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Publikováno v:
Oxidative Medicine and Cellular Longevity. 2022:1-25
The liver is the largest digestive organ in the human body. The increasing incidence of chronic liver fibrosis is one of the major health challenges in the world. Liver fibrosis is a wound-healing response to acute or chronic cellular damage of liver
Autor:
Linbin Zhou, Jing Na He, Lin Du, Bo Man Ho, Danny Siu-Chun Ng, Poemen P. Chan, Clement C. Tham, Chi Pui Pang, Wai Kit Chu
Publikováno v:
Oxidative Medicine and Cellular Longevity. 2022:1-9
Primary open-angle glaucoma (POAG) is the most common form of glaucoma, for which elevated intraocular pressure (IOP) is a major risk factor. IOP is mainly regulated by dynamic balance of aqueous humor (AH) production and outflow via the conventional
Publikováno v:
Oxidative Medicine and Cellular Longevity. 2022:1-14
The prodrug–enzyme regimen ZD2767P+CPG2 is limited by low efficacy. Here, ultrasound was used to modulate ZD2767P+CPG2 (i.e., ZD2767P+CPG2+US) against cisplatin-resistant human lung cancer cells. A549 and A549/DDP (resistant subline) cells received
Publikováno v:
Oxidative Medicine and Cellular Longevity, 2022:1070968. Hindawi Limited
Ovarian aging is associated with a decrease in fecundity. Increased oxidative stress of granulosa cells (GCs) is an important contributor. We thus asked whether there is an oxidative stress-related gene signature in GCs associated with ovarian aging.
Autor:
Haichao Yu, Zhen Zhang, Fahong Wei, Guowei Hou, Yonggang You, Xiangyu Wang, Shiqi Cao, Xiaoqing Yang, Weibo Liu, Shaofu Zhang, Fanqi Hu, Xuesong Zhang
Publikováno v:
Oxidative Medicine and Cellular Longevity. 2022:1-21
Low back pain (LBP) seriously affects human quality of life. Intervertebral disc degeneration (IVDD) is the main pathological factor that leads to LBP, but the pathological mechanism underlying IVDD has not been fully elucidated. Neuropathic pain cau
Autor:
Yuanyuan Ren, Zhuozhuo Li, Wenqing Li, Xiaobin Fan, Feifei Han, Yaoyao Huang, Yi Yu, Lu Qian, Yuyan Xiong
Publikováno v:
Oxidative Medicine and Cellular Longevity. 2022:1-20
Arginase is a ubiquitous enzyme in the urea cycle (UC) that hydrolyzes L-arginine to urea and L-ornithine. Two mammalian arginase isoforms, arginase1 (ARG1) and arginase2 (ARG2), play a vital role in the regulation of β-cell functions, insulin resis
Autor:
Nirupama Kandula, Saurabh Kumar, Venkata Kiran Kumar Mandlem, Aneela Siddabathuni, Sanjay Singh, Ramoji Kosuru
Publikováno v:
Oxidative Medicine and Cellular Longevity. 2022:1-18
Recent studies indicate cell death is the hallmark of cardiac pathology in myocardial infarction and diabetes. The AMP-activated protein kinase (AMPK) signalling pathway is considered a putative salvaging phenomenon, plays a decisive role in almost a
Publikováno v:
Oxidative Medicine and Cellular Longevity. 2022:1-14
Objective. This study further explored LINC00958’s role in promoting tumor angiogenesis (AG) and oxidative stress (OS) development by inhibiting BC cell autophagy through sponge adsorption of miR-625-5p. Methods. BC patients and healthy controls wh
Publikováno v:
Oxidative Medicine and Cellular Longevity. 2022:1-19
Background. Some recent studies have reported the role of circular RNAs (circRNAs) in modulating the tumorigenesis of human malignancies. Nevertheless, the expression characteristics, biological functions, and regulatory mechanism of circ_0000189 in
Publikováno v:
Oxidative Medicine and Cellular Longevity. 2022:1-20
Anthocyanins are known for their therapeutic efficacy for many human diseases, including cancer. After ingestion, anthocyanins degrade due to oxidation and enzymatic breakdown, resulting in reduced therapeutic efficacy. Direct delivery to target tiss