Publikováno v:
Pain. 136:232-234
The results of two 6-months long, randomized, double-blind, controlled trials (RCT) of the anticonvulsant pregabalin (Crofford et al., 2008) and the balanced serotonin-norepinephrine re-uptake inhibitor (SNRI) duloxetine (Russell et al., 2008) are pu
Publikováno v:
Pain. 66:247-251
Objectives: To compare the relative merits of single doses of ibuprofen and ibuprofen plus caffeine in the treatment of pain after third molar removal. Design: Randomised, double-blind, placebo-controlled, single-dose parallel-group comparison of pla
Publikováno v:
Pain. 65:45-51
The efficacy of topical aspirin/diethyl ether (ADE) mixture in the treatment of acute herpetic neuralgia and postherpetic neuralgia, suggested in a previous open-label study (De Benedittis et al. 1992), has been evaluated in a double-blind crossover
Publikováno v:
Pain. 48:383-390
Topical aspirin/diethyl ether (ADE) mixture was used to treat 45 consecutive patients with acute herpetic neuralgia (AHN) ( n = 28) and with post-herpetic neuralgia (PHN) ( n = 17) in an open-label study. Good-to-excellent results were achieved by 93
Publikováno v:
Pain. 48:83-88
Although the analgesic effects observed during the application of vibration may be attributable to neuronal inhibition of the pain pathways, this does not account for the fact that pain relief sometimes persists for a long time after the end of vibra
Publikováno v:
Pain. 44(2)
Caffeine is frequently added to mild analgesic preparations but its effect when used alone on pain has never been studied in humans. Using a double-blind placebo-controlled multiple crossover design, 53 patients with non-migrainous headaches were giv
Publikováno v:
Pain. 32:159-163
Orally administered ethyl alcohol (1 ml/kg of 100% ethyl alcohol + 1 ml/kg tonic water) (the equivalent of two cocktails) produced tolerance to experimentally induced pain comparable to 0.17 mg/kg s.q. morphine (11.6 mg in a 70 kg person) [corrected]